A new hypothesis about autoimmunity. Is it possible to be too clean?
...seases like Type 1 diabetes, lupus, and rheumatoid arthritis have low T cell numbers. If the body detects low levels of T cells, it resorts to homeostatic expansion, a mechanism that has never been associated with autoimmunity before. Under homeostatic expansion, growth signals stimulate the existing T cells i...JCI table of contents, 15 March 2004
...oid Arthritis Unexpectedly Detrimental Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting a...nvolvement in this disorder. TITLE: Experimental arthritis in CC chemokine receptor 2null mice closely mimics severe human rheumatoid arthritis AUTHOR CONTACT:...Inhibition of Borrelia burgdorferi protein may reduce Lyme disease transmission
...humans. Lyme disease was first named in 1977, when arthritis was observed in a cluster of children in Lyme, Connecticut. The bacterium Borrelia burgdorferi is transmitted to humans by the bite of infected deer ticks and in 2002 caused more than 23,000 infections in the United States, mostly localized to Califo...JCI Table of Contents, January 15 2004
...humans. Lyme disease was first named in 1977, when arthritis was observed in a cluster of children in Lyme, Connecticut. The bacterium Borrelia burgdorferi is transmitted to humans by the bite of infected deer ticks and in 2002 caused more than 23,000 infections in the United States, mostly localized to Califo...New roles for protein modifications in cell migration
... including blood coagulation disorders, rheumatoid arthritis and asthma. These proteins act to proteolytically release membrane-bound growth factors or to disrupt components of extracellular matrices such as collagen and proteoglycans (which help to build skin and soft tissue), and their roles in development a...Researchers pinpoint enzyme involved in arthritis onset
...y, could aid in the discovery of novel targets for arthritis drugs. The researchers found that inhibiting the e... progression of arthritis, since the simulation of arthritis was prevented by inhibiting PKR. Arthritis is a common problem worldwide. Both osteoarthritis and rh...JCI Table of Contents, November 3, 2003
Gene therapy establishes a TRAIL to arthritis treatment In the November 3 issue of the Journal ... successfully limits the incidence and severity of arthritis in a mouse model of collagen-induced arthritis and joint inflammation. The regime represents a thera...FDA approves Raptiva (efalizumab) for chronic moderate-to-severe plaque psoriasis
... antibody for psoriasis (FDA approval), psoriatic arthritis (Phase II) and other indications; and with Millennium Pharmaceuticals, Inc. on a recombinant protein, CAB-2 for vascular inflammation (preclinical). Earlier-stage development programs focus on antibodies and other compounds developed by XOMA for the ...Researchers show autoantibodies occur before lupus in New England Journal of Medicine
...tient," said John Harley, M.D., Ph.D., head of the arthritis and immunology research program at OMRF and senior author of the study. Harley also serves as chief of rheumatology at OUHSC and staff physician with the Veterans Affairs Medical Center in Oklahoma City. "For the first time, this study shows that aut...Novel proteins designed that block inflammation regulator associated with rheumatoid arthritis
...te inflammatory responses implicated in rheumatoid arthritis and several other autoimmune diseases," said Dr. T...sis and systemic lupus erythematosis." Rheumatoid arthritis is an autoimmune disease in which the body's immune system attacks its own tissues, mistaking them f...Researchers solve the mystery of a key structure in immune system cells
...e system mistakenly attacks its own tissues, as in arthritis or multiple sclerosis, and conversely, thwart those in which the body fails to eradicate or even notice an attacker, such as some tumors. "The other thing that's important about this paper," adds Dr. Davis, "is that -- almost for the first time -- i...Novel therapeutic target identified in fight against Rheumatoid Arthritis
...ese mice were treated with a protocol that induces arthritis in normal mice, the 'low-synoviolin' mice were protected from the arthritis. This result firmly identified synoviolin as a key player in RA pathology. The scientists went on uncover the cellular mechanism by which altered levels of synoviolin could ...JCI Table of Contents, September 15, 2003
...15483.pdf CD69 and TGF-beta: double trouble in arthritis Francisco Snchez-Madrid and colleagues from Hospi...cytokine CD69 in a mouse model of collagen-induced arthritis (CIA). Their results strongly suggest that CD69 is a negative regulator of autoimmune reactivity and...Drug developed for rare disease may help millions more as treatment for cancer, autoimmune diseases
...atments for autoimmune diseases such as rheumatoid arthritis and Crohn's disease. But this therapy requires regular injections of the antibodies. The next question on Brewer's plate is whether TM can do the job even easier. "We have an oral pill that's shown to inhibit TNF-alpha in mice. The concept is that fo...UCF brain cell research spawns hope for longer life
...rders -- such as Alzheimer's disease -- as well as arthritis and other joint-related problems, Rzigalinski says. Most recently, the Rzigalinski lab has found that the nanoparticles have potent anti-inflammatory properties. The investigators plan to explore the possibility of creating a coating from the partic...Psoriasis treatment based on Weizmann Institute Research passes phase II clinical trials
...partment, the condition of psoriasis and psoriatic arthritis patients was greatly improved. The treatment had n...ed Remicade ®) for the treatment of rheumatoid arthritis as well as for the treatment of the inflammatory bowel diseases, Crohn's disease and colitis....Lipids get the spotlight in new NIGMS 'Glue Grant'
...ject that promises to shed light on heart disease, arthritis and other major illnesses. The five-year grant will fund the Lipid MAPS Consortium, a large collaborative effort led by the University of California, San Diego. NIH anticipates total funding of about $35 million on the project. The new award is a "...Medimmune and Critical Therapeutics to co-develop treatments for severe inflammatory diseases
...ange of inflammatory illnesses, such as rheumatoid arthritis and sepsis. The companies plan to focus on developing drug products with the potential to block HMGB-1, which if successful, could help reduce the injury and death associ-ated with severe inflammatory diseases and infections. "CTI's proprietary a...... plays a key role in the development of rheumatoid arthritis Rheumatoid arthritis is a chronic inflammatory disease characterized by joint destruction. It has been suggested that the......fections, and autoimmune disorders like rheumatoid arthritis and multiple sclerosis....