Duke Researchers Find Second Gene Linked To Blood Vessel Disorder
...he potent growth factor, transforminggrowth factor beta (TGF-_). Researchers are only beginning to unravel howTGF-_ works. Receptors for TGF-_ are found on the surface of virtually every cell ofthe body. When TGF-_ binds to these receptors, signals are relayed inside the cell. Thecellular response to TG...Gene Discovery Could Overcome Aluminum Barrier To Higher Wheat Yields Worldwide
... cucumbers that, when preserved as pickles, retain beta carotene that the body converts to vitamin A. Vitamin A is necessary for normal vision, bone growth and tooth development. Cucumbers grow well in hot, humid climates of developing countries where many children suffer vitamin A deficiencies. [Conta...Chemists Develop High-Throughput Method To Synthesize And Screen Novel Antibiotics
...f these antibiotics fall intothe category known as beta lactams. Chemistry graduate student Jie Wang will ...ss takes about two days. "We have over 1,000 novel beta lactams," said Day. "Most ofthem test out as being very effective against a wide range ofbacteria." ...Mystery Of Vital Cell Protein Solved After 30 Years
...hows that eachtubulin monomer -- the alpha and the beta -- is a compact molecular structurewith three func...structure. Each monomeris formed by a core of two beta sheets (blue and green) surrounded by helices,and each binds to a guanine nucleotide (pink). In add...DT104 Advice:How To Slow Salmonella Spread
...manure slurry pits andstagnant water. UV rays and beta and gamma irradiation have a bactericidaleffect on salmonella, as do cleaning solutions of chlorine, iodines, ammoniumsand phenolics. However, many salmonella strains are relatively resistant tofood-preservation methods such as drying, salting and s...Studies Underscore Link Between Nutrition And Nonmelanoma Skin Cancers
...t from increasing their intake of foods containing beta carotene, suchas carrots, sweet potatoes and broccoli." Vitamin E has been shown to reduce the development of ultravioletlight-induced tumors in animals, he reported, but because Vitamin E can interactwith other medications, Arbesman caution...Study Shows: Just Say NO To Bone Loss
...okines; and the role of transforming growth factor beta (TGF beta) in thebone resorption process. "What we really want to do is refine our understanding of the nitric oxidemechanism in osteoclasts and pinpoint more precisely how NO synthases areactually regulated," Osdoby says. "Our working hypothesis is...Fruits And Vegetables Protect Lungs
...ers reported. Antioxidants are substances, such as beta carotene and selenium, that work in different ways...er understand these associations. The antioxidant beta carotene, a compound of carotene found in dark green, dark yellow and orange vegetables and fruits, ...Duke Researchers Genetically Engineer Mice To Block Heart Enlargement
...egimensconsisting of multiple medications, such as beta blockers and ACE-inhibitors, toblock the various hormones that produce a strain on the heart. If these drugsfail and the disease progresses, patients can receive a heart transplant as alast resort. "Right now patients with hypertension are tr...New RNA Repair May Lead To More Successful Gene Therapy
...one day we will be able to cure - notjust treat -- beta thalassemia, an inherited deficiency of hemoglobin...n production, he said. Insevere cases of untreated beta thalassemia, those errors lead to acute anemiaand death at a young age. "The advantage of ou...Perkin-Elmer To Introduce New Instrument Based On Breakthrough DNA Analysis Technology
.... Venter of a new genomics company which will be a beta test sitefor the instrument. The new company's strategy will be centered on a planto substantially complete the sequencing of the human genome in three years. The 3700 DNA Analyzer, to be priced at approximately $300,000, is thefirst model of a new ...Toxic Protein That Interferes With Brain Signals May Trigger Onset Of Alzheimer's Disease
... ADDLs are a surprising new form of the amyloid beta protein. Amyloidbeta has been known for years to a...d thatADDLs, which are minuscule clumps of amyloid beta only a tiny fraction the sizeof a fiber, may be more relevant to the disease process. Their ...University Of Georgia Researchers Help Design Decision Support System For Forest Managers And Owners
...e abundance. The Forest Service is testing beta versions of NED, and the firstfull-scale prototype will probably be released by the end of the summer, Nutesaid....Duke Researchers Call Gene Therapy A Promising Strategy For Sickle Cell Anemia
...sickle cell anemia because thecell's production of beta globin is precisely regulated. Sullenger's strategy simultaneously eliminates defective protein andcreates new working copies of the globin protein. This corrected gene is alsodesigned to make a fetal form of the globin protein. The fetal glo......munosuppressant protein transforming growth factor beta (TGF$1) intodendritic cells taken from the bone marrow of one mouse strain. Next, they tookthese DCs and transplanted them along with a heart to another immunologicallydistinct strain of mice. These altered DCs prolonged the survival of the newhear...Studies Rebut Concept That Body Stores Vitamin A-Making Substances
... can besubstituted. Some carotenoids, particularly beta carotene, act as precursors tovitamin A. The carot...is vitaminA precursor." There was a rapid loss of beta carotene from the two pools in the gerbils'liver. One pool was lost slowly; the second,which include......it was reported here today. The protein, amyloid beta peptide (AB), is the major constituent of the senileplaques found in Alzheimer brains, and it generates oxygen free radicals thatattack and kill brain cells, said Allan Butterfield, Ph.D., professor ofchemistry and director of the Center for Membrane...Duke Scientist Reports Advances In Gene Therapy For Heart Failure
...wed that mice genetically altered toproduce excess beta adrenergic receptors (bARs) have supercharged hear... "Our studies have shown that a malfunctioning beta adrenergic receptorsystem leads directly to heart failure," Koch said. "By contrast, boostinglevels ...Scientists Show For The First Time How Leprosy Bug Targets Peripheral Nerves
... outer membrane alphasubunit and the transmembrane beta subunit. alpha-Dystroglycan interacts withlaminin-2 in the basal lamina, while beta-dystroglycan binds to cytoskeletalproteins in the peripheral nerves. In the Science paper, the researchers used a cell culture technique developed byco-author James S......y of anti-oxidants such asvitamin E, vitamin C and beta carotene, all of which fight the tendency ofoxygen...ups, one of which was given ananti-oxidant diet of beta carotene and vitamins E and C. After 21 months,the rate of muscle oxidation for the rats in the ant...