Tag: "antigen" at biology news

New mouse model shows how news of pathogen reaches immune system

...ria in its bowels, loading the resulting pieces of antigen onto antigen-carrying molecules known as major his...cell supposedly arrived in the lymph node with the antigen complex in full view, like a peacock with all its feathers on display, an act referred to as antigen...

Transplant patients from 40 years ago cause Pittsburgh doctors to take an about-face

...important to weaken the T cell response before the antigen the donor organ is introduced, he explained. In more than 250 recipients of liver, kidney, kidney/pancreas, intestine and multivisceral transplants, the University of Pittsburgh team administered a single dose of rabbit anti-thymocyte globulin, whi...

Discovery sheds light on how breast cancer cells progress to more aggressive forms

.... The new protein, termed MTA1s (metastatic tumor antigen 1, short version), appears to intercept the key protein receptor that is responsible for communicating with the female hormone estrogen inside cells. An estimated 192,200 women will be diagnosed with invasive breast cancer and 40,200 women will die...

New gene may be breast-specific cancer markers

... physician to perform a test for prostate-specific antigen (PSA) to detect the presence of prostate cancer. And according to a recent report from Irish researchers, women may one day be able to order an equivalent of this simple test to identify the presence of breast cancer. The study, "Mammaglobin A: A P...

Ulcer-causing bacteria use stomach inflammation to their advantage

...ed that H. pylori used a molecule known as Lewis B antigen (Leb) to adhere to stomach cells, findings that al...t protein used by the bacterim, calling it Lewis B antigen binding adhesin (BabA). That discovery also appeared in Science. The present study began with the i...

UCLA scientists develop prostate cancer tracking system

...ostate cancer cells based on the prostate-specific antigen (PSA) protein expressed only in prostate cells. Using the substance that makes fireflies glow, scientists showed through high-tech imaging that the prostate-targeted virus made prostate cancer cells appear as "hot spots," both in primary tumors and i...

Other highlights in the July 17 issue of JNCI

...ese measurements with a standard prostate-specific antigen (PSA) test increased the specificity (correct identification of patients without prostate cancer) but decreased the sensitivity for detecting patients with prostate cancer compared with a PSA test alone. The authors conclude that levels of IGF-I and ...

Making the most of lymphopenia

...r. After recognizing the antigens presented by the antigen presenting cells, the immune cells become activate...ues found was that if these T cells see the cancer antigen when they proliferate, they will have a marked bias towards the cancer antigen, seek out cancer cell...

Clemson researchers create biosensors to protect nation's food and water supplies

...mall size increases the odds that the antibody and antigen will link, enabling the sensor to give off a glow. The more connections, the greater the glow." Derived from the Greek word for midget, "nano" means a billionth part. A nanometer (abbreviated nm), for example, is one billionth of a meter. An atom me...

Cell Genesys reports long term survival data in Phase II trial of GVAX prostate cancer vaccine

... measured by both radiologic and prostate-specific antigen (PSA) endpoints also in favor of the high dose group. Treatment with GVAX vaccine was safe and well tolerated. These data were presented at the American Society of Clinical Oncology (ASCO) Meeting in Orlando, FL by Jonathan Simons, M.D., of Emory U...

Promoting wound repair

...ithelial cell common in the epidermis, release the antigen that is recognized by the gamma-delta T cells, which then become activated. Once activated, the gamma-delta T cells begin making a growth factor that binds to keratinocytes and other epithelial cells, helping them proliferate and leading to the closu...

Brain cancer vaccine shows promising findings in early research at UCLAs Jonsson Cancer Center

...e attack. To make the vaccine, researchers used an antigen known to be recognized by the immune system. The antigen was partnered with a common form of bacteria, called Listeria monocytogenes, which UCLA scientist Je...

Stanford's new antigen microarrays open window to better disease screening

...t options. "Right now clinicians test each antigen separately - and each one can take weeks," said P....agnose the disease on the first visit." The antigen microarrays - developed in collaboration with Lawrence Steinman, MD, professor of neurology and neur...

Anti-malarial assistant

... an effective adaptive immune response, a specific antigen is injected along with an adjuvant (traditionally a crude extract that promotes an immune response). Although protective antigens have been defined, a problem in formulating an effective malarial vaccine is that it is difficult to get the immune sys...

Tips from the Journals of the American Society for Microbiology: February 2002

...uman use are based on a protein, called protective antigen (PA), that is secreted by the anthrax bacteria. This protein is a required component of anthrax toxins and vaccines based on PA teach the body to recognize and neutralize the anthrax toxins, preventing the toxic effects of infection, but not prevent...

Viral protein may be associated with human brain tumors

...ational Cancer Institute . Both agnoprotein and T antigen are protein products of the JC virus (JCV), a huma...ld's developing brain through infected B cells. T antigen may cause brain tumors in part by blocking tumor suppressor proteins such as p53 and pRb. The role o...

Viral proteins may be associated with human brain tumors, according to findings by Temple researchers

...gators found the viral genome and viral proteins T antigen and agnoprotein in samples of pediatric brain tumo... and an agnoprotein, whose function is unknown. T antigen may cause brain tumors in part by blocking tumor suppressor proteins such as p53 and pRb. The role o...

Third piece completes deadly puzzle: Structure of anthrax toxin offers clues to treatment

...k, leading to death. The structure for protective antigen was published in February, 1997, and that of lethal factor in November, 2001. The structure of the third toxin, called edema factor because it causes fluid accumulation, provides the last piece of this pathogenic puzzle. Tang, his graduate stude...

UT Southwestern researchers develop new method of delivering vaccines

...riment, a polymer rod releasing a tumor-associated antigen was then implanted under the skin. We thought thes... Langerhans cells would carry the tumor-associated antigen to the draining lymph nodes and initiate protective immunity against tumor development. Our subsequ...

Testosterone dose-repsonse relationships in healthy young men

...s, blood counts and chemistries, prostate-specific antigen (PSA), plasma lipids, total and free testosterone, luteinizing hormone (LH), sex steroid-binding globulin (SHBG), and insulin-like growth factor I (IGF-I) levels were measured periodically during control and treatment periods. Serum total testosteron...

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