Duke Researchers Discover Candidate Susceptibility Gene For Autoimmune Disease
...ctually located what may be a key gene involved in autoimmune diseasessuch as arthritis and dermatitis. "This...st theirown tissues that represent an inflammatory autoimmune response. By comparingtheir mice with other animals that had similar clinical signs, the researchers......anism's key weapon in the fight against cancer and autoimmune diseases:cells that wander too far from their source of molecular signals naturallyself-destruct. When the self-destruction mechanism is disrupted, though,cancerous tumors made up of rapidly reproducing cells can result....Florida Researchers Discover Gene For Fatal Childhood Disease
... of thousands ofpatients who suffer from cancer or autoimmune disorders such as lupus. Children born wit...ncers in general, and in protecting againstcertain autoimmune disorders. "This is significant for several reasons. Nobody knew what caused thisfatal disease," ...Herpes Virus Strain Identified As A Trigger In Multiple Sclerosis
... may be associated with multiple sclerosis(MS), an autoimmune disorder in which the body attacks its own tissues... "We've thought for a long time that genetics, an autoimmune factor, or somethingin the environment--like a virus--might cause MS," says Dr. Jacobson. "One canc......rectly involved in a mechanism of regulation of autoimmune response. The gene is solely responsible for a systemic autoimmune disease called APECED. Autoimmune diseases comprise a variety of clinical conditions ranging f...Columbia Researchers Identify Gene For Inherited Baldness
...in the United States, are thought to be related to autoimmune disfunctionor stress. The molecular basis of these forms of alopecia remains a mystery. "With the hairless gene, the real basis of hair loss can begin to beunderstood," says Christiano. "We can now look at the cause -- the genesthem...... years ago, when herlaboratory was using different autoimmune mouse models to study multiplesclerosis. As a way of painlessly and permanently separating one group ofimmunized mice from the others, Dr. Heber-Katz's staff pierced their ears, astandard laboratory method for identifying groups. Within weeks, howe...Leftover Fetal Cells May Affect Development Of Scleroderma
...gthe workings of a computer. "Traditionally, the autoimmune diseases are described as your cells attackingyour...e continues, "raise thequestion as to whether some autoimmune diseases are not entirely autoimmune,whether they actually have a component that is non-self. It's ...Researchers From Rockefeller University Develop Novel Method To Fight Cancer
...s the promise ofnew therapies for cancer, AIDS and autoimmune diseases. "We've shown that dendritic cells can trigger an immune response when culturedwith dying cells which carry an antigen, such as proteins from tumors orviruses," says lead author Matthew Albert, B.S., a biomedical fellow in theLaboratory of C...Jefferson Scientists Link Some Cases Of Scleroderma To Damage From Lingering Fetal Cells
...f systemic sclerosis, a form of scleroderma, an autoimmune disease. Systemic sclerosis strikes about three to...esult in death after only a few months. In autoimmune diseases, the normally protective immune system reacts against the body in abnormal ways. In s...Fetal Lead Exposure May Reduce Immunity
...ody's inclination to injure itself in allergic and autoimmune diseases. "Exposure to lead at these levels is not the kind of assault that can destroy the kidneys in 24 hours," Dietert says. "These exposures take time to play out, but ultimately they can be just as problematic relative to quality of life." Wri...Protein Implicated In Multiple Sclerosis
...infectedcells. But in multiple sclerosis and other autoimmune disorders, T cellsmisidentify and attack normal tissue, like soldiers attacking their own. In the current study, Trotter and colleagues isolated T cells from 12 MSpatients. They cultured the cells and exposed them to short strings of aminoaci...Researchers Identify A Protein Critical For T Cell Development And Activation
...cal to understanding immunodeficiencydisorders and autoimmune diseases, such as rheumatoid arthritis, diabetes andsystemic lupus. Activation of the specialized receptor for foreign substances, the T cellantigen receptor, starts a cascade of biochemical events that lead to T cellactivation. This cascade involve...... of viral diseases, multidrug resistancein cancer, autoimmune and inflammatory diseases, and neurodegenerativediseases. There can be no assurance that clinical trials will continue, that initialresults will be predictive of any future results, that drugs under developmentby Vertex or its partners will receive m......MS remain mysterious, the disorder is consideredan autoimmune disease. Immune system cells called T cells cause inflammation inthe brain and spinal cord, which is eventually followed by demyelination, thebreakdown of the protective sheath that surrounds nerve axons. Certain T cellswork in conjunction with prote...Science Announces Top Ten Research Advances Of 1998
...chers provided the firstevidence of a link between autoimmune disorders and infections such as Lymedisease or herpes simplex virus 1. In some people these infections turn intodebilitating long term illnesses even though the bacteria or virus that causedthe infection is long gone. Researchers have now confirmed ...Autoimmune Diseases Study Shows Differences Between Men And Women
...ans spent 18 months assessing what is known about autoimmune diseasesand has now proposed an aggressive researc...fight an invadingbacteria, virus or toxin. But in autoimmune diseases, the body's immune systembegins to attack normal, healthy tissue instead. Rheumatoid arthr......ment orcourse of serious infection, malignancy and autoimmune disease are unknown. Patients with a serious infection, including sepsis, or who are allergic toENBREL or any to its components should not take ENBREL. If patients develop aserious or unusual infection while on ENBREL, they should talk with their do...Heat-Shock Vaccine Stops Bacteria Dead
...ntistshave shown that it's possible to "enlist" an autoimmune mechanism for abeneficial cause -- fighting outside intruders such as bacteria. This new approach may lead to the development ofimproved vaccines for preventing various infectious diseases and possibly for treating cancerous tumors. The emergence of ......ayserve as a basis for medications that will treat autoimmune diseases. Noclinical studies to support this suggestion have yet been performed. IL-18BP may also make it possible to develop a new drug for suppressing theimmune system during organ transplants. Because it is a natural protein, IL-18BP may cause few...