Pitt Researchers Develop Strategy To Use Dendritic Cells To Treat And Prevent Tumors
...ers a single solution to both the problem of tumor antigen identification andantigen delivery. "By using tumor cells as a source of antigen, this approach eliminatesthe need to identify and purify tumor antigens," added Dr. Falo. The approachrelies on the ability of DC's to "present" antigens they o...RNA-Dendritic Cell Combo Shows Promise As A Universal Cancer Vaccine
...RNA from a patient, we do notneed to determine the antigen it expresses, or a patient's immune fingerprint,an...m on their own cell surface. This show of aforeign antigen signals a strong response from immune system fighters known as"killer T" cells which move out from t...Insights Into The Proteasome - A Fascinating Macromolecular Machine For Protein Degradation
...esumed to be related to the proteasomes role in antigen processing. Recently, Christopher Hill and coworkers from the university of Utah, Salt Lake City, have solved the crystal structure of the heptameric complex, which is traversed by a funnel-shaped channel, the wider opening oriented to th...Study Shows: Just Say NO To Bone Loss
... helpsdegrade bone. Previous analysis of the novel antigen indicated that it functions on theosteoclast cell ...process. Osdoby and hiscolleagues believe if this antigen protection is lost, the osteoclast will stopresorbing by a process that uses NO as a feedback signal...Biotech Approach To Feral Cat Problem Devised
...mmune system, the Salmonella are killed and the ZP antigen is released and stimulates production of antibodies against ZP. Because these antibodies bind to the ZP surrounding the egg, they inhibit the binding of sperm and thus block fertilization. Scientists have looked at various techniques for delivering...Gene Therapy Enables Transplantation Without Immunosuppressive Drugs
...l thatalerts the cell to the presence of a foreign antigen occurs at the site of amolecule called the major h...imulatory signal is blocked at the time of foreign antigen presentation --at the time of surgery and in the period immediately thereafter, in this case --then ...Hurdle In Ulcer Vaccine Development Cleared
... called the Lewis b (Leb) blood groupantigen. This antigen is found on the red blood cells of people with typ...ed on the surface of H. pylori-- BabA (blood group antigen binding adhesin) -- attaches to the Leb antigen.They also found that H. pylori strains from diffe...Herpes Virus Strain Identified As A Trigger In Multiple Sclerosis
...ent had an increase in immune response to an early antigen of HHV-6,compared to only 18 percent of those participants who served as normalvolunteers. In addition, the scientists detected HHV-6 DNA in the serum (amarker of active virus infection) of 15 of 50 individuals with MS. All 47individuals without MS ......ch has focused solely onhow these proteins, called antigen 85, help defend the body against TB. Antigen85 act...ated with this enzymatic activity that we realized antigen 85 has two verydifferent roles." In the study, Belisle and his colleagues confirmed that ant...New Vaccine Blocks Viral Entry In Cattle, May Have Implications For Human Vaccines
... get a much different response by placing the same antigen on mucosa. That response stimulates a completely different part of the immune system, which appears to protect the body's surfaces. Our idea was to stimulate that part of the immune system." Letchworth and research assistant Xiaoping Zhu tested the...Prostate Cancer's Aggressiveness May Be Predicted Early By The Ratio Of Free To Total PSA
The ratio of free to total prostate specific antigen (PSA) in a man's blood may predict at the time of diagnosis whether prostate cancer will be an aggressive, fast-growing disease or a non-aggressive, slow-growing type of cancer. This discovery by researchers at the National Institute on Aging (NIA) a...Laser Microscope At Cornell Images Serotonin In Live Cells
...se," she said. The researchers used a pollen-like antigen to add to the solution that turned the signal on in the cell. As that was happening, the laser was illuminating the process to visualize the granules. Webb said he hopes to use the technology to look for serotonin secretions deep inside the brain. ...Prostate Cancer May Be Predicted 10 Years Before Diagnosis
...es of the ratio of free to total prostate specific antigen (PSA) in a man's blood can predict a diagnosis of prostate cancer up to six years earlier than current prediction methods. This discovery by researchers at the National Institute on Aging (NIA) and colleagues at the Johns Hopkins University School o...Mechanism For Disease Resistance Identified In Plants
...rganism. The avirulence protein acts much like an antigen in animals, eliciting an immune response from the plant. Researchers suspect that the resistance mechanism observed in tomatoes also occurs in many other plants. Their results appear in the December 20 issue of the journal Science . Having......rganism. The avirulence protein acts much like an antigen in animals, eliciting an immune response from the plant. Researchers suspect that the resistance mechanism observed in tomatoes also occurs in many other plants. Their results appear in the December 20 issue of the journal Science . Havi...