Cell death protein has surprising role in cell migration
...e on the short list, too, since cells have to take apart and rebuild their skeletons in order to move. "If these obvious choices don't pan out, we'll go back to a forward genetic screen," says Montell. "Then we can let the animal tell us what is happening." As always, Montell and her colleagues will use ...Oxygen sensing in worms may hold key to healthy blood pressure in humans
...it is used as a cell-killing agent. "When we took apart the guanylate cyclase protein to study nitric oxide signaling, we found that the binding site is a heme molecule almost identical to the heme molecule that gives hemoglobin its red color and binds to oxygen," says Marletta. "However, whereas the heme...Researchers discover how worms' noses sense oxygen
...aid. Marletta's students have painstakingly picked apart the guanylate cyclase protein, in particular the e...gen levels." Marletta's students continue to take apart the guanylate cyclase enzyme and, working with Kuriyan, are trying to crystallize the pieces in orde...Basic RNA enzyme research promises single-molecule biosensors
ANN ARBOR, Mich.---Research aimed at teasing apart the workings of RNA enzymes eventually may lead to ways of monitoring fat metabolism and might even assist in the search for signs of life on Mars, according to University of Michigan researcher Nils Walter. His latest work was published online in ...Myths surrounding Cuyahoga River fire 35 years ago
...he Rouge River in Michigan. What set the Cuyahoga apart from other fires is that the nation's attention had begun to focus on the environment, and the Cleveland fire fueled the symbolism of the earth's need for repair and the necessary federal regulation to do so, said Adler. The fire led to the passage ...UCLA researchers recreate patterns formed by mammalian cells
...t was a bit magical how cells knew exactly how far apart to space ribs or tiger stripes," said Dr. Linda L. Demer, senior investigator, Guthman Professor of Medicine and Physiology, and vice chair for cardiovascular and vascular medicine at the David Geffen School of Medicine at UCLA. "We now know that i...Kangaroo hops in line for genome sequencing
...ls. In addition to sequencing species that are far apart on the evolutionary tree, it is important to sequence sets of species that are closely related. Having two marsupial genomes, separated by 70-80 million years of evolution, will provide scientists with data sets that should allow them to make more pr...Proteins transform DNA into 'molecular velcro'
...n," said Bustamante. "And when we began to pull it apart carefully, we saw it extend in a sawtooth pattern ...tched the DNA molecule, the condensin heads popped apart sequentially, producing the sawtooth force extension pattern. But the heads remained bound to the DN...Two dinosaurs from Africa give clues to continents' split
...tinents that formed Gondwana separated and drifted apart over a narrow interval of time, about 100 million years ago. Coauthor and team member Jeffrey Wilson, assistant professor at the University of Michigan, said, "Until the continents fully separated, dinosaurs like Rugops and other animals used narrow ...Indoor mold, building dampness linked to respiratory problems and require better prevention
...e it clear to us that it can be very hard to tease apart the health effects of exposure to mold from all the other factors that may be influencing health in the typical indoor environment," said committee chair Noreen Clark, dean, School of Public Health, University of Michigan, Ann Arbor. "That said, we ...Study helps satellites measure Great Lakes' water quality
...an one percent. What set the top-performing models apart was how well they enabled the engineers to remove the interference of atmospheric molecules. Over the ocean, carbon dioxide, ozone, and humidity are fairly constant, but amounts of these molecules fluctuate dramatically over lakes depending on the we...Discovery in parasite movement may offer insights into malaria
...ll the rope and no net movement will occur." Thus, apart from having identified a complex of proteins containing a major myosin in Toxoplasma, the new study has "gone one step further because we identified a protein that actually anchors this myosin-containing complex in the membrane. And this protein is a...Researchers discover protein that dissolves amyloid fibers
...one has found anything that can catalytically take apart an amyloid fiber." The finding follows years of...ilient structure, the fact that a protein can take apart these amyloids is remarkable," says Lindquist. "It has huge implications for our understanding of th...Scientists track protein linked to movement disorder
...re this means torsinA is probably taking something apart in the nuclear envelope," Hanson says. "The questions are: What is it taking apart and how is that important for the normal structure and function of the nuclear envelope? And how is...Plant-like enzyme acts as key life cycle switch in malaria parasite
... the male gametes only." "CDPK4 is unusual because apart from the malaria parasite and some other single-celled organisms, it is only seen in plants. This makes it appealing as a target for drug developers, who would not run such a big risk of developing a drug with strong side effects, because CDPK4-like ...White House lauds Physiological Society for mentoring underrepresented minorities in biomedicine
...nal Director: "What sets the APS diversity efforts apart is that all of our programs from preschool through graduate education are carefully designed to encourage active participation by minority participants and are evaluated regularly for their impact and effectiveness," she said. "As a result, APS eff...Staying close to mother helps baby dolphins swim
...arios, such as what happens when the dolphins move apart or propel themselves along by flapping their tails...calf connection," as the dolphin pair have to move apart when they accelerate to avoid hurting each other as they increase their body movements. Weihs' findi...Measurement clarifies role between protein structure and cell adhesion
...ons may serve as scaffolds that hold the membranes apart and regulate the intercellular space," Leckband said. "The scaffolds would allow some molecules in -- like some proteins that activate the immune response -- while excluding others."...Stretching DNA on a tiny scale, researchers probe the basis for its compaction
... the DNA reversed compaction, effectively breaking apart the molecular interactions formed by Condensin. Carefully measuring changes in distance between the two ends of the DNA molecule revealed evidence that both compaction and decompaction often occurred in jumps of certain lengths. Comparing the range o...HHMI commits more than $30 million to help reverse brain drain, beat infectious diseases
...rchers in less and more developed countries as far apart as Mexico and Australia. "The impact of HHMI funding goes well beyond the research of individual scientists," Conley says. "It actually has enabled them to affect science policy in their countries and regions." For example, Carlos Reinach became Secr...