Small, Smac-like molecule encourages death of cancer cells
...researchers report on this new compound and how it behaves like the cellular protein Smac, a molecule that lifts barriers to cell death. Dr. Xiaodong Wang, professor of biochemistry and one of the authors of the Science paper, discovered Smac in 2000. "Every cell in our body has a self-destruction apparatus ...Enzyme activation appears key in helping internal clock tell night from day
... sleep and wakefulness. "Without PKG-II, the clock behaves as if locked in a dynamic loop that encompasses the biochemical state of late night," the researchers wrote. "By potentially interacting with CLOCK (a critical protein of the central clockwork) during its phosphorylation, PKG-II may influence core c......ormal mouse chromosome. This artificial chromosome behaves like a normal one in mice: it is duplicated when cells divide and is passed from generation to generation (New Scientist, 8 July 2000, p 7). Now the company has shown how the chromosome could be used for gene therapy. The researchers started with two...Altered protein involved in a novel link to Alzheimer's disease
... protein, p35, to break. But the newly created p25 behaves very differently from the protein from which it was carved out, says Dr. Tsai. Unlike its shorter-lived parent, p25 keeps accumulating in the brain. It causes its most severe damage indirectly, however, by the way it alters the behavior of an enzyme ...Malignant breast cancer cells to revert to normal with manipulation
...tecture of the tissue is important in how a tissue behaves and how it responds to chemotherapeutic agents....Rare ant may help solve some mysteries of social evolution
...ommon to its slave-maker ant relatives. Rather, it behaves much like the unwelcome in-laws who come to visit for an undetermined length of time. Numerous L. minutissimus queens move into a new colony and attach themselves to host queens. But researchers aren't sure how L. minutissimus moves from colony to co...Unraveling a protein, researchers uncover mechanics of anti-cancer agent
... they show that the fibronectin known as FN-III-1 behaves differently mechanically than other type-three modules. The paper was placed online Dec. 1 at the PNAS Web site. "Type 3-1 stands out," said Klaus Schulten, holder of the Swanlund Chair in Physics at Illinois and director of the theoretical and compu...Book traces the history and mystery of the Deschutes River
...his river into a coherent picture of how the river behaves and responds to human interventions like dams," sa... of any river of its size in the United States and behaves like a large, spring-fed creek. It possesses one of the lowest sediment yields of any river in the ......orque in the opposite direction. The molecule then behaves as a reversible force-torque converter," said Bustamante. "If you attached rotational elements to the molecule, when you pulled the molecule, it would begin rotating and would drive the molecule as a motor."...The 'fixed' hotspot that created Hawaii was not stationary after all, study finds
...c pole and become locked in place. "The magnetite behaves like miniature compass needles: The closer they are to the Earth's magnetic pole, the steeper their position," Scholl explained. Researchers were able to verify the latitudes at which the seamounts formed by determining the angles at which the magnet...Chemical in broccoli blocks growth of prostate cancer cells
... "DIM is chemically different than Casodex, but it behaves similarly in how it blocks the effects of androgen," said Le, who received her PhD in molecular and biochemical nutrition in 2002. These latest findings appear to add new burnish for this class of chemicals that has already shown promise in prior stu...Mathematical models reveal 'molten' and 'glassy' states of RNA
... The models -- showing that RNA behaves differently depending on the ... create a double-helix structure. RNA behaves very much like a DNA molecule that has lost its complementary partner. In order...Rainforests at risk: Where theres smoke, theres even more fire
...score a crucial need to better understand how fire behaves in rainforests and how unintended fires can be detected and contained. Fire in a rainforest behaves differently than fire in temperate forests, such as in North America. Rather than rage, rainforest f...Structure of key breast cancer receptor determined
... The findings also explain why the HER2 receptor behaves so differently from its relatives HER1, HER3 and HER4, says Leahy, in whose laboratory the structure of HER3 was deciphered last summer. While all four proteins are similar in the sequence of their building blocks, only excess HER2 leads to uncontrol...Expanding the genetic code: the worlds first truly unnatural organism
...ducts where it could 'get out.'" How this organism behaves in future experiments will determine, in part, where the research goes from here. "We are now focusing on more 'useful' unnatural amino acids such as ketone- and PEG-containing amino acids," Anderson says. PEG stands for polyethylene glycol, a polyme...Firefly light illuminates course of herpes infection in mice
...1 virus. After determining that the modified virus behaves in cells like the normal virus, they injected the modified virus into several locations in mice, including the brain and abdominal cavity. Daily for nine days, the mice were injected with luciferin, a compound also produced by fireflies that emits l...Research reveals how an acid dissolves, molecule by molecule
...This more precise understanding of how the process behaves on a molecular level could aid scientists in improving control over chemical reactions, enabling them to better achieve the desired result," Hurley says. The research also likely will impact biological research. Among the factors that the researche...AAAS at the BA: Whale food, winners and losers in Antarctica and solar insights
...d theoretical idea implying that a turbulent fluid behaves like a very viscous fluid, is still used in solar physics but has had to be thrown out in the atmospheric case because observations show it to be wrong. The theoretical reasons are now well understood. The eddy viscosity idea is still accepted in th...Tomorrow's super robots may owe their mobility to a cockroachs legs today
...d in a direction orthogonal to the joint direction behaves similarly to a viscoelastic material. The exponential nature of the force relaxation curves suggests viscoelasticity. The hysteretic nature of the force-displacement curves indicates that there is energy loss due to the internal friction, which is a ...New method of DNA testing promises to transform medical diagnostics
...ittle molecular side chains a charged group, which behaves like a soap, thereby enabling the polymer to be dissolved in water. Bazan and Gaylord made a water-soluble conjugated polymer that emits blue light when irradiated with ultraviolet light. Put the polymer in water, shine ultraviolet light on the solu...