Tag: "antiviral" at biology news

New Drug "Cocktails" Prove Effective Against Hepatitis

...n 900 chronic Hepatitis C patients who had not had antiviral therapy before. Half the patients were given a daily dose of the Interferon alfa-2b and ribavirin (Rebetol) combinationfor 24 or 48 weeks, while the other half were given interferon alone.Those patients who received the combination did much better th...

Experts Say That Future Inhaled Anti-Viral Drug, Zanamivir Is Effective For Treatment And Prevention Of Influenza

...on of the influenza infection. "Zanamivir is a new antiviral that stops influenza dead in its tracks," saidProfessor Chris Silagy, Flinders Medical Centre, South Australia. "It is givenby the inhaled route so the medicine goes straight to where the influenza virusinfects the body -- in the breathing passages....

Phase III Results Suggest Potent Antiviral Activity For Vertex And Glaxo Wellcomes Second-Generation HIV Protease Inhibitor Agenerase TM

...ing other therapies in theregimen. Assessments of antiviral activity and safety will continue until thelast subject completes 48 weeks on study. "The considerable body of data now available suggests that Agenerase iswell-suited to the current standard of care and the need for simplerregimens," commented Dr. ...

Long-Term Study Looks At HIV Positive Men With Few Signs Of Disease Progression, 10-18 Years After Seroconversion

...lasma viral loads, includingLTNPs, should consider antiviral therapy to keep themselves healthy, theresearchers said. Susan Buchbinder, MD, principal investigator of the San Francisco City ClinicCohort Study, director of the HIV Research Section in the San FranciscoDepartment of Public Health, and assistant cl...

New Tests Demonstrate MuchLarger, More Specific Immune Responses To Viruses

...omeasure these responses. "The size of the antiviral response is much greater than our previousestimates, and radically changes our perception of the T cell response toviruses," says Dr. Ahmed. "This research should prove very important forvaccine development, because you want a vaccine to induce a go...

New Model Makes It Possible To Predict Emergence Of Antiviral Drug Resistance

...e developed a model forpredicting the emergence of antiviral drug resistance and for identifying thekey factors that generate drug resistance. The model, reported in the June 1 issue of Nature Medicine and lauded in anaccompanying review by a Yale School of Management professor of managementsciences and medici...

Leading HIV Researcher Identifies Molecular Mechanism That Enhances NaturalImmune Defense Against HIV Infection

...f virus,which is enough to get the cellular immune antiviral response going," said Levy. "Each subsequent expos... said theresearchers do not know why the CD8+ cell antiviral response occurs in somepeople and not in others. In the second study from the Levy laboratory presen...

Researchers Take Major Step Toward Cracking Ebola Code

...ease in infected individuals and point topotential antiviral targets," Nabel says. Research is now under way on how the glycoprotein causes disease in animals. Nabel says investigators can look for potential treatment strategies that wouldactivate the inflammatory defense system (to counteract the secretedglyc...

Extensive Phase II Data Of Amprenavir (141W94/VX-478) To Be Presented

... PI combination data shows high potency and arapid antiviral effect (80% of patients with undetectable virus at...16-week data will be presented, showing asustained antiviral effect as measured by the percentage of patients withundetectable virus. Data will be presented at ...

Fauci: New Findings Help Explain "Rebound" Of HIV In Patients Who Discontinue Triple-Drug Therapy

...unable to infect new cells because of the powerful antiviral effects of the drugs. Thus, HAART together with IL-2 would lead to a depletion of latently infected cells. In the experiments, the researchers found that latently infected CD4+ T cells that contained inducible v...

Harvard Medical School Researchers Present Atomic Structure Of DNA-Replicating Enzyme Widely Used In DNA Sequencing

...s whodevelop drugs targeting DNA replication. Many antiviral drugs, including theAIDS drug AZT and drugs against herpes simplex virus, inhibit DNA polymerase. Inaddition, this work may guide the development of better reagents for DNAsequencing--highly sought-after products in this age of the Human Genome Proje...

Vertex Pharmaceuticals Researchers Report Three-Dimensional Structure Of Hepatitis C Helicase Enzyme; Report In Structure

...on to designhepatitis C helicase inhibitors as new antiviral drugs to treat hepatitis Cvirus (HCV) infection. "This paper presents for the first time detailed information on the criticalinteraction between the hepatitis C helicase and viral RNA," said Dr. Joseph L.Kim, Vertex crystallographer and an author o...

3-D Structure Of HIV Components May Pave The Way For New Anti-AIDS Drugs

...mmers. "Nucleocapsid has already been targeted by antiviral agentsthat eject zinc from the protein, some of which are undergoing clinical tests inthe U.S. and U.K.," he said. Even more effective drugs may be designed specifically to block the molecularembrace between nucleocapsid and RNA. Molecular details...

Virologists Track New Influenza Threat

...on, the scientists will take an antiviral drug called rimantadine, which blocks infection from the virus. Kawaoka said identifying the virus in birds and comparing it with the human cases will help determine whether any genetic ...

Herpes Virus Strain Identified As A Trigger In Multiple Sclerosis

... Medicine(1). "We expect that currently available antiviral treatments--for example,acyclovir--might one day be applied successfully to MS," said Steven Jacobson,Ph.D., Chief of the NINDS Viral Immunology Section and the study's principalinvestigator. "We've suspected a possible role for a virus in MS for qu...

Northwestern Scientists Discover How Herpes Simplex Virus Infects Cells

...tems and will lead todevelopment of new classes of antiviral drugs," said Patricia G. Spear, whoheads the laboratory at Northwestern where the discovery was made. Spear isthe Guy and Anne Youmans Professor and chair of the department ofmicrobiology-immunology at Northwestern. Herpes simplex virus is highlypre...

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