Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
...ns," which together hit the tumor with generalized antitumor chemicals, such as interferon and tumor necrosis factor, as well as activated T-cells that attack and kill the tumor, Portnoy said. "Listeria is the best bug so far to induce that response. With listeria, innate and acquired immunity work in concert....Advances in tumor angiogenesis Dendritic cells co-opted to the dark side
...tic cells play a central role in the generation of antitumor immune response," says Coukos. "As a result, it wa...rough angiogenesis but also through suppression of antitumor immune response, because these dendritic cells lose their ability to induce tumor rejection, which i...JCI table of contents, 2 August, 2004
...ine kinase inhibitors leading to NK cell-dependent antitumor effects AUTHOR CONTACT: Laurence Zitvogel INSERM, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France Phone: 33-1-42-11-50-41; Fax: 33-1-42-11-60-94; E-mail: zitvogel@igr.fr View the PDF of this article at: https://www.the-jci.org/press/211...Other highlights in the July 7 JNCI
...rcinoma. When delivered orally, RPI-1 had a strong antitumor effect. The authors conclude that RPI-1's antitumor efficacy and oral bioavailability make it potentially useful to target Ret oncoproteins in humans. I...Researchers identify genetic markers to predict response to chemotherapy for colorectal cancer
...the other two UGT genes and either side effects or antitumor response. "In reality, physicians will soon be able to personalize cancer therapies based on the tumor's characteristics and the genetic profile of the person," said Carlini. "The ultimate goal is to tailor treatment that offers the most anti-tumor...JCI table of contents, 1 June 2004
... as a tumor suppressor and aids IL-12 action as an antitumor agent. TITLE: The IL-12Rbeta2 gene functions as a tumor suppressor in human B cell malignancies AUTHOR CONTACT: Irma Airoldi G. Gaslini Institute Genoa, Italy Phone: 39-010-563-6342; Fax: 39-010-563-6524 E-mail: laboncologia@ospedale-gaslini.ge.it...JCI table of contents, 2 April 2004
... that EC apoptosis was largely responsible for the antitumor effects. Liver analysis further indicated the apoptotic effects were specific to ECs, and the EC-expression restriction of apoptosis enhanced transgene stability by dodging the humoral response. This approach to gene therapy offers the promise of imp...JCI table of contents, March 1 2004
...**************************************** Boosting antitumor immunity Despite the initial excitement over canc...es in cancer patients." TITLE: Induction of potent antitumor immunity by in situ targeting of intratumoral DCs AUTHOR CONTACT: Edgar Engleman Stanford Universit...Inhibition of insulin-like growth factor receptor-1 as promising anticancer therapeutic
...R inhibition using a variety of methods had potent antitumor effects against many types of cancer cells grown i... tumor growth, prolongs survival, and enhances the antitumor effect of chemotherapy in clinically relevant mouse models of multiple myeloma and other hematologic...JCI table of contents, 16 February 2004
... may be an ideal target for the development of new antitumor therapies. In an accompanying commentary, Steven Clarke and Fuyuhiko Tamanoi from the University of California discuss current approaches underway attempting to inhibit cellular methylation a promising approach to anticancer therapy. TITLE: Inacti...JCI table of contents, February 2, 2004
...quires self-tolerance while eliciting an effective antitumor response. In an effort to design the ideal vaccine...vaccination efficiency of low-affinity epitopes in antitumor immunotherapy AUTHOR CONTACT: David-Alexandre Gross Institut Gustave Roussy, Cedex, France. Phone: ...JCI table of contents, 15 October, 2003
...h, tumor blood vessels are recognized as potential antitumor drug targets. Previous studies have demonstrated that pericyte recruitment to blood vessels during normal angiogenesis depends on interaction between the growth factor PDGF-B, expressed by ECs, and PDGF-Rbeta, expressed by pericytes. It has however b...JCI table of contents, July 15, 2003
...s, Ohio, report that the cytokine IFN-a exerts its antitumor actions primarily via its ability to stimulate imm...and not within the tumor cells, which mediates the antitumor effects of IFN-a therapy. These investigations may ultimately permit the identification of character...Silent DNA architecture helps block cancer cell growth
...cer chemotherapy is to help stimulate these potent antitumor processes. Researchers at Cold Spring Harbor Labor... suppression of cancer cell growth is an important antitumor response. Now that we have a handle on the precise mechanism of the response, we hope to ultimately ...JCI table of contents, 2 June, 2003
...ble that is able to cure cancer. The success of an antitumor vaccine will depend on its ability to induce robus...mmune responses. There is evidence to suggest that antitumor vaccination can induce such responses and even tumor regression. However, to date these regressions ...Turning foe into friend with lentiviral vectors
...ble that is able to cure cancer. The success of an antitumor vaccine will depend on its ability to induce robus...mmune responses. There is evidence to suggest that antitumor vaccination can induce such responses and even tumor regression. However, to date these regressions ...Virginia Tech inventions, creations can improve lives
...er. The natural product paclitaxel is an effective antitumor drug against breast and ovarian cancer and some lung cancer; however, there is a limited natural supply of paclitaxel. The Kingston group's analogs have different substituents than paclitaxel at the 2 and 4 positions, and these differences result in ...Arthritis drug suppresses cancer development by stopping action of key protein
...esults provide a novel molecular mechanism for the antitumor activity of celecoxib," says Keping Xie, M.D., Ph....ich correlated with reduced VEGF expression. "The antitumor activity was consistent with inhibition of angiogenesis as determined by evaluating tumor microvesse...Treatment of lupus in mice may point the way to human treatment
...sses the growth of prostate cancer; THA has potent antitumor activity in breast cancer. "Investigation of the potential role of these agents in autoimmune diseases are just beginning," said Mishra. He said that Christopher M. Reilly of the Medical University of South Carolina, a member of the laborato...Vaccine technique shows potential against common form of lung cancer
...e results demonstrate that the technique can raise antitumor immunity in some patients with NSCLC," states Dranoff, who is also an associate professor of medicine at Harvard Medical School. "It is important to keep these findings in proper perspective: they are promising but still preliminary. More research ne...