Climate change plus human pressure caused large mammal extinctions in late Pleistocene
... of the Earth's mammals could be as dire as it was between 50,000 and 10,000 years ago, when a combination of...hange were the one-two punch that drove extinction between 50,000 and 10,000 years ago, and the same thing is happening in a major way today." Because climate ...Veterinary Memorial Fund transforms grief into promise
...s reach out to their clients. It has built bridges between the association and the college. And most importantly, it has funded critical research that has improved the quality of animal care we can deliver." The Virginia-Maryland Regional College of Veterinary Medicine (VMRCVM) is a two-state, th...NIH awards $18.2m to The Burnham Institute to develop Center on Proteolytic Pathways
...nstrumental infrastructure needed to close the gap between discovery and application of new knowledge. The Burnham's "Center on Proteolytic Pathways" is one of two new centers launching the "National Technology Centers Network and Pathways Directory" included in the "NIH Roadmap for Medical Research", implem...Lycopene slows human prostate tumour growth in mice and combined with vitamin E is even better
...ses may not work and that there is an optimal dose between the two extremes." The study showed that the lycopene and vitamin E were effectively taken up in the mice prostates in the same form as they are in humans, said Dr. Limpens. Dr. Limpens said the findings seem promising, but it was early days yet and...UT Southwestern receives $1.78 million grant for obesity research as part of NIH Roadmap initiative
...s attributable to obesity annually is estimated at between 285,000 and 325,000 people, second only to tobacco smoking as a cause of preventable death. "Obesity is a deceptively simple problem, as it is essentially energy input vs. energy output," Dr. Malloy said. "However, it's not obvious yet why obesity sh...Cigarette smoke causes breaks in DNA and defects to a cell's chromosomes, Pitt study finds
...piece of taffy, forming so-called anaphase bridges between its two ends. Eventually, these chromosomes either tear apart, leaving two broken pieces, or if they don't break apart, the abnormal, elongated chromosomes may persist after anaphase is completed. Either way, a major change in the structure of the ch...Molecular motor implicated in tissue remodeling
...t we are exploring further, they create a relation between cells and the structures in the matrix. It's a very elegant system." ...EMBO Gold Medal 2004 goes to Spanish scientist
...hem to be tumour-prone; demonstration of interplay between the status of the retinoblastoma family of proteins and the length of the telomeres; and demonstration that telomere maintenance requires both telomerase activity and homologous recombination. Since 1997, Mara Blasco has published more than 65 papers...Researchers find color sensitive atomic switch in bacteria
...ifferent colors drives this protein back and forth between two differently colored states of the protein," said co-senior author John L. Spudich, Ph.D., director of the Center for Membrane Biology in the UT Medical School Department of Biochemistry and Molecular Biology. "Chemical analysis and spectroscopic ...New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
...ans-Retinoic Acid a vitamin A-based substance) is between 60 and 80 percent. "There have been a few studies done using arsenic trioxide on a limited number of newly diagnosed patients, but we are the first group to suggest that it is acceptable as a first-line treatment," said Dr. Ghavamzadeh. "The results ...DNA lends scientists a hand, revealing new chemical reactions
...s in laboratory reactors. In nature, the reactions between these highly dilute molecules are directed by enzymes that selectively bring certain biological reactants together. Liu and his colleagues use DNA as a similar type of intermediary to bring together synthetic small molecules that are otherwise too di...Alzheimer's disease is not accelerated aging
... of Neuron, that points out recurring distinctions between factors that influence what he calls executive fun...f the Alzheimer type, they found clear differences between the effects of normal aging and Alzheimer's disease. According to Head, the corpus callosum was smal...UT Southwestern biochemist honored with NIH Director's Pioneer Award
...rders, while a clearer picture of the relationship between circadian rhythms and depression might impact drug discovery in the treatment of potentially significant forms of mood disorder. "Taking major risks and achieving momentous accomplishments have characterized Steve McKnight's career," said Dr. K...St. Petersburg/New Haven Partnership for HIV/AIDS Care, Treatment and Support launched
... AIDS (CIRA). The goal is to develop a partnership between the Yale School of Medicine and the New Haven community with health professionals in St. Petersburg, Russia to provide training in HIV/AIDS care, treatment and support. The program involves exchanges of Americans and Russians who will develop a commu...Safety of isoflavones in dietary supplements targeted by Illinois initiative
... Another group will look at the mechanisms at work between isoflavones and estrogen receptors." While most food scientists stress the importance of consuming soy as part of a whole-foods approach, there has been a proliferation of dietary supplements and food additives containing isoflavone extracts. The...Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
...e disease, listeriosis has a high fatality rate of between 20 and 30 percent. It made headlines two years ago when 20 people, including several children, died of listeriosis from tainted hamburger, forcing the largest meat recall in history. Several thousand people come down with listeriosis each year, and s...Award winning researchers reveal potential new role for Glivec
...was re-arranged in DFSP, involving a translocation between chromosomes 17 and 22. "It was intuitive to try imatinib in the disease because this translocation results in over expression of PDGFB and imatinib is an inhibitor for the PDGFB receptor," said Dr. McArthur. He said there had been reports of imatini...Trial shows which brain cancer patients benefit from temozolomide
...rther multidisciplinary research, bridging the gap between basic research and clinical practice," said Dr. Hegi. "Whether temozolomide will cure some patients remains to be demonstrated. Glioblastoma remains a dreadful disease without a cure, and there is still a long way to go."...Genetic differences might help distinguish thyroid cancers
...sion of only four or five genes. Distinguishing between the two cancers is important because the malignanc...instances where the pathologist cannot distinguish between FTC and PTC," says study leader Charis Eng, the Dorothy E. Klotz Chair of Cancer Research and direct...New Arizona State center brings science to policy on issues of water resources and urban growth
... Gober. "Our theme is the creation of partnerships between scientists and decision makers to study and understand the complex relationships between rapidly growing population, finite water resources and climatic variability." "With DCDC...