Study reveals genetic activity of key step in malaria parasite's cycle
...e pattern of expression revealed sets the organism apart from all other known one-celled organisms, says DeRisi. "Most of the genes were expressed just once in a cycle and in a particular order." Genes expressed in the early phases appeared to code for proteins involved in metabolic functions. Many of thos...Purdue Research Park company makes melt-in-your-mouth meds
...ing this technique, the formed tablets won't break apart easily and they remain intact even when dropped from 6 feet onto a hard surface, Park said. Fast-melting tablets on the market today must be packaged individually, but tablets manufactured using the Frosta(tm) technology are strong and stable enough ...Animal studies show CA4P suppresses development and induces regression of ocular neovascularization
...ression of established CNV, a finding that sets it apart from other drugs. To our knowledge, intraocular gene transfer of pigment epithelium-derived factor (PEDF) is the only other gene-therapy-based or drug treatment that has been shown conclusively to cause partial regression of CNV, and therefore CA-4-...'Unzipping' double helix to study protein-DNA interaction
...lly metered dynamic force -- is the key to pulling apart two strands of the DNA "zipper" and popping loose restriction enzymes and other proteins along the way. A report in the journal Physical Review Letters ( PRL Vol.91, No.2, July 11, 2003) by Steven J. Koch and Michelle D. Wang, titled "Dynamic Fo...... lot of water to puff themselves up and then crack apart and discard their old shells. Within a day, their outer membrane, which is called the cuticle, begins to toughen and harden. In experiments Taylor conducted under Kier's supervision, the researchers found that internal pressures were temporarily far ...Circadian influence in plants more widespread than previously thought
HANOVER, NH While picking apart the genetic makeup of the plant Arabidopsis, two Dartmouth researchers made a startling discovery. They found that approximately 36 percent of its genome is potentially regulated by the circadian clock, which is three and a half times more than had p...Scientists find what type of genes affect longevity
...g the power of DNA microarray analysis for teasing apart complex systems. Kenyon's team discovered ten years ago that a single mutation in the daf-2 gene, which encodes a hormone receptor similar to the human receptors for the hormones insulin and IGF-1, doubled the worms' lifespan. The same or related h...Molecular fingerprint predicts HIV-associated dementia
...inct protein patterns in their blood, setting them apart from patients with no symptoms of dementia. The study suggests a possible way to screen HIV patients for the first signs of cognitive impairment. "Characterizing dementia in this way is a very new and exciting approach," says study author Loyda Mele...Body clocks keep migrating monarchs on course, Science study shows
...eup of the monarch circadian clock will help tease apart the entire migratory process, a process that remains one of the great mysteries of biology." Research in other animals has been turning up a number of genes that make up the circadian clock, as their expression oscillates in a daily cycle. The clock ...Controlling cell adhesion: Researchers report first evidence of 'catch bonds'
...expect when you apply a larger force, things come apart faster." In making the measurements, Marshall carefully picked up only the effects of the interaction between P-selectin and PSGL-1 and shielded the instrument from thermal fluctuations that produce forces greater than those he was trying to measure....Microgel polymer beads may provide general vehicle for vaccines, gene therapy
...nd their colleagues, designed a polymer that falls apart in acid to form thousands of little molecules that... bead that would, under the right conditions, fall apart into so many pieces that osmotic pressure - the tendency of water to rush in to dilute concentration...An unexplored genomic terrain in a handful of dirt
...ific "linker" sequences at which genes are snipped apart for recombination. However Jacobs, Hatfull and their colleagues found more persuasive genomic evidence for the "illegitimate recombination" theory, in which the phage genes undergo nearly random cutting and splicing, with the resulting phage genomes ...The roots of human behavior? AAAS and The Hastings Center host a public meeting
... we have very little ability to understand or pull apart how any of those individual genes contribute to television watching," he says. Nor is identifying specific genes necessarily required for studying the causes of behavioral disorders, according to Hyman. "We should really be focused on understanding ...Mother-infant bed sharing is associated with an increase in infant heart rate
...y also impact other types of infant health issues, apart from SIDS. Despite this concern, many mothers believe that the infant's sensory and social environment during bed sharing is enriched compared to that found during solitary sleeping. The study of mother-infant bed sharing is still a nascent area ...In a noisy world, how can the senses project and receive information at the same time?
... male G. bimaculatus, where individuals are spaced apart by two meters on average, the ability to hear during singing will be an advantage. It would allow males to defend their territory from rival singing males, to maintain a fixed distance from each other, and to hear noisy predators This strongly sugges...Promising new tool shows how dividing cells finish what they start
... said. "The same thing that is pulling chromosomes apart is making sure that cells divide in the proper place so that the genetic material gets equally segregated into the two daughter cells." Blebbistatin was discovered by screening 17,000 small molecules in the chemical library of the HMS Institute of Ch...Richard A. Lerner and Peter G. Schultz to receive Paul Ehrlich and Ludwig Darmstaedter Prize 2003
...rmediate. "The discovery that natural antibodies-- apart from their binding function-- also possess reactive properties, leads to a change in paradigms with regard to their role in the immune system," says Manfred Eigen....Pacific Northwest chemist wins national award for studies of biological systems
...acked with chemically sensitive "beads" that tease apart mixtures according to size, electrical charge and other molecular properties. Once separated, Smith and his research team analyze the various components with a powerful mass spectrometer. "We developed this technique to identify the molecules and do ...Evolution boosted anti-cancer prowess of a primordial gene
...its reach and inhibit many more cellular responses apart from ribosome synthesis." Sherr is senior author of a report on these findings published in the February 2003 issue of Molecular Cell. Other authors of the study include Masataka Sugimoto, Mei-Ling Kuo and Martine F. Roussel, all of whom are St. Jude...Dartmouth Medical School geneticists discover new role for antisense RNA
...read mold Neurospora, Dunlap and Loros have teased apart the molecular gears that form the basis of most living clocks. Light and dark cycles reset the clocks, they found, the way turning the hands of a clock does. The clock mechanism, a biological oscillator, keeps time through the delicately balanced i...