Tag: "arthritis" at biology news

Gene therapy promising for rheumatoid arthritis

...okine gene therapy to treat and prevent rheumatoid arthritis in an animal model. Arthritis researchers James M. Woods, M.D., research assistant professor of medicine, and Alisa Koch, M.D., professor of medicine, Northwestern University Medical School, described the new gene therapy in an article in the Feb. 1...

'Flap' on protein suggests new therapies for autoimmune diseases

...licated in the development of lupus and rheumatoid arthritis have discovered a unique flap that is crucial to t...tant therapeutic applications in lupus, rheumatoid arthritis and other autoimmune diseases. Tall-1 is an important regulator of the immune system. It spurs B ce...

Findings link disease specific anitbodies to activation of T cells for the first time

...and other autoimmune diseases including rheumatoid arthritis and Lupus. Dr. Smith joined REI in 1999. He is a graduate of the University of Missouri School of Medicine, served his residency in medicine at the University of Illinois, Chicago and completed fellowships in biochemistry and molecular biophysics ...

Scientists at The Scripps Research Institute show most people with the genetic mutation for an iron-storage disease stay healthy

...were based upon the occurrence of symptoms such as arthritis and diabetes that are also common in the normal population. An actual study of a large normal population had not previously been carried out. The study that Beutler led compared symptoms in homozygotes with the same symptoms in patients who had not i...

ENBREL is first therapy approved for psoriatic arthritis

...pproval to reduce the signs and symptoms of active arthritis in patients with psoriatic arthritis. ENBREL can ...spond adequately to methotrexate alone. Psoriatic arthritis is an often painful chronic inflammatory disease characterized by both joint and skin manifestations...

Scientists identify key risk factor for canine arthritis: Method may eventually give humans similar warning

...socket correlates strongly with the advent of hip arthritis later in a dogs life. "The relationship between hip laxity and arthritis in dogs is akin to the relationship between high cholesterol and heart disease in humans," said lead...

Enzyme mimetic reduces tissue damage in colitis animal study

...rom another MetaPhore study looking at rheumatoid arthritis published this month in Arthritis & Rheumatism. In that study, an SOD mimetic was highly effective, not only at treating inflammation, but also preventing joint damage and reducing elevated cytokine levels to near normal in animal models of arthriti...

New Phase 2 study shows ankylosing spondylitis patients respond to ENBREL (etanercept)

... Ankylosing spondylitis is a chronic inflammatory arthritis characterized by joint stiffness, pain and extra b...ly active polyarticular-course juvenile rheumatoid arthritis in patients who have had an inadequate response to DMARDs. In June 2000, the FDA approved ENBREL for...

Phase 3 psoriatic arthritis data for ENBREL (etanercept) announced at a national scientific meeting

...roduct to be considered for treatment of psoriatic arthritis SAN FRANCISCO, November 11, 2001 Phase 3 resu...EL (etanercept) studied in patients with psoriatic arthritis will be presented this week at the 65th Annual American College of Rheumatology National Scientific ...

Queens University chemist wins U.S. award for new reactions to make drugs, agrochemicals, conductors

...nieckus method to prepare celecoxib (Celebrex), an arthritis painkiller less likely than others to cause serious stomach problems. The chemists research team has also discovered a means to protect wheat crops against a destructive fungus, called Take-all. When asked why he became a chemist, Snieckus described ...

Harnessing the autoimmune response

...block or delay the onset of experimentally induced arthritis a disease process that is driven by high levels of TNF-a. This robust immune response, as compared with that seen in control vaccinations with unconjugated TNF-a peptides, seems to reflect relatively late events in the activation of self-specific B ...

Blood vessels found to signal chain of destruction in bone diseases

...he National Institutes of Health. Such popular arthritis drugs as Vioxx, Celebrex, and Enbrel work on the principal of interrupting the work of the cytokines to ease inflammation. Vioxx and Celebrex interrupt a similar cascade of events by preventing IL-1 from generating prostaglandins at inflammatory sit...

Aspirin targets key cell that triggers organ rejection and other immune responses, report University of Pittsburgh researchers in journal article

...tients with various autoimmune diseases, including arthritis and rheumatic fever, says lead author Holger Hackstein, M.D., a visiting research fellow at the University of Pittsburgh's Thomas E. Starzl Transplantation Institute, who is working in the lab of Angus Thomson, Ph.D., D.Sc., professor of surgery and ...

Gene therapy for arthritis

... apply this principle to suppress collagen-induced arthritis (CIA), a mouse model of rheumatoidarthritis. Nakajima and colleagues previously used adoptive transfer of transgenic T cells to block autoimmuneresponses in the CNS, and here they employ a similar strategy, transducing collagen-specific helper T cell...

Leptospirosis raising health concern among companion animal owners

...ffness. Pet owners may mistake this early stage as arthritis and treat the dog with aspirin or another nonsteroidal anti-inflammatory drug. A less frequent symptom seen in dogs is excessive thirst and urination. Harkin said pet owners are at risk because the dog drinks and urinates so much that they may do so ...

Decorin as a conduit for Lyme disease bacteria

...hroughout the body and infect various organs. Lyme arthritis occurs when the pathogens colonize the joints, and Brown and colleagues have now identified a molecular interaction between host and pathogen that seems to be particularly important for this aspect of the disease. Borrelia burgdorferi spirochetes int...

Popular pain analgesics found to affect central nervous system: Study identifies both peripheral and CNS mechanisms of action of NSAID use

...n."The findings indicate new treatment options for arthritis and other inflammatory pain conditions," said Cheryl A. Kitt, Ph.D., program director for pain research at the NINDS. "Targeting the central nervous system when using NSAIDs, rather than the specific peripheral pain site, may result in more effective...

A paradox helps explain how aspirin works

...e blood stream, a process implicated in rheumatoid arthritis and heart disease, suppressing IL-4 with aspirin may be one reason the drug protects against both conditions....

Amazing light emission properties of gold lead to many applications

...arly gold with sulfur, made people with rheumatoid arthritis feel better," Fackler says. "That led to major eff...says. The healing properties of gold in rheumatoid arthritis patients may be due to the way gold interacts with a substance called peroxynitrite, a poison probab...

New drug blocks rheumatoid arthritis early on, with few side effects

...lly slows or even stops the progress of rheumatoid arthritis (RA) at the earliest stages of the disease, helpin...revent joint damage in the first place. Rheumatoid arthritis is marked by an immune system attack on joints both on bone and on the cartilage that surrounds the...

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