Two Long-sought Diabetes Gene Found
... activity," said Bell. "The identification of this biochemical signal could lead to new approaches for treating diabetes." NIDDM affects an estimated 100 million people worldwide, including 15 million in the United States, where it is the seventh leading cause of death. According to the National Institute of Dia...Ten Years of Progress For Superfund Basic Research Program
...present theirfindings concerning the molecular and biochemical mechanisms ofdegradation and the mutagenesis of toxic metals. Kathleen Dixon,associate professor and associate director of the department ofenvironmental health, will discuss her findings on the mutagenicmechanisms of chromium. She has looked at the ...New Study Shows Steps Leading To Colon Cancer
...o work with -- the Cell paper explains the precise biochemical functions of armadillo, Peifer said. It turns out that the protein enters cell nuclei, combines with another protein called dTCF, latches onto DNA and becomes the equivalent of a light switch. "Now that we understand what happens normally, we can i...Enzymes Targeted As Key To Understanding Drug Interactions
...ing systematic knowledge of how various enzymes -- biochemical catalysts produced by the body -- metabolize drugs. Their research is producing an understanding of the potential for adverse effects among thousands of drug combinations. "Pharmacists have had to remember hundreds of pairs of drugs that interact," ...Huntington's Disease Findings Pave Way For Potential Cure
...hanges with unprecedentedclarity. The cellular and biochemical mechanisms they have discovered could be astarting point for the development of new drugs that could interrupt theprogress of Huntington's disease or prevent it in people at risk. The gene for Huntington's disease (HD) was discovered in 1993 ...Scientists Discover How Genes Work Together To Control Neural Development
...n the process,they also discovered the first known biochemical function for the Phyllopodand Sina proteins. "Our test-tube experiments demonstrated that Sinaand Phyllopod bind to each other to form a partnership and that they alsobind to Tramtrack to form a triad," Carthew says. Using genetically engineered fl...Progress In Prion Research: Three-Dimensional Structure Of Prion Protein Fully Uncovered
...on diseases. They will beuseful in planning future biochemical and biomedical studies. Further information: Prof. Kurt Wüthrich, Institut für Molekularbiologie und Biophysik, ETH-Hönggerberg, 8093 Zürich Tel. +41 (0)1 633 24 73; Fax: +41 (0)1 633 11 51 Swiss National Science Foundation, M. Iten...Gene For Last Major Form Of Batten Disease Discovered
...ew Jersey,located the gene using a newly developed biochemical approach to identify theenzyme missing in the disease. The center is a joint program of the Universityof Medicine and Dentistry of New Jersey (UMDNJ) and Rutgers University. Thescientists then compared this enzyme to known proteins and gene segment...New Mechanism To Explain Carbon Monoxide Poisoning Identified
...Pennsylvania Medical Center have discovered anovel biochemical mechanism for carbon monoxide (CO) poisoning that ...," says Thom. Thisimbalance makes NO available for biochemical reactions that would not normallyoccur within the cell, namely ones that produce tissue-damaging oxi...Scientists Use IGF-I To Grow New Membranes Around Neurons
...F-I promotes myelination by triggering a series of biochemical changes which help Schwann cells move and attach to nerve fibers," Russell said.U-M scientists are currently testing IGF-I's ability to stimulate myelination and regenerate nerves in adult rats with neural damage, according to Feldman. "One major pr...Max-Planck Researchers Unravel The Structure Of The Methane Forming Enzyme
...s within the protein on an atomic ground. The biochemical reaction of methyl-coenzyme M reductase proceed... detailed enzymatic mechanism of such a complex biochemical reaction. Moreover, this structure can serve as reference point, to interprete more reliable b...UF Researcher Designs Pill To Control Mosquitoes
...mosquito-borne diseases," said Borovsky, an insect biochemical and molecular biologist at the Florida Medical Entomology Laboratory, a part of UF's Institute of Food and Agricultural Sciences. "It works on all mosquitoes, all over the world." In the mosquito control war, mosquitoes are winning. There are more th...Fruit Flies May Shed Light On Cocaine Addiction
...s. Because humans and fruit fliesuse many similar biochemical pathways, this discovery suggests that the fliesma...f normal flies, they hope toreveal the genetic and biochemical pathways involved in cocaine-induced behaviorand addiction. These insights may lead to better trea...DNA Enzyme Works In Crystal Form; Yields New Insights Into Gene Copying
... have taken snapshots that catch the enzyme in the biochemical act ofcopying DNA. Soon they will make movies. The scientists' images also arerevealing details of how cancer-causing chemicals interfere with the copyingprocess. The biochemists, led by assistant professor of biochemistry LorenaBeese, publi......include lecturer Stanley Tabor, who figuredout the biochemical conditions to enable crystallography, postdoctoral fellowSylvie Doublié, who produced the crystal structure, and Alexander Long, atechnician....Emory University Fragile X Group Receives NIH Program Grant
... genetic, molecular biological,neurobiological and biochemical approaches to the syndrome, including cellculture, transgenic mice and yeast systems to help uncover additional answers. The seven projects will be led by a diverse group of both establishedand newer Emory investigators, including Drs...B-Vitamins Lower Homocysteine Levels In The Blood; May Reduce Vessel Damage In Stroke Patients
...lls -- damage that canlead to strokes. The biochemical markers are homocysteine, a natural byproduct of thebody's metabolism of protein and other nutrients, and thrombomodulin, producedby the injured cells lining blood vessels. When these endothelial cells areinjured, blood clots can form. Thrombomodul...Plants Thrive With Insect-Induced Immune Responses
... wild radish plants wasevidenced by characteristic biochemical changes in the plant tissue. (Previousresearch in...as identified ahormone that appears to trigger the biochemical chain reaction that constitutesan immune response in plants. One product that makes use of this che...... Breslow, senior scientist at the laboratory of biochemical genetics andmetabolism and Frederick Henry Leonhardt Professor at Rockefeller University,New York, will speak about, "Induced Mutant Mouse Models of LipoproteinDisorders and Atherosclerosis." "As a species, the mouse is highly resistant to ather......hich has used that truth, along withthe results of biochemical studies with seaweed, to overturn a widely-heldpri... Their work demonstrates a heretofore unknown biochemical mechanism whichmakes organisms "exquisitely sensitive" to environmental cues such as watermotion and...