Israeli scientists block the progression of Type I diabetes
...esponding to an antigen. It can act to destroy the antigen or alternatively protect it from destruction. In this case it indirectly prevents the pancreatic cells from being destroyed. The scientists participating in this study are: Professor Itamar Raz and Dr. Muriel Metzger from Hadassah-Hebrew University ...University of Pittsburgh researchers define precursors to cells that control the immune response
...ting cells, meaning that when the LCs encounter an antigen in the presence of a "danger signal" like a pathog...he skin to the lymph nodes, presenting a processed antigen to T-cells, initiating antigen-specific T-cell immunity. "Scientists have known that LC precursors e...Cyclin B1 identified as a new tumor antigen and candidate for the development of a cancer vaccine
... the protein cyclin B1 is a newly identified tumor antigen that holds promise as a candidate for the development of a cancer vaccine. The new antigen will be used in future cancer vaccine trials for breast cancer, lung cancer and head and neck cancer...USF Alzheimer's vaccine research boosted by $1.1-million NIH grant
...he anti-Alzheimer's vaccine, which contains as its antigen a synthetic version of beta amyloid, the protein that builds up in the brains of Alzheimer's patients. Then, they will analyze the responses of immune cells to the vaccine. They will look for harmful side effects and, in particular, study the role of...Researchers announce anthrax breakthrough
...avoc inside cells. The third component, protective antigen (PA), binds to ATR and acts like a doorway for EF and LF to enter the cell. In earlier studies, Kenneth Bradley, Young's graduate student, mutated cells to find those that were resistant to infection caused by retroviruses, the family of viruses th...Researchers discover secrets of Anthrax's killer toxin
... them from working. A third component, protective antigen (PA), carries EF and LF into the cells. In the new reports, the researchers asked two critical questions: What molecule on the surface of animal cells does PA use as a doorway, or receptor, for entry; and how does the LF toxin attach to and destroy ...New DNA-base vaccine approach protects mice against anthrax
...ree gene products - protective antigen (PA), lethal factor (LF) and edema factor (EF). The protective antigen combines with the lethal factor to form a molecule known as lethal toxin, which ......of Sciences, describing why and how the binding of antigen and antibody or two complementary strands of DNA alters the surface stress and bends the cantilever. The current paper shows that cantilever deflection accurately reflects the amount of protein binding. Majumdar said that, in practice, three or four ...DNA vaccination places tumors in double jeopardy
... factor vasostatin. In addition, when expressed in antigen presenting cells, calreticulin interacts with the ...fect, suggesting that calreticulin-mediated immune antigen presentation is crucial. Mice that are treated with calreticulin DNA but that lack CD8 T cells are s...Immune co-stimulation and the Kaposis virus
...st defenses against the virus, because they act as antigen presenting cells (APCs) to activate CTL responses against infected cells. As is generally seen in APC-T cell interactions, efficient activation of CTLs against KSHV requires not just that the B cells present a viral peptide in an appropriate MHC con......ling out signals that serve to present the foreign antigen to other immune system cells that do their part to destroy it. Despite its discovery more than 100 years ago, little is known about how aspirin actually works to control pain and inflammation, or how it is beneficial for patients with autoimmune di...Georgetown researchers achieve increased cancer patient survival
... virus-based vaccines that target carcinoembryonic antigen (CEA), a protein found on the surface of colorectal, pancreatic, breast and lung cancer cells. Used in a prime-boost treatment protocol, the two products are designed to generate and sustain a therapeutic level of cytotoxic T cell activity critical ...... Campath appears to work by targeting the CD52+ antigen on the malignant lymphocytes. Campath binds to CD52+, an antigen that is present on the surface of certain leukemic lymphocytes, and induces antibody-dependent lysis...Potential new anthrax therapy discovered
...hrax therapy because the normal form of protective antigen in and of itself is already known to be safe in hu...otective antigen. In the future, mutant protective antigen may fill the bill as both an anthrax vaccine and treatment, negating the need for two separate pharm......ter lung cancer. This is the first prostate cancer antigen found. "The hope is twofold," Allison said. "One, ...blems. Allison and his colleagues found the cancer antigen by looking in a strain of mice prone to prostate cancer. They treated the mice with a therapy they d...Human trials of new vaccine technique prove promising for allergy sufferers
... attacks. Some of these vaccines, however, contain antigen so strong that, even in smaller doses, they cause an allergic reaction that can be severe and even life threatening. To create their more tolerable vaccine, the researchers discovered how to mask the reactive sites on the allergen molecule by......LIN is a monoclonal antibody that targets the CD20 antigen and is stably linked to the radioisotope yttrium-90. This investigational agent is in late stages of development for the treatment of certain NHLs. On Nov. 1, 2000, IDEC submitted a Biologics License Application (BLA) to the U.S. Food and Drug Admini...Diagnosis on a chip - molecular profiling that could improve diagnosis and help design better drugs
...c device to print hundreds of specific antibody or antigen solutions in an array on the surface of a microscope slide. Two complex protein samples are then labelled using spectrally-resolvable fluorescent dyes and applied to the slide. As the antibodies and antigens begin to interact with each other, the t...Dendreon identifies novel approach to improve immunization efficiency
...sponse could be greatly enhanced by engineering an antigen in a way that optimizes its uptake and processing ...lyzed the T-cell response elicited by the modified antigen in mouse models and found that mice immunized with the modified antigen generated significant cytoto......r of nearly 220 genes known as the human leukocyte antigen (HLA) gene complex holds clues to many unsolved medical questions: why do transplants sometimes fail despite close donor-recipient matches? What makes certain people more susceptible to specific diseases? Why do vaccines protect some individuals be...