Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
...he immune system and at the same time sneak cancer antigens into cells to optimally stimulate a potent "acquir...s or cancer cells. One of the problems with cancer antigens is that that cancer cells look like the body's own cells, and so the immune system doesn't attack th...Cell's gatekeeper for ammonia revealed in unprecedented detail
...he Rh factors, most familiar as the Rh blood group antigens on the surface of red blood cells that can cause t... antigenic incompatibility of mother and child. Rh antigens have only recently been found to be transmembrane channels that regulate the movement of ammonia and...JCI table of contents: 1 September, 2004
...ifically express immune-reactive substrates called antigens in either the liver cells or the hepatic lymph nod... by the development of hepatitis. If, however, the antigens were in the liver cells, and immune cell activation occurred within the liver tissue, the immune res...Researchers uncover secrets of immune system's munitions factory
...tibodies that will recognize billions of different antigens the fragments of foreign invaders that are used to call the immune system to arms. The presence of an antigen on the surface of a B cell stimulates it to produce antibodies. An important step in this process is the activation of AID, which causes la...UC Irvine scientists to develop vaccine to combat bioterrorism threat from deadly bacteria
...ded by the genes in B. pseudomallei , to identify antigens useful for developing a vaccine against the bacterium. UCI's Center for Virus Research is in the School of Biological Sciences. Felgner will be joined in the research at UCI by Luis Villarreal, director of the center, and D. Huw Davies, an immunolog...Regular physical activity really does boost immune system in older men
...cally utilized in vitro tests or vaccine or recall antigens to elicit an immune response. In the first stage, all subjects were "immunized" with KLH with blood collected on day one and then each week for a month. The samples were comprehensively tested by ELISA (enzyme-linked immunoabsorbent assay) for anti-K...Researchers find clues about how antibodies specialize
...system's ability to defend against a vast array of antigens through genetic rearrangements, as well as the mechanisms the body uses to suppress genomic instability, an increased tendency toward gene mutation that can lead to cancer. In recent years, these two lines of investigation--immunology and cancer -- ...Nucleic acid-amplification testing further safeguards nation's blood supply
...been missed by tests to detect viral antibodies or antigens (proteins from the virus), the types of screening ...or to develop an immune response, and detection of antigens requires time for a higher level of virus to appear in the bloodstream. With the use of NAT for HC...JCI table of contents, 16 August, 2004
...go on to develop additional autoantibodies against antigens from pancreas islet cells and, from there, progress to type 1 diabetes mellitus (T1DM). In a standard immune response, antibody maturation through repeated exposure to antigen results in increased antibody affinity. Ezio Bonifacio and colleagues, fro...Evolvability could be a driving force in drug resistance
...argue that wide variation among bacteria and other antigens has put selective pressure on our immune systems to rapidly adapt methods of identifying and attacking invaders. Similar observations on the rapid mutability among flu viruses and other invading pathogens provide additional evidence, they said. "The ...Preschool bolsters early childhood immunity, reduces risk of young adult Hodgkin's lymphoma
...so in response to exposure to such Th1-stimulatory antigens as intracellular bacteria and viruses. These incl...ldren who are sheltered from contact with Th1-type antigens continue to be biased toward Th2 immunity, which promotes the development of asthma and other atopic...Patients' cells from tumors, the immune system merged for customized cancer therapy
... cells with their complete array of tumor-specific antigens and combine them with the potent immune stimulatin...molecules, but most tumors don't have well-defined antigens that can be isolated or have proved useful for vaccination development. Previous research approaches...Tips from the journals of the American Society for Microbiology
... in the mouse," say the researchers. "Thus, these antigens are promising candidates for an effective and safe vaccine against strangles."(M. Flock, K. Jacobsson, L. Frykberg, T.R. Hirst, A. Franklin, B. Guss, J.I. Flock. 2004. Recombinant Streptococcus equi proteins protect mice in challenge experiments an...Scientists receive awards, give lectures at the ASBMB/IUBMB meeting
...and class II human major histocompatiblity complex antigens and their recognition of self and foreign peptides for presentation to the immune system....Lab mice rescued from Type 1 diabetes via dendritic cell-assisted therapy
...ease develops when normal body cell markers called antigens are not recognized by the immune system as part of the body, or self. Instead, the immune system acts as if the body's own cells are foreign pathogens. The immune system's inflammatory response slowly destroys the islet cells responsible for producin...Late invasion of infected cells into the brain causes HIV dementia say Temple researchers
...that travel throughout the body and ingest foreign antigens to protect against infection--into the brain, according to researchers at Temple University's Center for Neurovirology and Cancer Biology ( http://www.temple.edu/cnvcb/ ), debunking a longstanding "Trojan Horse" theory that early infection by macroph...Temple virologist receives NIH grant to continue investigation of HIV dementia complex
...that travel throughout the body and ingest foreign antigens to protect against infection--in the development of HIV dementia complex. "Basically, HIV infection of the central nervous system and the brain is really the cause of severe HIV dementia, and currently 10 percent of AIDS patients get this type of de...Other Highlights in the June 2 JNCI
...creening for an immune response to cancer-specific antigens by using protein microarrays could lead to improved biomarkers of disease." Contact: Sally Pobojewski, Senior Science Writer, University of Michigan Medical School, 734-764-2220, pobo@umich.edu More Effective Method of PLK1 Gene Silencing Inhibit...Functional genomics enables easy target identification and drives drug discovery
...ities of identifying more than 10,000 novel target antigens in the human genome may accelerate the discovery of new drugs and therapeutic molecules. "As opposed to conventional sequence homology, functional genomics adds structure-based predictions to locate gene sequences with assigned and confirmed function......ntestinal mucosa is challenged with more bacterial antigens than any other tissue in the body. Previous work h...l microbiota. However, identification of microbial antigens underlying such intestinal disorders remains difficult due to the diversity of microflora present in...