Canadian scientists unlock secret of calcium waves in cells
... more research, understanding how the molecule IP3 binds with its receptor is critical to regulating calcium levels in cells and ensuring normal brain function."...New technique reveals drug resistance in breast cancer tumors
...mixture onto fingernail-sized gene chips. The mRNA binds to its complementary probe on the chip. Afterward, scientists shine a special light on the chip. They can tell by the intensity of light how much messenger RNA -- and hence, copies of each gene -- is present on the chip. Thus, the researchers obtain ...UT Southwestern Nobelists find protein structure that may help fight high cholesterol
...ke substances that clog arteries. The LDL receptor binds LDL in the liver and clears it from the blood by pulling cholesterol inside the cells, where it is metabolized to replenish hormones, the cell membrane, vitamin D and other products. "This research will help scientists understand the mechanics of how...Critical therapeutics is awarded U.S. patents for methods to diagnose and treat inflammatory disease
...ceutical composition comprised of an antibody that binds HMGB1. The antibody, in turn, is believed to dramatically reduce the "cytokine cascade," or overproduction, of HMGB1 that triggers sepsis and other inflammatory diseases. U.S. patent number 6,448,223 B1, "Antagonists of HMGB1 for Treating Inflammat...Structure of pain-modulating enzyme described by scientists at the Scripps Research Institute
...des in response to a peripheral pain stimulus. THC binds to "CB-1" receptors on cells on the rostral ventro...rnal bliss." When the body senses pain, anandamide binds to CB-1 and nullifies pain by blocking the signaling. However, this effect is weak and short-lived a...'Knot' to be undone, researchers discover unusual protein structure
...now the protein's function. They speculate that it binds to RNA, a chemical cousin of the genetic material DNA, and helps process this molecule. The PSI, currently in its pilot phase, expects to move into production phase by the end of 2005. By the end of the pilot phase, each center will aim to produce 1...Versatile immunosuppressant drug may have new role in radiotherapy for cancer
...lling pathway to promote tumour growth. Rapamycin binds to a receptor protein (FKBP12) and the rapamycin/FKB12 complex then binds to mTOR and prevents interaction of mTOR with target proteins in this signalling pathway. "It's alre...Aspirin inhibits ovarian cancer growth, lab study finds
... a receptor protein on the tumor cell surface that binds to a substance that stimulates growth. The protein is elevated in a third of ovarian cancers. Jeanne Becker, PhD, an associate professor in the Department of Obstetrics and Gynecology, was senior author for the study, along with co-author Janet Drak...Scientists identify role of important cancer protein
...e cytoplasmic signaling proteins, so that when Ski binds to the nuclear signaling proteins, the cytoplasmic...t confirmed these results by also showing that Ski binds to nuclear signaling proteins. "These results force us to do some rethinking about the role of Ski i...Tailor-made cancer drugs: Wave of the future?
... already determined the rules of base pairing -- A binds with T and G pairs with C -- a system called "Wats...he benefit is that a single strand of RNA actually binds tighter to a strand of PNA than it does to itself. So, the prodrug and the catalytic components eac...UIC chemists identify compound that inhibits cell migration
...tructure to improve its activity, find out what it binds in the cell, and how," Fenteany said. "We're working to find the protein it binds, and we have a candidate. Since the small molecule targets the protein and inhibits the process of cell movement, the protein becomes a potential target for drug develo...Purdue corrals new Trojan horse to replace wayward genes in mice
...rus G," Sanders said. "It has a protein shell that binds to just about any kind of cell, which is terrific if you want lots of options for gene therapy. The trouble is, the proteins are toxic to most cells as well, which is, of course, not so good." When the team of Beverly Davidson and Paul McCray at the ...RRF recycles form, not exact function
...slation? According to Kaji and his colleagues, RRF binds to different locations within the ribosomal complex at different times. It seems that, if the ribosome is the protein factory, the RRF is the foreman, moving from location to location to 'supervise' the end of the assembly line. When the new protein ...Revealed: How a master protein remodels chromosomes to orchestrate gene expression
...B1 does not bind to exposed DNA bases; instead, it binds along the minor groove of double-stranded DNA, where there are well mixed As, Ts, and Cs (cystosine bases) on one strand. While some other proteins, which occur in many cell types, also bind to BURs, SATB1 is cell-type specific; it is found principal...New insight into fragile X syndrome: Scientists identify possible link to RNAi
...led fragile X mental retardation protein (FMRP) -- binds to RNA and is thought to regulate the expression of specific genes during neural development, but the mode of FMRP action in cells is yet to be defined. This work provides some important clues. Using Drosophila as a model organism, Drs. Siomi and Ha...Clay sprays control HABS; disease may affect more than salmon
...eawater, is sprayed over the algal bloom, where it binds with the harmful organisms and sinks to the bottom. In laboratory experiments meant to mimic field conditions, results showed that the clay removed 80 to 90 percent of the toxins in 2-hour treatments. Korea and Japan have used clay to control HABs...Study sheds light on mess in polluted streams
...ut it also possesses another dangerous quality: It binds to toxic metals, including mercury, lead and cadmium, and transports them far downstream. "This combination of floc and metals pollutes streams," said William Casey, a UC Davis professor of aqueous geochemistry and one author of the new report. "Bad ...One gene, two important proteins
...essage, such as a polypeptide hormone or cytokine, binds to a receptor located on the outside of a cell, which then leads to the activation of a "kinase" enzyme called "JAK." JAK, in turn, activates the STAT proteins ("Signal Transducers and Activators of Transcription"), which subsequently travel to the n...Breast cancer gene repairs damaged DNA
...scovered that another domain in the BRCA2 fragment binds double-stranded DNA, although they have not yet established conclusively that the domain by itself binds double-stranded DNA. Pavletich's group also showed that BRCA2 stimulates the activity of an enzyme c......swer this question, the researchers showed that it binds to a molecule called 11-cis--retinal, gives a characteristic absorption spectrum in the visible range and activates in response to light. In order to see color, humans have three types of visual receptors, sensitive to red, green and blue light, but ...