Brown researchers use wildcards to develop better way to sequence DNA
... DNA probes. A perfect universal base would attach itself to all four bases in DNA. If the universal bases behave closely to ideal, this is by far a superior method, Preparata said. It would be a fundamental change in the way of doing sequencing. For this wo...UF scientists discover novel mechanism underlying bone destruction
...r therapies. When osteoclasts encounter bone, they attach themselves to it, forming a connection similar to a suction cup. Using tissues from mice and cows, UF researchers discovered that when the link takes place, microfilaments help move the enzyme V-ATPase from the core of the osteoclast to its surface. ...Study provides new details of 'the birth of a virus'
...chinery' that causes proteins called ubiquitins to attach to Gag," Gttlinger says. "This binding enables the 'buds' of virus to leave the cell membrane and spread to other cells. The fact that retroviruses can use this mechanism to escape the cell without destroying it may be a significant advantage to the......hat combines with phosphorus, then helps ubiquitin attach to the regulatory protein. Methods for blocking this process, and perhaps improving treatments for cancer and asthma, may result from Yaron's research....Scientists study life of economically important blue crab
...oat following each crab. The researchers will also attach small devices to a larger number of female crabs about 500 each year for the next three years to record information on water temperature, depth and salinity as the crabs make their spawning journey. They won't be able to analyze that information, h...... teams use short duration suction cup mountings to attach acoustic tags on the whales. The tags can collect several gigabytes of sound recordings and movement data. After a few hours the tags are retrieved, the data are downloaded into a computer, and within minutes the tag is ready to 'go on board' another...Mouse gene trap helps decipher brain's wiring diagram
...ool for finding a needle in a haystack. The trick: attach a molecular tag to the needle. Through the magic of genetic engineering, lines of mice are bred to express telltale mutations. Brain neurons harboring particular wiring molecules are revealed by a blue tint, while their tentacle-like extensions, or a......ince the discovery in 1987 that it was feasible to attach unnatural amino acids to proteins, scientists have wondered how that tantalizing possibility with its potential for engineering proteins with entirely new functions could be harnessed in an efficient, cost-effective manner. "Unnatural amino acid mut...University of Washington professor's new book seeks to rewrite understanding of cell biology
...rs have a high negative charge and water molecules attach in organized layers. But that matrix can be condensed by certain ions that bind the polymer strands together and force the water out. When the condensed vesicle opens a portal to the outside of the cell, a series of reactions ensues that causes th...Mistaken attachments cause cancer-promoting chromosome distribution errors
...ecause kinetochores, the areas of chromosomes that attach to the spindle, must satisfy conflicting requirements. Kinetochores must be big enough to ensure attachment to at least one side of the spindle, but small enough such that attachment to both sides of the spindle is unlikely. Sometimes this trade-off ...Proteins are vastly more complicated than previously realized
...x consisting of thousands of protein fibers that attach to cells at numerous points. These proteins connect with other proteins and hold the mass together a sort of super glue for cells. It is the movement of these fibers and the resulting pull and push on the cells attached to them, that transmits force...Key step in gene activation discovered
... Group" from the circulating cellular material and attach it to the Histone proteins in the core of a nucleo...structs a code that signals the SWI/SNF complex to attach to the Promoter and begin turning that gene on," says Ahmed H. Hassan, a member of the Workman team ...When Shewanella meets goethite: Evidence found of recognition between animate and inanimate objects
...cades, people have been interested in how microbes attach and release from mineral surfaces. The interaction...er modified an atomic force microscope so he could attach a living bacterial cell to an arm and move the cell toward a mineral surface to observe and measure ...E. coli bacteria may be more useful than you think
...s well as natural biological membranes. "If we can attach some kind of propeller to these reconstituted motors and devise a way to impose a 200 millivolt electrical potential across the membrane to drive one-way proton flow, we will have a controllable turbine," Manson claims. "In addition to direct applica...Vitamin deficiency may exacerbate motor neuron disease
...s a new research pathway for studying how proteins attach to one another and might also have clinical implications for people who have SMA, said Dreyfuss. “These SMN target proteins obtain their methyl groups from a methyl donor called, S-adensylmethionine, which itself depends on folate and vita...Homing in on better bone marrow transplants
...t the CD44 variant allowed cells to roll across or attach to a layer of tethered, E-selectin-containing cells, even as a jet of water was acting to displace the cells. The variant is made only by HPCs, and not by more mature blood cells. This restricted production of the variant should allow Sackstein to is...Researchers identify protein important for beginning gene-activation process
...plexes, or HATs. Gene activation begins when HATs attach to a single gene on a DNA molecule. Although many different proteins comprise SAGA and NuA4, they share just one protein, Tra1. With a mixture of experimental methodstraditional biochemical and genetic experiments as well as a "crosslinking" exp...Lithographic technique creates neuronal networks in a dish
...to the patterned polylysine where they selectively attach to the surface. "Within a few days, the cells send out processes that explore the environment, preferring areas that have intact polylysine," Wheeler said. "The cells soon mature and begin sending electrical signals."Microlithographic techniques als...Marine methane consumed by consortia of bacteria
...osarcinales, were tagged with flouresent dyes that attach only to individually specific genetic material. In this way, one dye attached to the Desulfosarcina and another, of a different color, attached to the Methanosarcinales. Investigation under flourescent light showed the sulfate-eaters surrounding th...Berkeley chemist wins national award for work with new polymers
...luble and toxic," said Frechet. "So what we do is attach them to a dendrimer." They then escape the bloodstream only in the vicinity of tumors, which transport them inside their cells. Once there, the dendrimer-drug link is designed to break down and the drug is released, he explained.His group has several...