Purdue researchers expose 'Docking Bay' for viral attack
...If we could modify the proteins in the baseplate's attachment fibers, it might enable T4 to destroy harmful bacteria. This research could be a step in that direction." Nanotechnology applications also are possible. "The baseplate of this virus is essentially a complex molecular machine," Rossmann said. "We have...Jaws of clamworm are hardened by zinc say UCSB scientists
...tudied the way that mussels attach to rocks. Their attachment threads are another example of the use of copper and zinc in nature. "Their biochemistry is very similar to both worms. It's only natural that I would get into the jaws." "A lot of science involved in exploring the relationship between metals and p...Newly invented Endometrial Function Test (EFT®) solves the puzzle of unexplained infertility
...difficult step in the process of conception is the attachment (implantation) of the embryo to the endometrium. Abnormalities in the process of implantation are believed to be the basis of many cases of unexplained infertility in women. A normal healthy endometrium will make many different substances (markers). ...Key regulatory enzyme is a molecular 'octopus'
...ind to the receptor and phosphorylate it, allowing attachment by beta arrestin, and at the same time, bind the G protein to switch it off. "This structural determination has significance at two levels," concluded Lefkowitz. "First, it gives us important new information about the basic biology of this important ...Double research boost for tissue engineering community
... industry to reproducibly and reliably measure the attachment of cells to biomaterial surfaces. The interaction of implanted devices with living tissue and individual cells is an important determinant in the success and safety of indwelling prosthetic devices. To this end, this systematic study will utilise h...Researchers discover structure of Nature's 'circuit breaker'
...to the "floppy" portions of the protein, to create attachment points for crystallization of the proteins. The first x-ray structures using the crystals revealed a startling surprise about the voltage-dependent potassium channel, said MacKinnon. Instead of being embedded deep within the protein, the voltage-sen...Purification of signaling protein may boost tissue engineering
...ow understand that this protein is modified by the attachment of a lipid after it is produced, which gives it a ...t protein family, mouse Wnt3a, is activated by the attachment of a lipid called palmitoyl to a particular amino acid on the protein. The lipid is necessary for ac...Researchers discover strategy that shields HIV from destruction
...s in the viral envelope that caused changes in the attachment of the glycan molecules. The discovery extends a picture of a virus that contains a "silent face" composed of masses of large glycan molecules that obscure its true nature to the immune system. However, in order for HIV-1 to engage CD4 cells, part o...Meanwhile, back to barnacles...
... this upon the hypothesis that interruption of the attachment of adhesin proteins which are secreted by many organisms to serve as glues would result in fewer organisms settling on these surfaces in the first place, and would promote organism release, i.e. not many would be able to stay attached long if they...U.S.-German research consortium sequences genome of versatile soil microbe
...MHH identified numerous chemosensory systems, cell attachment factors, and transport systems in P. putida that had been thought to be involved in virulence in P. aeruginosa. For example the KT2440 (P. putida) genome contains a chromosomal region that is present in 85% of P. aeruginosa clinical isolates from sep...Drug delivery leaps biotech hurdles
...ere they are needed in the body. These include the attachment of targeting molecules, such as monoclonal antibodies and receptor ligands, to carriers such as liposomes, polymer particles, and nanospheres. A number of labs are even learning how to use soccer-ball-shaped fullerene molecules or algae skeletons as ...New nanoparticle coating mimics dolphin skin
...tin or copper-based coatings, which reduce aquatic attachment but come at a price: copper and tin leach into the... correct -- do surface feature sizes influence the attachment of marine organisms?" If she's right, the implications could be straight out of science fiction: ma...Revealed: How a master protein remodels chromosomes to orchestrate gene expression
... longer, previously identified chromosomal "matrix attachment regions" (MARs), lengths of chromatin rich in the ..., up to many thousands of base-pairs away from the attachment site -- by providing docking sites for these remodeling complexes, which alter the distribution of n...New predictor of heart disease risk found
... Davis School of Medicine and Medical Center. "The attachment of white blood cells and their entry into the vessel wall are early events that lead to fatty streaks or early plaque formation." These novel findings at the molecular and cellular level support the work of other investigators who have shown that pat...Ulcer-causing bacteria use stomach inflammation to their advantage
...stigators at Washington University, identified the attachment protein used by the bacterim, calling it Lewis B antigen binding adhesin (BabA). That discovery also appeared in Science. The present study began with the intriguing observation that a mutant H. pylori strain engineered to lack BabA still adhered to...New technologies to battle little known, widespread cattle disease
...e have identified a bacterial protein, fibronectin attachment protein (FAP), on Mpt that apparently facilitates the ability of the bacteria to attach itself to the intestine and invade animals' disease-fighting cells," Wu said. This finding is important information for discovering how and why the bacteria are a...UB scientists report fast, simple method of generating 'designer' RNA catalysts for proteomics
...me" provides an efficient and economic shortcut to attachment of tRNA to unnatural amino acids. The UB method generates the first artificial ribozyme that performs two unique steps that lead to the generation of novel proteins. First, the Sugazyme is programmed to recognize an engineered (i.e. unnatural) tRNA, ...Abnormal chemical bonds cause bleeding disorder
...ormed at any one time are too few to stabilize the attachment of platelets to vWF because as soon as a bond forms, it rapidly releases. In a particular form of von Willebrand's disease, however, the bonds last significantly longer than normal. That extra time allows many additional bonds to form, which stabiliz...RING Finger proteins target cellular molecules for disposal
...ool of Medicine. This proteolysis process involves attachment to other proteins of the small protein, ubiquitin. The attachment is a signal for proteolysis; it tells the proteolytic machine to destroy the ubiquitinated protein, ......ive soap technology that significantly reduces the attachment of bacteria to the skin. They report their findin...l methods. In three clinical studies, the bacteria attachment to the hands washed with the MAT-containing soap was reduced by a statistically significant 50-58% r...