Tag: "arthritis" at biology news

Schepens Eye Research Institute receives 'Roadmap' grant to develop center for curing eye diseases

...ing diseases as diverse as Alzheimer's, rheumatoid arthritis and heart disease to be part of a "think tank" to cure blindness. As the population ages, the need for new treatments for vision-robbing diseases is becoming critical. Age-related macular degeneration affects more than 1.75 million individuals in the...

The impact of genetic variations on the treatment of early rheumatoid arthritis

...n the connective tissues of the joints, rheumatoid arthritis (RA) can be a painful, crippling autoimmune disease. Traditionally, patients have been treated with disease-modifying antirheumatic drugs, or DMARDs, such as methotrexate (MTX). Several new therapies, however, focus on blocking tumor necrosis factor...

Identifying tick genes could halt disease, bioterrorism threat

...paralysis. Some of the symptoms can become chronic arthritis and neurological syndromes. In 2002 the Centers for Disease Control and Prevention recorded approximately 24,000 cases of the often-misdiagnosed and under-diagnosed illness. This was a 40 percent increase over the previous year. A number of ticks in ...

Probing the surface of white blood cells to enhance immune system medicine

...r autoimmune diseases such as diabetes, rheumatoid arthritis and lupus, as well as AIDS and cancer metastasis. The researchers, led by Henry N. Higgs, assistant professor of biochemistry at Dartmouth Medical School used scanning electron microscopy to analyze the finger-like projections coating white blood c...

OHSU-VAMC study sheds light on estrogen's benefit for MS

...fighting MS and other autoimmune diseases, such as arthritis and diabetes. The study, published in the "Cutting Edge" section of the current issue of The Journal of Immunology, shows the hormone augments a compartment containing T cells known as CD4+CD25+, and a regulatory protein called FoxP3. The cells are i...

New model can aid in understanding immune system diseases

... people with immune system diseases such as lupus, arthritis and multiple sclerosis. The study results appear in the August issue of the journal Immunity. The advance builds on previous UI studies done in cell culture and provides researchers with a model that allows them to see biological functions related to...

JCI table of contents, 16 August, 2004

...and IL-10 to T cellmediated spontaneous autoimmune arthritis in mice AUTHOR CONTACT: Shimon Sakaguchi Kyoto U...ptive immunity and cytokine networks in rheumatoid arthritis AUTHOR CONTACT: Gary S. Firestein University of California San Diego School of Medicine, 9500 Gilm...

Scientists build on case connecting inflammatory disease and depression

...disease and autoimmune diseases such as rheumatoid arthritis and inflammatory bowels. These mood disorders usually are attributed to psychological problems encountered by patients having to deal with the suffering and disability brought about by their diseases. However, Dantzer and Kelley explained, research ...

Protective mechanism exploited by tumors may provide new cancer treatment

...me; otherwise, you get autoimmune diseases such as arthritis and lupus," Dr. Munn says. "It's the difference between a car that is sitting there not moving but doesn't have on the emergency brake so it could move versus one that has on the emergency brake and can't move until you take it off. Natural tolerance...

Vioxx in high doses causes hypertension

... is growing: chronic, high-dose consumption of the arthritis pain reliever Vioxx can raise blood pressure and the risk of serious heart problems. Yet a "substantial number" of patients continue to be prescribed high doses of the drug, according to researchers at Vanderbilt University Medical Center. The resear...

Genetic mutation found that is major contributor to type 1 diabetes

...e diseases as well such as lupus, thyroid disease, arthritis and multiple sclerosis. SUMO-4 is the fourth gene identified that contributes to type 1 diabetes, taking a place just behind HLA, another regulator of immunity, in terms of relative risk. "Many genes are involved in type 1 diabetes, but this is one ...

Scientists discover genetic marker responsible for two-fold increase in risk of rheumatoid arthritis

...tic variation that doubles the risk for rheumatoid arthritis (RA). The variation, referred to as a single nucle...in about 28 percent of individuals with rheumatoid arthritis and 17 percent of the general population. This discovery resulted from a collaboration between scien...

Tips from the journals of the American Society for Microbiology

...w pathogen isolated from a patient with rheumatoid arthritis in Japan. Journal of Clinical Microbiology , 42. 6: 2366-2371.) ...

The UV advantage

...clerosis, Type I diabetes mellitus, and rheumatoid arthritis Enhanced mental health and lessening symptoms of seasonal affective disorder, premenstrual syndrome, and depression "The literature is clear. Adequate amounts of vitamin D cannot be achieved by at the current low levels set years ago by the Instit...

New research suggests therapeutic approach for autoimmune diseases

...dea, Dr. Roopenian used mice that normally develop arthritis caused by autoantibodies. His team shows that the elimination or blocking of FcRn resulted in the reduction of autoantibodies and a corresponding protection from arthritis. "These findings suggest FcRn is a potential therapeutic target for many forms...

Animal studies show promise treating severe chronic pain

... nearby veterinary hospitals with severe pain from arthritis and cancer. "We were very encouraged to see a long-term therapeutic benefit that did not diminish with the progression of the disease," said Iadarola. "When a cancer progresses, you often have to increase the dose of conventional pain medications, ...

Brace therapy for osteoarthrisis, legal issues in TBI research, prosthetic fitting

...liner products. Nearly 80% of people with knee arthritis satisfied with brace treatment, pg 187 In a stu.... Understanding brace use among patients with knee arthritis may guide future treatment options. Easy Strutter Functional Orthosis System outperforms axilla...

Protein may help prevent autoimmune attacks

...ausing autoimmune conditions like diabetes, lupus, arthritis and multiple sclerosis. "This protein may be one of the components that goes awry when the immune system's normal inflammatory processes malfunction, leading some T cells to attack the body," says Scott Lovitch, an M.D./Ph.D. student at Washington Un...

A multi-institutional study may offer clues for the treatment of some autoimmune diseases

...rs such as T-cell leukemias. Psoriasis, rheumatoid arthritis and Crohn's disease are also thought to benefit from a PNP inhibitor. PNP Inhibitors and BCX-1777 BCX-1777, (1S)-1,4-dideoxy-1-C-( 4-hydroxypyrrolo[3,2-d] pyrimidin-7-yl)-1,4-imino-D-ribitol hydrochloride [1:1] is a transition state inhibitor of ...

Discovery could improve anemia treatment in patients

... including infections, inflammatory bowel disease, arthritis and cancer, commonly become anemic. The anemia can make them sicker, is sometimes severe enough to require a blood transfusion, and responds only partially to current treatments. Researchers at Children's Hospital Boston, Harvard Medical School, and ...

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