Tag: "apparently" at biology news

Knocking out SHIP gene improves success of allogeneic bone marrow transplants in mice

... missing or knocked out, the mouse's immune system apparently fails to recognize the donor's bone marrow as a foreign substance and allows the graft to survive. "If the SHIP gene plays a similar role in humans, then drugs to temporarily block SHIP could be given to a patient before they undergo an allogeneic bo...

Gene duplication adapts to changing environment

...g did not depend on the new gene, but the new gene apparently improved the efficiency," he concludes. As for the evolutionary forces involved in adaptation to a changing environment, scientists have debated whether positive selection for a new function is more important than relaxation of the selective pressure...

Insulin in heart development

...art is of normal structure but is reduced in size, apparently because the cells themselves remain small. Indeed, CIRKO cardiomyocytes appear immature in several other respects, particularly their preferential use of glucose, rather than fatty acids, as a metabolic fuel and their continued high expression of the...

Protein mix-up tied to suppressed immune response early in HIV infection

...cess in some HIV-infected individuals, CD8 T cells apparently become unresponsive to HIV surface molecules, essentially not attacking them, well before any profound loss of CD4 Helper cells. "It's like having many soldiers ready to fight for you, but the soldiers are so weak they cannot fight. They are not do...

UNC neuroscience center awarded $1.7 million for nerve growth and regeneration studies

...iator in the growth factor signaling pathways that apparently makes axons rapidly grow longer and also makes them wider. "We and others have the idea that growth factors are going to be a very important part of axon regeneration," Snider said. "It's our hypothesis that these growth factors actually set up the ...

Cell interactions in spermatocyte apoptosis

... toxicity is required for the response. Germ cells apparently die prior to meiosis, since the Fas ligand protein is induced specifically in diploid and tetraploid cells but is not found at heightened levels in the surviving population of haploid spermatids, and the latter cells do not show nuclear condensation ...

Mating molds provide new insights into speciation and human reproduction

...ty of Sad-1 to breach interspecies sexual barriers apparently works by preventing meiotic silencing from occurring, according to Metzenberg. "To our knowledge, this is the first case where the barrier between interspecies crosses has been observed to break down as a result of mutation in a single gene," Shiu ad...

A novel cardiac glycogen storage disease

...otein kinase. Like its yeast homolog, Snf4, PRKAG2 apparently regulates glucose metabolism by associating with AMPK's catalytic subunits. By introducing the human disease mutations into Snf4, the authors show here that the changes render the regulatory subunit constitutively active, causing it to bind to a cata...

Hypoxic mucus favors Pseudomonas infections in cystic fibrosis

...gen level is not sufficient to prevent its growth, apparently because the ASL contains nitrates or other electron acceptors that can substitute for molecular oxygen. However, hypoxia induces a stress response in the bacteria, promoting a mucoid phenotype. As has been seen in other bacterial species, this transi...

Perception is stored in single neurones

...atures. The Tbingen group concludes that there are apparently single neurones that sharpen our perception when they are trained to respond to categories. By making generalizations our brain is able to encode and interpret what we see around us....

Scientists at The Scripps Research Institute show most people with the genetic mutation for an iron-storage disease stay healthy

...blood iron levels." Having the gene mutation alone apparently is not enough to trigger the disease process. "The low rate of iron-overload disease among people who have the genetic defect suggests that other stimuli are involved, which is common in other genetic diseases as well," says Griffin Rodgers, M.D., D...

In harshest environments, some proteins protected by 'alternate' folding mode

...m. "This novel way of achieving protein folding is apparently nature's ultimate strategy to protect proteins from being digested by proteases," said David Agard, PhD, senior author on the paper and a Howard Hughes Medical Investigator at UCSF. Agard is UCSF professor of biochemistry and biophysics. To measure h...

Hammering cancer cell survivin

...ent on survivin for their continued proliferation, apparently because this protein abolishes a normal cell-cycle checkpoint and prevents them from being driven toward apoptosis. Zaffaroni et al. now show that hammerhead ribozymes directed at the survivin mRNA have a similar, potentially beneficial effect. Such ...

URI oceanography models migration and foraging strategies of North Atlantic right whales

...er column regularly adjusted their swimming depth, apparently in response to changes in the depth of the densest parts of the layer. Vertical adjustments of as little as 20 centimeters could increase the whales energy intake by as much as 20% above that predicted if the animal simply swam at a constant depth. ...

Iron supplements help African children learn to walk and talk

...berg School of Public Health. "Nearly one third of apparently healthy toddlers in this community were severely anemic. Before intervention, children with severe anemia showed distinct delays in both gross motor and language milestones for their age, and daily oral iron syrup helped to correct those deficits." ...

Aquaporins - the perfect water filters of the cell

...ger molecules is prevented. The main problem, that apparently has been solved by evolution, is: How can also the permeation of smaller ions be blocked? In particular, prevention of proton (hydrogen ion) permeation is of crucial importance since a difference in proton concentration (pH) between the cell interior...

Like storm clouds, natural disasters carry a silver lining, biologist says

...w storms, volcanoes, earthquakes, floods and other apparently catastrophic events renew life and boost diversity in ecosystems throughout the world, making them better for people and other species. Optimists claim that every cloud has a silver lining, said Dr. Seth R. Reice, an associate professor of biology s...

Columbia team finds treatment that corrects cellular defect at the root of heart failure

...ss phosphorylation. Giving the heart muscle a rest apparently helped restore normal function. "It's really an incredible opportunity to measure in humans at the molecular level the effect of treating heart failure," says Dr. Marks. "There's no other way to do that." Dr. Marks and his colleagues also removed ind...

A little larceny comes naturally to Northwestern crows

...ndian stories and legends. Those characterizations apparently are right on the mark, according to a pair of University of Washington researchers who have found a species of crow that is constantly looking for opportunities to steal food from other members of its flock. In fact, the behavior is so prevalent amo...

UNC, Duke researchers discover cause of mysterious pancreatitis in some people

...ations in which the same gene may be involved with apparently different disorders, depending on genetic or environmental interactions. We now know of at least two disorders, other than cystic fibrosis that are caused by mutations in the CF gene, the scientist said. In addition to this example of chronic nonalco...

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