Chemical derived from vitamin-E shows early promise as cancer drug
...r cells to shrink and die through a process called apoptosis compared to untreated breast cancer cells. "One reason that alpha-TEA is such a potent anti-cancer agent is that it impacts on numerous anti-growth and pro-death cellular processes in cancer cells but not normal cells," said Kline. T...New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
...works by causing changes in cancer cells, inducing apoptosis programmed cell death. It also appears to correct the gene responsible for making a flawed protein (the PMLRAR fusion protein) that causes APL. The research team used RT-PCR2 techniques to confirm the diagnosis of APL by identifying the rogue gene ...Phase II trials of second-generation antisense cancer drug planned following successful early study
... is implicated in a range of activities, including apoptosis (programmed cell death). When it is over-produced, as it is many major cancers, clusterin can stop cancer cells from dying and counters the effectiveness of chemotherapy, hormone treatment and radiotherapy. Dr. Kim Chi, assistant professor of medicin...Protein is key to fatal disorder and normal cell function
...sing from the lipid platforms at the cell surface, apoptosis is inappropriately initiated and proceeds uncontrolled, resulting in death of brain cells and the clinical deterioration of juvenile Batten disease. "We may be able to devise a way to treat juvenile neuronal ceroid lipofuscinosis [Batten disease] by ...Growth hormone and IBD: Reduction of intestinal inflammation, promotion of growth
...ne reduces STAT3 activation and modulates cellular apoptosis and proliferation in murine colitis" at an IBD tra...ases in either serum or colon IGF-1. GH increased apoptosis of lamina propria mononuclear cells (LPMC), while reducing apoptosis and increasing proliferation of...Breaking new ground in germ cell guidance
...sociated with programmed cell death activation of apoptosis mediator, caspase-3. Hanyu-Nakamura et al. pinpointed the site of the mutation to the locus for the guidance gene, wunen2 . The products of this gene and its relative, wunen , have been known for some time to play important roles in the guidance of D......led Smac, which promotes apoptosis. Normally, when apoptosis is activated in cells that are damaged or no longe...roup of gatekeeper proteins known as "inhibitor of apoptosis proteins" (IAPs), which normally hold in check the cell's chief executioner enzymes. These enzymes, ...News tips from the Journal of Neuroscience
...ay mediates Bax activation and subsequent neuronal apoptosis through interaction with bim after transient focal...) pathway may be an early step leading to neuronal apoptosis via mitochondrial apoptosis-related proteins. Proapoptotic proteins of the BcL-2 family, like Bax, c...Optimizing protein's 'death domain' halts leukemia in laboratory study
...when it should be dying. The pro-death part of the apoptosis toolbox includes a number of molecules known as BH3-only proteins. To ensure that cells destroy themselves when appropriate, despite contrary signals from anti-death molecules, BH3-only proteins contain a peptide subunit, termed "BH3", that is made o...Molecular staples shape a cancer killer
...is-triggering protein called BID that could induce apoptosis in cancer cells. Their objective was to create a short peptide that functionally mimicked the specific region of the BID protein that elicits cell death. Theoretically, such a small molecule -- basically a short string of amino acids -- could insinua...APS awards more than $140,000 to minority students of physiology
...nvestigate how the hepatitis B Virus (HBV) induces apoptosis (cell death) in liver cells. His lab suspects that...kinase C- (PKC-) and PKC- play an integral role in apoptosis through their interaction with hepatitis B X (HBx), a viral transactivator expressed during HBV infe...New compound could give some types of cancer the one-two punch
... division in its tracks," he said. OSU 111 induces apoptosis cell suicide in cancer cells because it keeps key structures called microtubules from working during cell division. Microtubules distribute chromosomes to new cells. OSU 111 also prevents tumor cells from forming new blood vessels. Scientists are l...Possible new cure for psoriasis
...spects the number of skin cells which entered into apoptosis remained constant apoptosis is the cells' 'suicide' programme, which enables them to self-destruct when they are malfunctioning....UCSD researchers are first to demonstrate molecular link between inflammation and cancer
...ts determined that stimulation of a process called apoptosis had decreased cancer development. A form of cell suicide, apoptosis prevents the growth of unwanted cells. It is a normal process the body uses to kill mutated or chem...Scientists identify molecular link driving spread of skin cancer
...umor cell metastasis and angiogenesis and increase apoptosis may be important in the development of therapeutics for malignancy," said Hynda Kleinman, Ph.D., chief, cell biology section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Md. As described in the...Gene therapy alternative to calcium channel blockers
...ypertrophy (uncontrolled growth of muscle tissue), apoptosis (programmed cell death) and cardiac remodeling. "Our hope is that further research and eventually human clinical trials will prove the benefits of gene therapies for the treatment of other ailments, and that these treatments will be specific to par...Chemoradioimmunotherapy for advanced breast cancer: hope for the future?
...tumour cells were undergoing significantly greater apoptosis than the untreated controls. Apoptosis was confirm...ent tumour cells, which resulted in the subsequent apoptosis of the tumour cells through a 'bystander' killing effect. Several diagnostic tests were employed to...New compound 'highly efficacious' at reducing human tumour growth
...eability, inhibits tumour angiogenesis and induces apoptosis in human tumour models said Dr. Gerhard Siemeister of Schering AG, Corporate Research, Berlin speaking at the 18th meeting of the European Association of Cancer Research today (Tuesday 6 July, 2004). Loss of cell cycle control (runaway growth) and tu...Scientist honored for studies of genetic influence on chemotherapy, tumor development
...ppressor gene are a primary cause of resistance to apoptosis in cancer cells, Dr. Lowe has shown that the p53 p..., Apaf-1 and capase-9, is responsible for inducing apoptosis in cancer cells in response to chemotherapeutic agents." NFCR science director Sujuan Ba, Ph....Lupus Research Institute awards $3 million in novel research grants to further new science in lupus
...e primary supplier of autoantigens for SLE, making apoptosis a potentially robust therapeutic target. This study aims to confirm the exact role that apoptotic nucleosomes play in the cause of SLE and pinpoint the source of this dangerous material. This work may provide a stronger rationale for targeting new ...