Tag: "apoptosis" at biology news

Serendipity: Cell Structure Study Uncovers Taxol's Secrets

...2, Taxol stops the protein from working and allows apoptosis tocontinue. "It's a two-pronged attack against cancer cells," said Makowski,currently an NSF program manager in the division of biological infrastructure. "Taxol keeps cells from dividing, which halts cell growth, but then it alsobinds to mol...

Discovery Of Mutation May Lead To Help For Male Fertility Problems

... is involved in preventingapoptosis or whether the apoptosis is just a consequence of the germ cells notdeveloping the way they normally would," Zinn said. "Because of the nature of this mutation, it should berelatively easy to clone the morc gene, which may reveal a new regulatorymolecule involved in male r...

Idun Pharmaceuticals Identifies Cell Type And Molecular Pathway Involved In TransplantationRelated Liver Damage

...emia/reperfusion injury induces acaspase-dependent apoptosis in endothelial cells. Now that we have identifiedw...n. Thedata show that addition of IDN-1965 reduced apoptosis by 63 percent, as measuredby the TUNEL assay. "This research demonstrates that apoptosis plays a ro...

EMAP II: A Cytokine Regulated By Apoptosis

...ermany) have demonstrated a regulatory role for apoptosis in the processing of the EMAP II precursor to t...the presence of apoptotic cells. A high rate of apoptosis was detected in tissues with a strong EMAP II mRNA expression. The removal of dead cells during a...

UNC Researchers Reduce Arthritis Severity By Turning Off Molecular Switch

...y blocked NF kappa B and got a dramaticincrease in apoptosis of inflamed synovial tissue," he says. "It appears...e benefit by blocking inflammation andaccelerating apoptosis in the synovium. That's the way to make this tissueshrink." The study also yielded an unexpected res...

Cell Suicide Prevented By Survival Signals

...vered. "The Hid protein is a powerful inducer of apoptosis in mammaliancells, where it remains subject to sim...ls' access to survival signals andgradually causes apoptosis in millions of additional cells that survive theinitial insult. "It may be that the Hid pathway oper...

Press Briefings

...of epilepsy as humansand have profound evidence of apoptosis in their cerebellum. Thus, cystatian B,a cysteine protease inhibitor, plays a role in preventing apoptosis. Itsabsence results in cell death and epilepsy. Drs. Pennachio and Myers fromStanford University will discuss the work that will appear in t...

Paradoxical Gene Suppresses Tumors Yet Makes Them Grow

...ly prompts p53 to defend againstdeveloping tumors: apoptosis ? programmed cell death. The study examined micethat had been genetically engineered in Van Dyke?s laboratory to develop a typeof cancerous brain tumor that occurs rarely in people. Some of these"transgenic" mice were selectively bred not to have E2F...

Vertex Pharmaceuticals/Yale Research Team Uses Gene Knockout Mice To Establish Role Of Caspase-9 In Neuronal Cell Death Pathway

...ment in biochemical pathways ofinflammation and of apoptosis (also known as programmed cell death or cellsuicid...t Caspase-9 is activated early and is essentialfor apoptosis in neuronal cells, and that deletion of Caspase-9 does notinterfere with embryonic development of ot...

University Of Kentucky Chandler Medical Center Researchers Identify Protein That May Cause Nerve Cell Death In Alzheimer's Disease

...cuously present inprostate cancer cells undergoing apoptosis as a result of androgen(testosterone)removal. Testosterone removal is a common treatment for prostate cancer thatcan reduce the formation of tumors of the prostate gland in humans. Rangnekar said that Mattson became aware of his cancer resea...

Diabetes Drug And Accutane Block Breast Cancer Cell Growth, Cedars-Sinai Researchers Find

... in permanently inhibiting cellgrowth and inducing apoptosis (programmed cell death) in breast cancer cells. "Troglitazone alone has a mild effect on breast cancer cells. Accutane alone hasa mild effect on breast cancer cells. Together, they have a dramatic effect,"said Dr. H. Phillip Koeffler, Direc...

Targeted Genetics, M.D. Anderson Cancer Center And University Of Pittsburgh Report Phase I Clinical Trial Results Of Gene Therapy Treatment For Cancer

...trated E1A's ability tosuppress metastases, induce apoptosis (programmed cell death) and reverse theoverexpression of HER-2/neu, a cancer-causing gene. In patients with cancer,overexpression of the HER-2/neu oncogene is correlated with poor prognoses,increased tumor formation and metastasis and resistance to ...

Researchers From Rockefeller University Develop Novel Method To Fight Cancer

...th influenza. These cells weretriggered to undergo apoptosis (pronounced a-puh-TOE-sis), a type of cellsuicide or programmed death. The dying cells were cultured with dendritic cells,making the dendritic cells capable of activating killer T cells thatspecifically target influenza antigen. "In other words, the ...

Insights Into The Proteasome - A Fascinating Macromolecular Machine For Protein Degradation

... numerous biological processes such as cell cycle, apoptosis or the immune response. A research team at the Max Planck Institute of Biochemistry in Martinsried/Germany, headed by Wolfgang Baumeister, since several years one of the leading groups in the proteasome field, has published a review-ar...

Cancer Cells Self-Destruct When "Sweet Tooth" Is Thwarted

...pping gene, Bcl2, that preventscells from entering apoptosis too easily," Dang says. "If this gene is active in the cancercell, the cell is lesssensitive to glucose deprivation." One of the biggest obstacles to using a sugar-starvation treatment incancer patients, according to Dang, is that central n...

Green Tea Ingredient Can Kill Cancer Cells

...en tea, can kill a variety of cancer cells through apoptosis without affecting the normal cells," said Hasan Mu...paring of normal cells is very interesting because apoptosis is a programmed cell death which is a normal process going on in the body all the time. It is a pref...

Scientists Find New Trigger For Nerve Cell Death

... To determine whether potassium loss triggers apoptosis or is simply aside effect, Yu blocked potassium channels with a compound called TEA(tetraethylammonium). The potassium channel blocker reduced the number of cellsthat died after serum withdrawal, suggesting that potassium loss is indeed atrigger for ...

Two-Pronged Attack On Immune System Cells Engineered By HIV Gene vpr: Effects Markedly Reversed By Antisteroid Compound RU-486

...defend against the infection, Vpr actively induces apoptosis inneighboring immune system cells that have not ye...athology and laboratory medicine. "It alsoprevents apoptosis in the cells it infects, so those cells can stay alive tomake more virus. And then it kills the unin...

Plant-Based Therapies Examined For Colon Cancer Prevention

...ine of cell division andapoptosis goes awry. When apoptosis is disabled, tissues that rely on it nolonger have a way to regulate their cell populations and cancer may ensue. In the study, Shiff and fellow researchers will examine the influence ofadministering different amounts of either curcumin, ru...

Jefferson Scientists Find Potential Deadly Effects Of Two Missing Cancer-Suppressor Genes

... observation is that they are undergoing global apoptosis independent of p53," he noted. "Many studies suggest that cells that decide to undergo apoptosis do it in a p53 dependent pathway. That presents two intriguing questions: what is this p53 ind...

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