Gene clusters predict atherosclerosis severity, susceptibility
...ividualized approaches to identifying and treating atherosclerosis that are tailored to and informed by a patient's u...ease susceptibility, the researchers said, because atherosclerosis tends to progress toward the heart. Once the samples were mapped by defined segments, the res...JCI table of contents September 15, 2004
...t their roles in the initiation and development of atherosclerosis remain ill-defined. To investigate the role of eac...examine the effect of loss of PGI or TXA action on atherosclerosis development. Relative to apoE/ mice, the apoE/IP/ mice had accelerated initiation and development of...Picking prostanoids to provide protection
...t their roles in the initiation and development of atherosclerosis remain ill-defined. To investigate the role of eac...examine the effect of loss of PGI or TXA action on atherosclerosis development. Relative to apoE/ mice, the apoE/IP/ mice had accelerated initiation and development of...Probing the surface of white blood cells to enhance immune system medicine
...erol in coronary arteries, drugs could prevent the atherosclerosis that leads to heart attacks. Higgs extended this work to compare lymphocytes in patients with Wiskott-Aldrich syndrome, a hereditary immune disorder that affects males and manifests itself through low platelets and recurrent bacterial infections. The...JCI table of contents, 2 August, 2004
... the adaptive and natural immune responses against atherosclerosis and thus provides potential new means to enhance a...fic for epitopes of oxidized LDL and protects from atherosclerosis AUTHOR CONTACTS: Christoph J. Binder or Joseph L. Witztum University of California, San Diego, 9500...UNC researchers awarded $8.65 million from National Institute on Aging
...mal studies, IGF-1 is known to play a role both in atherosclerosis and aging. Also key to the research funded by the grant are two School of Medicine laboratories. Dr. Susan Smyth, assistant professor of cardiology, directs a comprehensive, state-of-the-art cardiovascular phenotyping laboratory that examine...Lupus Research Institute awards $3 million in novel research grants to further new science in lupus
...een circulating endothelial cells and the onset of atherosclerosis in lupus. These cells are activated by immune stimuli and are potential participants in the inflammatory process that contributes to tissue damage and atherosclerosis. Using a large patient base, Dr. Clancy's study will test this intriguing idea wh......mption could also contribute to the development of atherosclerosis and cardiovascular disease. According to co-author Dr. Peter Havel, a research endocrinologist at the University of California, Davis, "Although this short-term experiment provides important new data, additional research is needed to investigate t...Moderate alcohol consumption increases plasma levels of a protective hormone
...HEAS is believed to play a protective role against atherosclerosis in both genders," said Henk F.J. Hendriks, a senior scientist at TNO Nutrition and Food Research in The Netherlands and corresponding author for the study, "just like low testosterone does for men." Atherosclerosis is characterized by irregularly di...Could vitamins raise levels of bad cholesterol? Animal study suggests they might
...n some animal studies to protect the arteries from atherosclerosis and the pancreas and other organs from damage caused by diabetes. "In other words, oxidant stress is damaging in some contexts, but probably beneficial in others," he says. "In terms of the risk of cardiovascular disease," he adds, "the previous vi...JCI table of contents, March 1 2004
...defective macrophage insulin signaling and promote atherosclerosis Individuals with diabetes show an increased susce... an important cause of both diabetes and increased atherosclerosis risk. In the March 1 issue of the Journal of Clinical Investigation, Chien-Ping Liang and colleagues...JCI table of contents, 16 February 2004
...smooth muscle cells, which have been implicated in atherosclerosis and heart disease. In the February 16 issue of the Journal of Clinical Investigation Richard Assoian and colleagues from the University of Pennsylvania delve further into this notion by elucidating the mechanism by which HDL and APOE inhibit this p...Gene may protect against heart disease rather than be harmful as previously thought
...e version of the locus would get two times as much atherosclerosis as the mice with the other version. The study's au...n. But, the version of A20 correlated with reduced atherosclerosis turns NFkB off less effectively. As a result, NFkB remains active longer and targets of NFkB, the ge...High heart risk for lupus patients linked to death of cells lining blood vessels
...al cell damage, and understand its contribution to atherosclerosis and clot formation, to help patients and develop t...endothelial cell test predicts actual incidence of atherosclerosis and other heart and vascular diseases in lupus patients and others, and whether it could be combined...Scripps scientists link ozone to atherosclerosis
...ified products are critical to the pathogenesis of atherosclerosis because they are toxic to white blood cells, smoot... is a substantial fraction of patients who develop atherosclerosis without displaying these risk factors. Sensitive diagnostic markers that would allow early identific...JCI Table of Contents, November 3, 2003
...************** TGF-beta keeps T cells in check in atherosclerosis TGF-beta inhibits atherosclerosis by dampening T cell activation, which suggests that inhibition of T cell activation may represent a ...Cellular fat sensor slows heart disease
...athway that significantly curbs the development of atherosclerosis - the accumulation of fatty deposits on arterial w...end off invading agents, can go awry and encourage atherosclerosis and heart disease." The researchers found that the PPAR-delta switch cut heart disease in half. It d...JCI table of contents, 15 October, 2003
...on of the transcription factor NF-kappaB increases atherosclerosis a chronic inflammatory disease that causes the pr...er time. An initiating event in the development of atherosclerosis is the accumulation within vessels of lipids such as low-density lipoprotein (LDL), which acts as a ...COX-2 inhibitors and renal damage in obesity-related Type II diabetes
...the development of Type II diabetes, hypertension, atherosclerosis and chronic renal disease, most of which are interdependent factors. Diabetic nephropathy, a kidney disease that develops in as many as 20 to 40 percent of diabetics, is the leading cause of end stage renal disease (ESRD). In addition to diabetes, ob......sults are consistent with the current concept that atherosclerosis is an inflammatory process, and suggests that the Fisher 344/Brown Norway F1 hybrid rat (F344xBNrats) may be a good model for studying the vascular changes that occur early in the development of atherosclerosis. The authors of a new study entitled...