Researchers develop computer application to 'read' medical literature, find data relationships
...ousands of papers." The proprietary software, the basis for a new company called etexx Biopharmaceuticals (www.etexxbio.com), has already helped predict new uses for existing drugs to combat cardiac disease. The UT Southwestern researchers' work with this computer application appears in the current issue ...Small-molecule inhibitors of anthrax lethal factor identified
... can be built. This pharmacophore will serve as a basis for directing future efforts to develop LF inhibitors with enhanced potency. "These studies have provided us with a road map to the rational design of more potent, highly selective lethal factor inhibitors," said lead author Sina Bavari of USAMRIID...Primates trade smell for sight
...ctory receptor (OR) genes, which are the molecular basis for the sense of smell, and the acquisition of full trichromatic color vision in primates. While humans, nonhuman primates, and mice have roughly the same number of OR genes, in humans a high percentage (60%) of these are nonfunctional so-calle...Reward mechanism involved in addiction likely regulates pair bonds between monogamous animals
...ding could have implications for understanding the basis of romantic love and disorders of the ability to f...ides an ideal animal model for studying the neural basis of social attachment. In previous studies, CBN scientists have determined: The genes for vasopress...New advance to combat antibiotic-resistant pneumonia and malaria
...were three years ago in terms of understanding the basis for resistance in these organisms," said Trumpower. The co-authors of the study are Dr. Steven Meshnick from the University of North Carolina and Dr. Brigitte Meunier from the Wolfson Institute for Biomedical Research in London. The study was fund...Transgenic mosquitoes are less fertile than their counterparts in nature
...he magnitude of it. "Once we determine the genetic basis of these fitness costs it should be possible to generate competitive mosquitoes that will prevent the transmission of human diseases," he said. Atkinson uses a jelly fish "marker gene" that glows under ultraviolet light so he can quickly identify wh...Research reveals brain has biological mechanism to block unwanted memories
...und on this that there is a clear neurobiological basis for motivated forgetting," Anderson said. "Repression has been a vague and controversial construct for over a century, in part because it has been unclear how such a mechanism could be implemented in the brain. The study provides a clear model for ho...International Conference on Emerging Infectious Diseases
...ns will be available on a first-come, first-served basis by contacting Jim Sliwa, ASM Office of Communications at jsliwa@asmusa.org or by phone 202-942-9297. Preliminary program and hotel information are currently available online at www.iceid.org . More detailed information, including a full program,...Tiny heaters may pave way for easier tissue engineering, medical sensors
...placement tissue for injured patients and form the basis for medical sensors that could quickly detect pathogens, according to researchers at the University of Washington who are the first to demonstrate the process. The key to the technique, according to Associate Professor Karl Böhringer in the UW'...BRCA mutations do not increase risk of colorectal cancer
...mutations (20). "We found no strong common genetic basis between colorectal and breast cancer," says Gruber. "They are different diseases with different genetic factors." In the second part of the study, scientists compared whether a family history of breast cancer in a parent, sister or daughter was assoc...Beagle 2 team still hopes to repeat Mars landing success
...ng our way through the logic and fault tree on the basis that Beagle 2 is on the surface of Mars and for some reason is failing to talk to us," said Dr. Sims. "There are six or seven scenarios that we're still working through and we still can't eliminate any of those." However, possible failure scenarios ...A big surprise: Young nerve cells can rewind their developmental clocks
...lled Foxg1. The finding could potentially form the basis of a new method to push progenitor cells in the brain to generate a far wider array of tissue than is now possible. The study, led by researchers at NYU School of Medicine, is published in the January 2, 2004 issue of Science magazine. "W...Third set of awards are announced under interagency biodiversity program
...eusch, said that "natural products have formed the basis of over half of currently available medicinal therapies around the world. Recentadvances in drug discovery science and botanicals evaluation, coupled with the rapid disappearance of organisms from which new medicines may be derived, make this work mo...Virginia Tech-led group receives third five-year international biodiversity grant
... a certain kind of tourists, providing an economic basis for preserving the park and it's biodiversity," says Kingston. The other partners in the group met with villagers near the collection site and asked them what they needed. "Members of the group built a grain storage facility, which allows farmers to ...CSIRO scientist wins highest global award for fisheries research
... research team to develop and apply the scientific basis for multiple-use planning and management of marine ecosystems in Australia Exclusive Economic Zone, including the North West Shelf region and Australia's South East. This emphasis on understanding and managing fisheries and other human uses of marine...Study finds evidence for global methane release about 600 million years ago
...bonate deposits had been discounted by many on the basis of the lack of expected isotopic heterogeneity," said Nicholas Christie-Blick, a professor of earth and environmental sciences at the Lamont-Doherty Earth Observatory of Columbia University. "If the methane hydrate hypothesis is borne out by new stud...Discovery of brain disorder gene paves way for genetic test
...rt Association. Earlier research into the genetic basis of CCM found that three separate genes in the huma...stigators have also begun exploring the biological basis of CCM in mice with the disease....Scripps Research receives $3 million anonymous donation
...ke or relapse. "Once we know the circuits and the basis for alcoholism, we can develop new targeted treatments," says Koob. "There are a number of possible neurotransmitter candidates to focus on." One of these, called gamma amino butyric acid (GABA), is the main inhibitory neurotransmitter in the brain....'Suicide proteins' contribute to sperm creation
...poptotic process. Insights into the molecular basis of caspase activation in sperm individualization could provide clues to male infertility and suggest possible treatments. ...Map of genes in plant root yields new tool for exploring tissue development
...level of resolution of gene expression on a global basis for any organism," he said. "Other genomic studies, in which whole tissues were ground up and their global gene expression profiles determined, certainly generated much useful information. However, critical information on the mechanisms of developme...