Millennium Clones Diet-Induced Obesity Gene
...sue the development of a small molecule that could attach to a receptor andaffect the protein's function. If successful, the small molecule could becomethe basis of a drug for obesity," said Robert Tepper, M.D., chief scientificofficer, pharmaceutical division of Millennium. Human obesity, being more tha...Heat-Shock Vaccine Stops Bacteria Dead
...d approach: when designing improved vaccines, they attach vaccine molecules to "carrier" proteins that stimulate T cells and enlist themin the antibody production process. However, until now these carrier proteinshave had a major drawback: in most cases, they came from diphtheria and tetanusbacteria and, as...UI Laboratory Develops Procedure To Study DNA Replication
...art in an extract from human cells. Theresearchers attach magnetic beads to the DNA molecules and use a magnet toisolate the molecules and associated replication proteins. The researchers canthen manipulate the extracted DNA and add specific replication proteins in acontrolled manner to understand the mecha...New Study By TSRI Scientists Sheds Light On Viral Clearance In Acute Hepatitis B Infection
...that are secreted by cells of the immune system -- attach to receptorson infected cells and trigger them to purge themselves of the virus. Thissignificant decrease in viral load reduces the number of cells that must bekilled, thereby preserving the function of the organ while the virus is removed. The scie...Sandia, University Of Montana Researchers Try Training Bees To Find Buried Landmines
...es can be trained toseek TNT, the Montana team may attach small diodes onto thebacks of several hundred TNT-trained bees. Then, using ahandheld radar tracking device, they will chart where thosebees go to determine whether they tend to forage near thelocations of known landmines. Countering the worst form o...Researchers Track Path Of Safer Gene Delivery Method
...ase. They found that the PEI/DNA complexes attach to cell membranes and thenjoin into clumps that are taken into the cell. Once inside the cell, rather thanbeing broken down and used by the cell's machinery, the complexes move into thenucleus, where the desired gene is turned on. The researc...Slimy Bacteria Common Cause Of Chronic Infections
...liar tofollowers of the CBE. It tells how bacteria attach to surfaces and, when there'sa quorum of cells, form biofilms. It explains the communication that goes onbetween cells as they create microscopic communities complete with canals,towers and even balloons. It describes how bacteria know when to come t...Stanford launches interdisciplinary initiative in the biological sciences
...ion with Spudich.The biochemist showed Chu ways to attach tiny micron spheres to strands of DNA,which allowed Chu to use optical tweezers to become the first person to studythe physical properties of individual polymer strands. In return, Chu's studentstaught Spudich's students how to build and operate atom...New study establishes when pregnancy starts
...regnancy starts in humans. Fertilized eggs attach themselves to the lining of the womb six to 12days after ovulation, the research shows. In most successful pregnancies, thatimplantation - the real start of pregnancy -- occurs on day eight, nine or 10following ovulation. Day eight appears to be the ...Jefferson scientists further develop gene repair technique
...amounts of RNA, that has thecapability to find and attach itself to a certain part of a gene. The smallgenetic vehicle is designed to trigger the cell's normal DNA repair system intoaction as well. The repair mechanism scans the DNA looking for any mismatches ortwo strands of DNA that don't seem in sync. Wh...Threatened marbled murrelet first to be hatched in captivity
...ys Cooke. He hasn't decided yet whether to attach a radio transmitter to the bird."We're debating th...o maximizeits chances of survival. But if we don't attach a radio, then we'll never knowwhat happened to it."...H.pylori bacteria and their human hosts
...altransmission, some penetrate the mucus layer and attach to epithelial cells. These bacteria release molecules that irritate and degrade epithelial cells,which creates food for the bacterial colony. "Our most surprising discovery is the key role played by this small group ofadherent bacteria," Kirschner sa...Stanford scientists use noise to sort proteins
...ddition, theresearchers are working on new ways to attach membranes that they hope willallow them to study another important class of molecules, called integratedmembrane proteins. "This system combines interesting physics and engineering to produce a devicethat may prove useful for biology," says Boxer, "a...Pinpoint targeting promises improved success in gene therapy for blood and other disorders
...r cells butnot into other healthy cells, one could attach the poison gene to specificpromoters -- or pieces of DNA - that function only in cancer cells and not inothers." A report on the study appears in the Aug. 17 issue of the Proceedings ofthe National Academy of Sciences. Besides White, authors ...Scientists suggest genetic shutdown links estrogen, heart disease
...ver a bar code so it can't be read; smallmolecules attach to a gene's "on switch," a stretch of DNA called the promoterregion, and shut the gene down. But in clogged heart blood vessels, the researchers found almost threetimes more methylated ER genes -- around 11 percent. "We've been loo...USGS scientists tracking environmental damage from Floyd
...of research to see if that compound, which usually attach tosediments, was stirred by Floyd's heavy rains in New York. These efforts arefunded in cooperation with the New York State Department of EnvironmentalConservation USGS scientists are also collecting samples from New York City's West-of-Hudsonwater-s...New treatment may relieve chronic pain, as reported in the 19 November issue of Science
...leagues believe that it should also be possible to attach other molecules to substance P that would quiet--but not kill--the neurons after sneaking inside. One possible candidate might be a molecule known to temporarily shut down the neurons' powerhouses, the mitochondria. The team's findings also provide r...Key progress by Weizmann scientists in the race to unravel ribosomal structure
...iggers protein biosynthesis. "The messenger has to attach itself to a specificsite in order to open the gate to protein production, which is essentially kept under lock and key,"explains Yonath. Once activated and bound, it was time to record the 30S subunit "in the act" - a feataccomplished by flash freezi...'Frozen pictures' allow far-reaching glimpse into the cells protein factory
...entially kept under lock and key. "The mRNA has to attach itself to a specific site in order to open the gate to protein production," explains Yonath. Once activated and bound it was time to record the 30S subunit "in the act" - a feat accomplished by flash freezing the crystals through sudden exposure to c...Team led by MSU biologist finds bacteria deep in Antarctic ice
...e crystals initially nucleate in the lakewater and attach to the overlying ice at a random orientation. Adams said the group hopes to get more core samples from the National Science Foundation,which paid for the research along with MSU. Other MSU scientists who helped with the project are Bob Brown, Cri...