Tag: "bind" at biology news
UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
...ns, as is Nef's function. (Although Nef is able to bind
well to the three proteins in the absence of the b...eir synthesized molecules and Nef both competed to bind
with the cellular proteins. Each time the molecules succeeded, Nef was dislodged from binding to the...
Researchers ID chlorophyll-regulating gene
...yme, called protochlorophyllide oxidoreductase, to bind
with typical levels of protochlorophyll. But not enough of the enzyme is produced to handle the overabundance of unbound protochlorophyll churned out by the mutant seedlings. The researchers say the ability of plants to precisely regulate pr...
Anthrax enzyme images reveal secrets of antibiotic resistance, suggest new drug design
...eria resistant to antibiotic molecules designed to bind
there. This molecule (5-nitro-6-methylamino-isocyt...part of DHPS, the enzyme would lose the ability to bind
to DHPP and help the cell make folate," White said, "and if the enzyme mutated enough to avoid the a...
'Smart antibiotics' may result from UCLA research
...eria, allowing them to diversify their proteins to bind
to a large variety of receptors. The team discover...e to generate proteins in the laboratory that will bind
to almost any molecule of interest. "We think we can make proteins that bind
to peptides, and make p...
Scientists discover potential new way to control drug-resistant bacteria
...hat allow them to quickly change their proteins to bind
to different cell receptors. The researchers, who ...y to generate proteins in the laboratory that will bind
to almost any molecule of interest. ...
Amyloid fibers sprout one step at a time
...g the molecular details of how individual monomers bind
to a growing fibril....
Researchers develop fast track way to discover how cells are regulated
... a transcription factor known as DAF-12 that could bind
to the regulatory sequence, and is absolutely necessary for the worm pharynx to respond to nutritional cues." Mango's work in the future will focus on questions relating to regulatory mechanisms in cell metabolism and cell differentiation, both i...
First glimpse of DNA binding to viral enzyme
... The scientists didn't expect the viral DNA to bind
to the protease, but they figured they should look just to rule out such an interaction. "It was something we had to do, to make sure they did not interact," Mangel said. The discovery that the viral DNA interacts with the protease was unprecedented ...
Images of 'tail' of protein needed for cell multiplication suggest anticancer drug targets
...1 close to NEDD8 so those two proteins can rapidly bind
to each other and begin the process of assembling the on switch." The workshop's ability to quickly assemble the on switch is important because it reflects the need for cells to be able to react swiftly to a changing environment, according to Martine...
Novel IBD therapeutic approaches reported from Washington Univ., Barcelona, LSU at APS meeting
...e adhesion glycoproteins that enable leukocytes to bind
to vascular endothelial cells. Drugs that specifically target adhesion molecules involved in leukocyte recruitment are effective in treating intestinal inflammation. They said that experimental models have shown that blockade of VLA-4, VCAM-1 and P...
Common cold virus can cause polio in mice when injected into muscles
...d poliovirus cause distinct illnesses because they bind
to different docking sites, called receptors, on host cell surfaces. The current study turned that belief on its head, said Gromeier. Poliomyelitis has long been regarded as the signature of poliovirus, a virus that recognizes and binds to the CD155 ...
'Defensive' action by influenza viruses demonstrated by Hebrew university researcher
...that the blocking element in the drug is unable to bind
and create a seal, or by widening its channel so that the blocker can get in, but can't totally seal the channel. Arkin notes that the latter action is the more surprising and unexpected one. While counteraction of the virus to the drug has been prev...
Optimizing protein's 'death domain' halts leukemia in laboratory study
...Amino acids positioned on the surface of the coils bind
to amino acids on anti-death molecules such as BCL-2 and inhibit their activity. BCL-2, a key part of the apopotosis mechanism, was discovered by Korsmeyer. Building on other recent work, Walensky sought to remove the alpha-helical BH3 subunit from t...
Essential smell gene may provide key to new insect repellents
...ppendage near the fly mouth. The odorant molecules bind
to receptors on the neurons, fitting like chemical keys into the lock-like receptors, and set off a series of signals that the brain perceives as smell. A different gene codes for each kind of receptor, and the Or83b receptor is unusual in two ways. ...
Scientists discover proteins involved in spread of HIV-1 infection
...es also managed to identify regions of TSG101 that bind
to VPS28 and VPS37, and showed that theVPS28 binding region is essential for HIV-1 budding. This information could potentially be used to develop drugs that target these binding regions and disrupt HIV-1 budding, preventing infection from spreading. ...
The future of HIV therapeutics is brightening, according to Gladstone Institutes Director
...r antagonists that interfere with HIV's ability to bind
to CCR5, one of two key surface receptors needed f...tiviral action of APOBEC3G. The fact that Vif must bind
to APOBEC3G and recruit enzymes triggering APOBEC3G degradation provides an exciting window of oppor...
New genetic research demonstrates possible cause of inherited form of Parkinson's disease
...tant forms of alpha-synuclein protein was shown to bind
to protein disposal sites within dopamine neurons. This creates a blockage that leads to the eventual death of the neurons. The study was conducted in dopamine neurons taken from mice. Dr. Sulzer likens the situation to a garbage truck stalling at...
Protein fishing in America: The movie
...hat depend on calcium for cell signaling, that can bind
with various protein species. Lu's group has assembled an elaborate instrument at PNNL's W.R. Wiley Environmental Molecular Sciences Laboratory. In the instrument, fluorescent-dye-tagged proteins are embedded in a gel and probed by a continuous-beam,...
Images reveal how rotavirus - leading cause of diarrhea - enters cells
...ttack the cell and positioning the spike "head" to bind
to the surface of the target cell. Then, in a second rearrangement, the spikes fold back, and VP4 takes on a folded-umbrella structure with three "panels." Dormitzer and colleagues speculate that this folding motion causes the spike's "body" componen...
Bright idea could doom cancer and viruses, say Purdue scientists
... compounds to poison cancer cells. These compounds bind
DNA in the cellular nucleus and render the cell unable to reproduce, effectively destroying it. The trouble is, such chemicals also kill many other healthy cells in the body in the process. "That's the reason cancer patients often lose their hair," M...
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