Phase II trials of second-generation antisense cancer drug planned following successful early study
...nd: Phase II trials of the first second-generation antisense cancer drug to be used in patients are soon to be ...specifically targeted gene. As a second-generation antisense drug, OGX-011 is an advance on earlier ones in that the molecules have a longer tissue half life and...16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
...ts of Phase I trial of the first second generation antisense cancer drug - phase II getting under way * Dr Grant McArthur: Award winning researcher reveals potential new role for Glivec in a soft tissue cancer Chairman: Professor Jaap Verweij (EORTC chairman of conference scientific committee) together with s...Final Alert: 16th EORTC NCI AACR Symposium
...ults from Phase I study of first second-generation antisense cancer drug used in patients Trial shows which brain cancer patients benefit from temozolomide genetic predictive test clears way to targeted treatment New study indicates arsenic could be suitable first-line treatment for a type of leukaemia Pr...Trojan Horses, xenon imaging and remote controlled genes
... caging molecules xenon, gene-blocking strands of antisense DNA and even therapeutics to facilitate their ent... light to turn genes off. They have created caged antisense molecules stretches of DNA that can clamp on top of working genes that are released when their che...Brain's reward circuitry revealed in procrastinating primates
...riginally used in mice. He fashioned an agent (DNA antisense expression construct) that, when injected directly into the rhinal cortex of four trained monkeys, spawned a kind of decoy molecule which tricked cells there into turning-off D2 expression for several weeks. This depleted the area of D2 receptors, im...Other highlights in the August 4 JNCI
...taly, and colleagues show that by encapsulating an antisense oligonucleotide targeting an oncogene and activating the innate immune system in a liposome that specifically targets neuroblastoma cells, neuroblastoma-bearing mice lived longer than mice given any other treatment in the study. Contact: Mirco Ponzon...New genetic mechanism for evolution
...nes adjacent to them by inducing a molecule called antisense RNA. This is a new mechanism for evolution that ha...ementary molecule (that the scientists have called antisense RNA) joins with the normal RNA of the gene obstructing it from synthesising the protein. Even though...Study suggests first molecular target to halt spread of HPV
...titled "The Inhibition of papilloma progression by antisense oligonucleaotides targeted to HPV11 E6/E7 RNA" was...geted the sites identified on HPV 11 with ASO407 - antisense oligonucleotide 407 - and/or DNAzymes, both of which are small pieces of DNA - the body's genetic in......iana attenuata, to express LOX3, HPL and AOS in an antisense orientation. All three enzymes are key regulators in the oxylipin pathway (see Figure below) and are known to play major roles in the plants' wound recognition. However, their defensive function has only been tested in laboratory studies. When plante...JCI table of contents, 1 June 2004
...mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors AUTHOR CONTACT: Kyle W. Sloop Lily Research Laboratories Indianapolis, Indiana, USA Phone: 317-651-2856; Fax: 317-276-9086 E-mail: sloop_kyle_w@lilly.com View the PDF of this article at: https://www.the-jci.org/press/2...Bim notes in the neuronal executioner's song
... Blocking upstream activators of Bim or using Bim antisense to block Bim expression reduced neuronal damage. Of interest, in the hippocampus of epileptic patients, Bim appeared to be selectively down-regulated. These results suggest a means by which the brain may protect itself from additional neural damage...JCI table of contents, 2 April 2004
... Blocking upstream activators of Bim or using Bim antisense to block Bim expression reduced neuronal damage. Of interest, in the hippocampus of epileptic patients, Bim appeared to be selectively down-regulated. These results suggest a means by which the brain may protect itself from additional neural damage...Other highlights in the January 21 issue of JNCI
...authors write. "Furthermore, our data suggest that antisense inhibition of MTHFR may be a potential target for increasing chemosensitivity of colon and breast cancer cells to 5FU-based chemotherapy." Titles of additional articles appearing in the January 21 JNCI: Exposure to carcinogens not proportionall...Avoid bad memories: Targeting genes and drugs
...ce. Injection of the acetylcholinesterase-targeted antisense agent to the brain of mice prior to the stress exposure suppressed the change in gene expression, prevented neuronal intensified signaling and attenuated the elevated freezing response, proving that the detected change was causally involved with the ...Scientists report on promising new approaches to induce cancer cell suicide
...ervix, skin and brain. "We believe that the use of antisense molecules against targets such as survivin are a v...e skin. Intravenous administration of the survivin antisense molecule LY2181308 to tumor-bearing nude mice significantly inhibited tumor growth compared to anima...'Timeless' gene found to play key role as timekeeper in mammals
... the presence of timeless. When specially designed antisense molecules were added to block it, electrical rhythms were disrupted. "When you have really low levels of timeless, you also disrupt the other clock genes," Barnes said. "You get an uncoupling. The clock is very much in disarray." Some clock genes se...Curcumin may be an inexpensive, well-tolerated, and effective therapy for inflammatory bowel disease
...zine, and 5-aminosalicylates (5-ASA). Furthermore, antisense oligonucleotides directed against the p65 subunit (a polypeptide contributing to the activation of NF- B) have been shown to diminish disease activity in an animal model of colitis. Recent work has shown that dietary constituents such as curcumin may...Gene newly identified by Columbia researchers may improve hair removal
...gy will be to use products containing ribozymes or antisense RNAs. These are molecules tailor-made to stick tig... materials. By binding to the RNA in this way, the antisense molecule inactivates it, and thus the protein it encodes will notbe made. One of the regulatory ge...Scientists investigate several techniques to achieve successful gene therapy
...investigate methods such as transcription factors, antisense inhibition or RNA interference, and gene repair to regulate expression without the transfer of genes. Vectors that target particular tissue and cell types to avoid the systemic exposure and side effects such as those seen in current chemotherapy prot...Carnegie Mellon scientists create unique DNA probe with great potential
... diagnostic tests, so-called "gene chips," and the antisense approach to gene therapy. In contrast, homologous hybridization is restricted to a relatively small number of sequences. Nevertheless, the importance of G-rich sequences such as those successfully targeted by the Carnegie Mellon researchers continues...