Researchers discover genetic basis of heritable sleep disorder
...ay. This internal clock controls a variety ofdaily biochemical and behavioral cycles -- including fluctuations in sleep andwakefulness -- that are collectively called circadian rhythms. People with FASPS have a "fast" biological clock -- their internal clock's"day" is shorter than 24 hours. If left unconstraine...Study identifies key molecular mechanism in cancer and rheumatoid arthritis
...of these proteins." The new findings are based on biochemical assays of cultured cells. Theresearchers show that after stimulation with growth factors, NF-kappaB becomesactivated through an intricate sequence of molecular signals --protein-to-protein relays -- involving Ras and Akt. The activation of NF-kappaB,......reakthrough inmemory research and reveals a common biochemical mechanism at the root of nearlyall learning. It shows that the brain uses the same basic tool when it formsassociations, even though parts of the brain work in specialized ways and dealwith diverse types of information, such as sights, sounds and tou...Fragment of AIDS virus may be used to deliver therapeutic proteins to cells
... the TAT fragment can penetrate a cell at all is a biochemical quirk, saysDowdy, which was first reported by researchers in 1988. As a result, it isunlikely that the HIV fragment poses any danger of triggering disease, hesaid. To demonstrate that the technique works, the HHMI team hooked the11-amino-acid TAT fr...Enzyme inhibitor reduces cardiac cell death in heart attack
...se inhibitor knownas YVAD-cmk not only blocks this biochemical cascade but also protects hearttissue, dramatically reducing the amount of myocardial death by over 30 percent. Vincent L. Cryns, M.D., and colleagues in the Feinberg CardiovascularResearch Institute at Northwestern published the results of a...Experiments illuminate workings of biological clocks
...ing fruit flies with light pulses andanalyzing the biochemical consequences, investigators from the Howard Hughes...ent work, theHHMI team was able to demonstrate the biochemical mechanism that reduces levelsof TIM, a key to clock synchrony. Light itself doesn't directly reset ...Researchers discover breast cancer gene inhibitor
... role in breast cancer that if you can inhibit its biochemical activity, you should be able to control the cancer," said Gail Clinton, Ph.D., associate professor of biochemistry and molecular biology at OHSU's School of Medicine. Clinton and her former student, Joni Doherty, M.D., Ph.D., discovered herstatin w...Warner-Lambert Company gift creates bioinformatics program
...tical modelscapable of characterizing thousands of biochemical variables simultaneously." A portion of the UMHS funding will be used to finish renovating a5,000-square-foot area, which will be equipped with advanced computer hardware,software and network support, according to Savageau and Allen S. Lichter, deano...Scientists identify novel component of cell-fate pathway
...lead toa better understanding of the molecular and biochemical details that controlcell fate and growth and may permit scientists to influence developmentalprocesses, like those that lead to cancer. The new component, casein kinase I (CKI), adds another step to thepreliminary outline of how the Wnt-signali...UCSC researchers obtain first detailed images of a complete ribosome
...o subunits," said Culver, whoperformed a series of biochemical studies to characterize the components of thebridge. "The x-ray crystallography and the biochemical experiments complemented eachother beautifully to provide these very clear results," Noller noted. T...Millennium and the Whitehead Institute identify novel protein important in fat absorption
...protein provides newinsight into the molecular and biochemical pathways involved in the transportand utilization of dietary fat," added Tartaglia. "Previously, our laboratory had identified a novel class of proteins calledFATPs, which are associated with fatty acid transport proteins," said Dr. HarveyF. Lodish ...Researchers discover hemoglobin's enzymatic nature
...fthis oxygen-hungry molecule by using a variety of biochemical techniques and bytaking physical measurements of t...nside the worm. In so doing,they have identified a biochemical link between the hemoglobins used byprimordial bacteria to detoxify themselves of atmospheric gases ...Researchers characterize mollusk insulin gene, find unique peptide
...dentified." By employing a combination of advanced biochemical and mass spectrometricmethods, Sweedler and colleagues at the U. of I., Columbia University and theMount Sinai School of Medicine in New York City successfully identified the geneand fully characterized its chemical structure. The researchers report...NIH grantee Günter Blobel wins Nobel Prize for protein signaling discovery
...rotein translocation in the cell. This allowed the biochemical dissection of the process, leading to a series ofkey discoveries in his laboratory. More recently, Dr. Blobel has studied the mechanisms governing the bidirectionaltraffic of proteins into and out of another membrane-bound cellular organelle,the nucl...Heart cells closely control their own oxygen supply
...ay be the disruption of thisfinely tuned system of biochemical crosstalk between heart cells and the vesselssupplying them with their needs. "This is a system that controls the coronary blood vessels so that the amount ofblood flow to the heart is just right," says Saul Winegrad, MD, a professor ofphysiology and...Argonne biochips may halt tuberculosis epidemic
...he biochips are designed to carry out thousands of biochemical reactionssimultaneously, and have performed well in laboratory tests. "But this will betheir first test in the realm of real-world medical diagnostics," said HarveyDrucker, Argonne associate director. "We chose tuberculosis for the tests," he said, ...Brain compound's anti-aggression effects appear to reverse in monogamous male rodents
...esearchers begin totease apart some of the complex biochemical roots of mating-related behaviors. "By focusing on these specialized behaviors, we're starting to pick up on someimportant similarities in the ways they may be triggered," says Stephen Gammie,a postdoctoral fellow in the Psychology Department at Hop...U-M scientist discover how viruses hide inside human cells
...n expressed by one gene on the virus that builds a biochemical docking station linking viral DNA to the chromosom...packed to form chromosomes. "The results suggest a biochemical mechanism which binds elements of viral DNA to host chromosomes through the interaction of LANA, his...Smells may trigger alcohol craving, and relapse, among alcoholics
...dency have demonstrated a common underlying set of biochemical mechanisms. Although different substances of abuse seem to act on different parts of the brain's neuronal circuitry, the result is the same: dopamine is released in the nucleus accumbens. Dopamine appears to be one of the primary neurotransmitters......ource of intermediates for the production of other biochemical compounds. One of the key enzymes in this process ...furt scientists may not only be relevant for basic biochemical research, but also for medical research. For instance, mutations of succinate dehydrogenases have be...