USAMRIID scientist Peter B. Jahrling elected fellow by AAAS
...a, and Lassa viruses leading to improved vaccines, antiviral drugs, and diagnostics. He is one of 348 members to be recognized this year. According to the association's news release, new Fellows are selected on the basis of their efforts to advance research or applications that are deemed scientifically or so...'Kissing' RNA and HIV-1: Unraveling the details
...ademy of Sciences , might provide a new target for antiviral drugs. The finding is among several to emerge recently from CARB's efforts to develop and validate sensitive tools for rapidly detecting and quantifying ribonucleic acid (RNA) interactions. RNA provides the genetic blueprint for retroviruses such as ...Results of pivotal study for GlaxoSmithKline's Valtrex published in New England Journal of Medicine
...ommented: "This is the first demonstration that an antiviral medication can reduce the transmission of a sexually transmitted chronic viral infection. As genital herpes is widespread in nearly all parts of the world, these results offer an additional approach for both patients and healthcare providers for wha...Purdue biologists expose the inner workings of viral machine
...lso could have implications for the development of antiviral agents. Using improved microscope technology, a te... scientists figure out how to develop an effective antiviral to stop the process." With modifications, the viral particles might be used to treat other diseases....Drug shows promise for Ebola virus treatment in primates
...e untreated animals died. Previous attempts to use antiviral drugs to treat Ebola have demonstrated success in mice and guinea pigs, but not in primates. Geisbert's team approached the problem a different way--by focusing on the symptoms triggered by the virus, rather than the virus itself. Ebola causes coa...US develops lethal new viruses
... virus kills all mice even if they have been given antiviral drugs as well as a vaccine that would normally pro...ed mice, even when they were also treated with the antiviral drug cidofovir. A monoclonal antibody that mops up IL-4 did save some, however. His team "optimised"...Experimental hantavirus vaccine elicits strong antibody response in primates
... endemic areas. Currently there are no vaccines or antiviral drugs to protect against or treat HPS. The disease affects previously healthy individuals in all age groups, disease progression is rapid, and the case fatality rate is one of the highest for any acute viral disease known. In addition, there have b...Proteins enable HIV to override cell's defenses
... is essential for evading the human cell's natural antiviral agent called APOBEC3G. To disable the antiviral agent, Vif interacts with a series of proteins to modify (polyubiquitination) and degrade APOBEC3G. ...HIV protein attacks body's innate protection system that could prevent virus' replication
...l infectivity factor, or Vif neutralizes a potent antiviral human protein called APOBEC3G that would, in the a...about Vif that suggested the existence of a potent antiviral defense system in human lymphocytes, and that it was Vif's job to destroy it. "We knew what to look ...Purdue biologists receive nearly $18 million to study infectious diseases
...earch on viruses and also speed the development of antiviral agents that could stem from this basic research. R...n, as it is designed to support the development of antiviral compounds that might be made possible by the researchers' work. The project is part of a larger $350......00 cells per microliter in AIDS patients receiving antiviral treatment. "Historically, it was clear that HIV killed white blood cells, but it took a while to figure out how," Planelles says. "We don't know it completely yet. But by 1995, we figured out that the vpr gene was major factor in killing the cells. ...OHSU researchers publish final results of groundbreaking smallpox vaccination study
...s post-vaccination. The second form of immunity is antiviral T-cells programmed by the vaccine to attack the smallpox virus. In study participants, antiviral T-cell levels declined slowly over time with a half-life of approximately 8 to 15 years. "We found...SARS information for antiviral drug design released by Protein Data Bank
...is enzyme is considered the primary target for new antiviral drugs being developed to combat the virus. "The PDB was able to process and release this information so quickly because of the leading-edge technology it employs," said Rutgers Board of Governors Professor of Chemistry and Chemical Biology Helen M. ...First-ever images of developing dengue virus obtained at Purdue
...e that could prove important to the development of antiviral drugs. A team including Purdue University's Micha...ssembly process provides a potential target for an antiviral agent," Rossmann said. "If you are trying to assemble something, introducing a foreign body into the...Scientists develop new RNAi knockdown technology
...use of RNAi in mammals has been complicated by the antiviral response of mammalian cells to dsRNA. The presence of foreign dsRNA in a mammalian cell initiates the so-called "interferon response:" the non-specific degradation of mRNA, and ensuing death of the cell. Mammalian RNAi researchers have undertaken a f...Hopkins researchers find potential new treatment for children with chronic hepatitis C
...rferon alone, or in combination with ribavirin, an antiviral medication, which is the current treatment of choice for adults with CHC," she said. "Such a study will be necessary before the Food and Drug Administration can approve the drug for children." Some children with CHC have been treated with three shots...Columbia investigators win 2003 Gairdner International Award for research
...ction, opening a new approach to the design of HIV antiviral drugs. Other 2003 award recipients include Dr. Seiji Ogawa, director of Ogawa Laboratories for Brain Function Research, Hamano Life Science Research Foundation, Tokyo, for his seminal work in functional magnetic resonance imaging (fMRI), a non-invas...New drugs restore immune response blocked by hepatitis C virus in human cells
...s immune response and basically restore the innate antiviral response in human cells," said Dr. Michael Gale, assistant professor of microbiology at UT Southwestern and senior author of the study, published online today in Science Express. "Our conclusion is that these new drugs will have a dual efficacy." Pro...Key to hepatitis virus persistence found
...ry factor-3 (IRF-3). IRF-3 orchestrates a range of antiviral responses. Without this master switch, antiviral responses never begin, and HCV can gain a foothold and persist in its host. Next, the scientists se...Achillion and UMBC collaboration identifies new class of agents with potential to treat HIV
...e building to treat infectious diseases, including antiviral drugs to treat hepatitis B and C viruses (HBV and HCV) and HIV. Achillion will continue to collaborate with Dr. Summers' team to identify additional candidates for optimization and clinical testing." The discovery is all the more remarkable consideri...