Tag: "apoptosis" at biology news

Proteins may help identify patients who will respond better to treatments in certain cancers

...ation of cell cycle progression, proliferation, or apoptosis (programmed cell death), which are known to affect the way that a tumor responds to radiotherapy. "We are using new strategies for data analysis to exploit the potential of molecular markers," said Francesca Buffa, PhD, of the Gray Cancer Institute ...

Circadian clock genes may provide targets for new cancer drugs

...any basic functions such as cell proliferation and apoptosis in circadian time, or within each day, according t...ls are responsible for initiating a process called apoptosis that results in the death of the damaged cell. "The cell with damaged DNA becomes cancerous because ...

Clock cells, tumor suicide, tailored therapies among subjects of AACR-NCI-EORTC Conference

...ler. One study shows that binding VEGF to the Fas apoptosis receptor, creating VEGFR2Fas, triggers the signal for cell death. Further investigation will seek to optimize this effect and determine the feasibility of using it in vivo to kill tumor cells and/or the blood vessels that fuel them directly. Improvi...

High heart risk for lupus patients linked to death of cells lining blood vessels

...al medicine who will present the study. "The rapid apoptosis of endothelial cells is apparently outpacing the b...d vessels. Loss of these cells through accelerated apoptosis may affect vascular and heart health in many ways, says Rajagopalan, since endothelial cells serve a...

JCI Table of Contents, November 3, 2003

...essing dendritic cells into these mice induced the apoptosis of collagen-specific T cells, a reduction in lymphokine production, and suppression of collagen-induced arthritis. The data suggest that this gene therapy regime is a safe and effective method for inhibiting the development of collagen-induced arthri...

Fruits offer powerful protection from skin cancer

...vision, and is a structurally unique member of the apoptosis inhibitors protein family. Survivin is overexpressed in most human cancers, but absent in normal adult tissues, and is considered a promising therapeutic target for novel anticancer therapies. Results of the study showed that resveratrol treatment ...

Studies show preventive value of food supplements

...In the study, researchers determined the extent of apoptosis (cell death) and necrosis (tissue death), as well ...rs is the optimal incubation time for SB to induce apoptosis in TRAMP-C1 cells. Mice were fed daily in random groups, either receiving sterile water as placebo ...

PTEN and prostate cancer--the devil is in the doses

...n signaling pathways that regulate cell growth and apoptosis in healthy tissue and contributes to cancer when dysfunctional. Humans, as diploid organisms, generally have two versions of most genes, including PTEN. In the event that one copy is damaged or lost, gene function is usually maintained by the other c...

Intraepithelial neoplasia may be a leading risk factor for prostate and ovarian cancers

...tissue, cell proliferation (reproduction) and cell apoptosis (cell death). Many studies have suggested that hi...erous. There was a significant increase from the apoptosis rate of normal tissue to that of cancer tissue, but apoptosis was very low in both LGPIN and HGPIN, ...

Novel therapeutic target identified in fight against Rheumatoid Arthritis

... unwanted cells. On the other hand, synovial cell apoptosis was significantly impaired in mice overexpressing synoviolin, promoting synovial hypoplasia and ultimately, joint disease. This research demonstrates the significance of synoviolin in regulating synovial hyperplasia and ultimately joint destruction...

Stem cells delivered into back of eye hold promise for people with retinitis pigmentosa

...ighters, says Friedlander. They are protected from apoptosis the way that a firefighter is protected from heat and flames by specialized gear. And the stem cells extend their protection to the surrounding cells of the retina, much as a firefighter, by protecting one position, might protect an entire area of a ...

Researchers try to determine why cancer cells don't commit suicide

...-programmed to kill themselves by a process called apoptosis if they grow too fast or at the wrong time or plac...ancer. "Defects in signaling pathways that control apoptosis are thought to be a requirement for the development and maintenance of cancer. However, the specifi...

JCI Table of Contents, 15 August 2003

... IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation AUTHOR CONTACT: Nicholas Topley University of Wales College of Medicine, Cardiff, United Kingdom. Phone: 44-29-20748432 Fax: 44-29-20748470 E-mail: topley@cf.ac.uk View the PDF of this article at: https://www.the-jci.or...

Salk news: gene therapy for Lou Gehrig's disease

...er of phosphorylated Akt molecules, which inhibits apoptosis by directly inhibiting different pro-apoptotic sig...decreased levels of a specific protein involved in apoptosis by more than 63 percent compared to untreated mice. Understanding this pathway led us to experiment ...

Protein: Getting to the meat of this essential element

...formation on adaptor/adapter/adaptin proteins, and apoptosis (programmed cell deathsuch as when the tissue between fingers of a fetus goes away) and tumor suppressors....

Fears of second-hand smoke confirmed

...potent source of oxidative stress, DNA damage, and apoptosis for HFL-1 (fibroblast) cells, and is most likely t... stress. A New Study Because oxidative stress and apoptosis are implicated in numerous processes, including aging, inflammation, and carcinogenesis, it is reaso...

JCI table of contents, July 15, 2003

... also demonstrate a direct link between hepatocyte apoptosis and fibrosis. The data suggests that inhibition of apoptosis and perhaps the lysosomal pathway of apoptosis are important in the prevention of fibrosis and a num...

Cyclacel's biomarker technology shows that CYC202 induces cancer cells to commit suicide

...andidate, appears to induce cancer cell suicide or apoptosis in patients receiving the drug. Details of the bi...analysed) tested positive for cancer cell death or apoptosis following single agent treatment with the drug. In addition, seven CYC202 Phase I patients with var...

Researchers find new way to trigger self-destruction of certain cancer cells

...e finding suggests that drugs designed to activate apoptosis might be effective anti-cancer therapies. This str...ue of Molecular Cell. The St. Jude team stimulated apoptosis by treating cancer cells with a drug called rapamycin, which blocks the action of a protein called m...

JCI table of contents, May 15, 2003

...ure TITLE: A mechanistic role for cardiac myocyte apoptosis in heart failure AUTHOR CONTACT: Richard Kitsis Al... Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy AUTHOR CONTACT: Junichi Sadoshima New Jersey M...

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