DNA-based flu vaccine raises protective immunity
...at combining two or three copies of C3d to a model antigen increased the efficacy of immunizations by more th...esponse is mounted both in recognition of HA as an antigen and by the stimulatory effects of C3d." DNA vaccines have several distinct advantages over conventio...Even the Immune System works with Pincers
... These arms are called Fab fragments (Fab=fragment antigen binding). Via Fc receptors (Fc=Fragment crystalline), which recognize a distinct structure in the "stem" region of the Y-shaped structure (Fc fragment), immune cells (leukocytes and lymphocytes) are bound. Only now the pathogen is removed ...Life and death struggle: Proteins play against each other, bringing balance to immune system
...t then turn into "memory" T cells. If and when the antigen invades the immune system a second time, these "me... recognize the invader and bind to it, killing the antigen more quickly than during the first exposure. "You get a nuclear holocaust, not just gunfire," said D...Exisulind (Aptosyn™) and other SAANDs compounds halt prostate cancer cell growth by two mechanisms
...ular expression and secretion of prostate specific antigen (PSA) at the same concentrations that induced apoptosis in the cells. Dr. Bernard Weinstein, the senior investigator of these studies and director of the Columbia University Comprehensive Cancer Center, emphasized that "because of their dual m...Researchers successfully immunize mice against aggressive cancer
...dicate that in cases where tumors have a clear-cut antigen associated with it, we would immunize people for cancer the way we immunize them to protect against things like polio," he said. And nothing would please doctors that treat melanoma more than the development of a method of keeping people from coming ...Prostate cancer test works as well for black men, study shows
...ent nationwide trial of the free prostate specific antigen test (fPSA) a variation on the traditional PSA test shows the new test proves as accurate in revealing cancer risk in African American men as it is in Caucasians. "It also shows that many African-American men could be spared the expense and trauma o...Scientists discover key molecule in transmission of AIDS virus
...mune system and the ones targeted by HIV. Once the antigen is presented, T-cells go into action, marshalling recruits to battle a foreign foe with special messenger molecules called cytokines and chemokines. Previously, Dr. Littman and colleagues discovered that HIV must bind to chemokine receptors on the su...Proteins that bind to sperm offer clues to male fertility and possible male contraception
...ically, they might offer the source of a potential antigen (protein target) for a contraceptive vaccine. More effective methods of contraception are urgently needed to prevent the enormous overgrowth of the world's population that is expected to occur over the next half century....PSA level predicts future prostate growth
...y 11, 2000 -- The higher a man's prostate specific antigen (PSA) level is, the more likely his prostate will continue to grow abnormally, researchers at UT Southwestern Medical Center at Dallas report. Dr. Claus Roehrborn and colleagues said in January's Journal of Urology that men with a PSA level of 3.3 ...High fibre diet lowers risk of prostate cancer: study
... four months had lower levels of prostate specific antigen (PSA) -- an indicator of prostate cancerrisk -- in their blood than men on high insoluble fibre diets. Insoluble fibre is contained in foods such as wheat brancereal and breads. "Prostate cancer is a hormone-dependent cancer, which means it may be mo...Abgenix to become sole owner of Xenomouse fully human antibody technology
...ns to license the technology for a small number of antigen targets each year. Abgenix also will provide JT w...T also retains options to, or licenses on, several antigen targets it has previously nominated under the Xenotech structure. For all antibody products generat...Big brother has a lot to answer for
...Y chromosome, which is unique to males, produce an antigen called HY, and this may set off the mother's alarm bells. Each successive male would boost that response. This theory is backed indirectly by other studies. One showed that the placenta, which protects a fetus from the mother's immune system, increas...UroGenesys researchers discover new target antigen for prostate cancers
...y of Sciences (PNAS), describe anovel cell-surface antigen called STEAP which is expressed at high levels on ...cer at UroGenesys and anauthor on the paper. "The antigen is expressed at high levels on prostate tumors throughout allstages of the disease, including metast......fully human monoclonal antibodies toan undisclosed antigen in the field of autoimmune diseases. In return, Abgenix will receive atechnology access payment and could receive additional fees and milestone payments plus royalties onfuture product sales by Chiron. Under a separate research collaboration agreemen...U-M scientist discover how viruses hide inside human cells
...ed a protein called the latency-associated nuclear antigen or LANA, which is expressed by one of approximately 80 genes encoded by the virus. They found that LANA binds to three regions of the KSHV genome, but is most likely to lock onto one specific region for tethering the virus to host chromosomes. In ad...Jellyfish protein illuminates active immune cells
...my on their outer surface. When an APC displaying antigen meets a T cell bearing the appropriate antigenreceptor, the two stick together. This meeting alters gene expression in bothcells and triggers an immune response. Monks wanted to know how the signal travels from a receptor on the T cellsurface to th...New microscopy method reveals molecular map of biological surfaces
...right antibody and you can find all the places its antigen is. The moreantibodies you scan with, the more detailed the map will be. "It's exciting because we've been able to see these molecules for awhile, and now we'll be able to tell exactly what they are." Lindsay points out that the techn...Rockefeller researchers inject cells, boost immune system in humans
...d sometimes the patients received soluble doses of antigen as well.This made it hard to be certain an immune ...s that had been exposed to three differentkinds of antigen -- one associated with tetanus, one from influenza and one derivedfrom a mollusc that humans would n......e was known about how T cells decide whether a new antigen ispresent or not. This decision requires a period ...ity School of Medicine anddiscoverer of the T cell antigen receptor. A key part of the method was theability to reconstitute the function of an antigen-present......show that the mucosal immune response tothe target antigen can be induced by an intranasal immunization with anadenoviral recombinant. Dr. Wlazlo is simultaneously studying oncoproteins expressed by HPV strains 16and 18, which are known to cause cancerous transformations in the cells. Dr.Wlazlo is exploring...