Researchers find key to tuberculosis persistence in the body
...he bug's persistence in the body has been the main barrier to clearing the TB pathogen with drugs. Current treatments require three to five drugs for at least six months, a regimen many patients are unable or unwilling to follow. The drugs can have unpleasant side effects and in some cases cannot be taken be...Decoy cells attract, disarm viruses before infection occurs
...t are administered after the virus enters cells. A barrier in nanodecoy design has been finding a non-toxic polymer to which the sialic acid receptors could be attached. Tomalia's research group is using dendritic polymers large, branched molecules. They vary in size from generation to generation, which aff...Gene barrier in corn may boost trade, environment
... Wisconsin-Madison scientist has found a molecular barrier that, bred into modern hybrid corn, is capable of ...h gene-laden pollen.The ability to build a genetic barrier into hybrid corn is a significant technological advance, one that would permit farmers to assure buy...Bifidobacteria act as a barrier against infection
... predominant species which live in the gut, form a barrier against infection, shows research in Gut. But only...pecialised cells in the gut lining, so producing a barrier against infection. Bifidobacteria are found in breast milk and can be increased by eating more fibre...Cell studies may further gene therapy prospects for head and neck cancer
...l epithelium the overlying squamous cells act as a barrier preventing adenoviral infection of underlying cell...nfected. The overlying tumor cells do not act as a barrier and therefore allow for infection of underlying tumor cells. According to the researchers, the fact...Study illustrates diversification, speciation in biological "islands"
... the groups diverge so that even if the geographic barrier that caused the isolation was removed, they are now separate species and cannot interbreed. An unexpected finding reported by Losos and Schluter is the existence of an island area threshold of 3000 square kilometers (roughly 1,800 square miles), be...LabNotes -- Research highlights from Pacific Northwest National Laboratory
...agents and buffers into the subsurface, creating a barrier that organic contaminants, such as trichloroethylene, move through then are destroyed in the process. Laboratory and field tests conducted at a Washington state Army base have shown positive results in destroying chlorinated solvents. Field tests ind...As the grasslands change and disappear, what happens to the birds?
... that the Great Plains once served as a geographic barrier to woodland birds. As Eastern tree species have moved more and more westward, that barrier becomes easier and easier to overcome. Thus birds from the East are now more likely to mix with bir...UCSF-led study points to pivotal, early event in cancer development
...we've thought senescence could be relied upon as a barrier to continued cell growth," says Tlsty. "Our cell culture study of mammary epithelial cells suggests otherwise. "We hypothesize that the mammary epithelial cells escape from senescence and acquire genomic instability to produce the types of genetic ...Friendly microbes control intestinal genes, study finds
...d genes that control the integrity of the cellular barrier that lines the intestine and separates us from dan...orders. Understanding the regulation of intestinal barrier functions might even reveal how some microbes affect our susceptibilities to food and other allergie...Parasite's sperm-encryption keeps species apart
..., the presence of Wolbachia was the single highest barrier to the interbreeding of the two species, and thus, it is likely the oldest barrier. Wolbachia infects as much as 20 percent of all insect species, and tends to infect large percentages of the individuals in those species. It was first noticed more ...Molecular mimicry and neurodegenerative disease
...halitis, in which antibodies cross the blood-brain barrier and bind to glutamate-gated calcium channels (GluRs). Binding of autoantibodies to GluR3 activates the channel and causes the death of specific populations of neurons. Although this condition can be modeled by immunizing animals with the GluR3 prote......ies encourage unsustainable development on coastal barrier islands by offering subsidized flood insurance policies, beach-building funds, road construction money, bridge construction costs, and financing for additional infrastructure. The resulting need for nourishment programs is costly. For example, the Wa...Eating less may protect nerve cells
... we can injure these neurons without breaching the barrier between the bloodstream and the brain. That way, ...e damage isnt caused by changes in the blood-brain barrier that might not relate directly to the initial ischemic injury." Neufeld suggests these findings mig...Genetically engineered skin substitute is designed to promote wound healing
...ndreadis explained, the engineered tissue has good barrier function, preventing dehydration and protecting against pathogens. "This is very important for burn patients who have lost a substantial fraction of their total body surface area and who suffer from excessive dehydration and bacterial infections," h...A stomach enzyme deficit may place women at more risk from drinking alcohol
...m, essentially functioning as a kind of protective barrier against excessive rise of blood alcohol. This process is referred to as "first-pass metabolism," because some of the alcohol is removed by metabolism on its 'first pass' through the stomach. As a result of first-pass metabolism, the blood level ach...A dose of prions might slow the progress of prion diseases.
... Such experiments have also revealed a species barrier to prion transmission. For example, abnormal mouse PrP is good at infecting hamsters, but hamster PrP isn't so good at infecting mice. So the team looked to see if adding normal hamster PrP to the brain of a mouse already infected by abnormal mouse P...Malaria research and training benefits global community
... and the disease will continue to be a substantial barrier to the economic and social development of malaria-endemic regions and a threat to the millions of people who travel to those regions each year. In 1997, an international alliance of research and public health agencies and African scientists launched ...UC San Francisco patents method for delivering normal genes in a pill
...the scientific advisory board for Genteric. "That barrier has been overcome. We have shown that proteins from genes administered orally are secreted into the blood stream." The UCSF researchers demonstrated that orally administered genes induce the secretion of proteins through a series of studies involving...... broken through what was considered an impermeable barrier that kept half the genes in some cells "silent." The surprising results, in which these heated genes reached 500 times their normal rate of expression, could lead to better understanding of cellular processes involved in aging, fever and toxicity. ...