How an insidious mutation fools DNA replication
...ccurate and mutated strands from the template. The biochemists encountered a surprise when they analyzed the polymerase crystals with either the correct or mismatched nucleotides. "We saw that, ironically, when the polymerase binds the correct cytosine opposite 8-oxoguanine, the structure looked like DNA mispair...Humans march to a faster genetic 'drummer' than primates, UC Riverside research says
A team of biochemists from UC Riverside published a paper in the June 11 issue of the Journal of Molecular Biology that gives one explanation for why humans and primates are so closely related genetically, but so clearly different biologically and intellectually. It is a...Scientists visualise cellular handmaiden that restores shape to proteins
...ately, the largest users of this new knowledge are biochemists working on the protein and bioinformaticians, searching for similar molecules in other species. Human mitochondria likely use the same type of chaperonin to fold proteins says Professor Iwata. In time their structure may be used in the development of...Protein engineered to detect nerve gas
DURHAM, N.C. -- Duke University Medical Center biochemists have used computational design to engineer and con... molecule. Once the designs are narrowed down, the biochemists construct the proteins and test them for selectivity and binding properties. "We chose PMPA because ...Wisconsin chemists find a new chink in TB's armor
...ural & Molecular Biology by a team of chemists and biochemists from the University of Wisconsin-Madison, opens the door to the development of a new family of antibiotics to treat diseases that still claim as many as 3 million lives annually worldwide. "Most of the treatments we have for these diseases date from ...Decoding a sulfate-breathing bug
...ys that having the genome of D. vulgaris will help biochemists determine exactly how the microbe corrodes iron and perhaps develop better ways to prevent that damage. "Understanding how sulfate-reducing bacteria use substrates to make energy and how they position themselves in the environment is fundamental to e...How DNA copying enzyme 'stops the presses' for repair synthesizing enzyme
...f the journal Cell, Duke University Medical Center biochemists Sean Johnson and Lorena Beese, Ph.D., described ho...rystal," said Beese. Using this approach, the Duke biochemists engineered the polymerase to be error-prone, so that they could produce crystals with mispaired base...Researchers describe new technique for cataloging RNA targets in rare brain disease
...ed a pair of standard techniques in the arsenal of biochemists -- photo cross-linking and immunoprecipitation -- with the use of brain tissue and a number of special techniques to create a new method called CLIP. CLIP works by exposing cells to ultraviolet (UV) light, which causes very strong chemical bonds -- ...UCSD researchers find promising new avenues for treating infections
A study by University of California, San Diego biochemists explains why infections of Pseudomonas bacteria, which affect 200,000 hospitalized patients each year in the United States, can be so dangerous to cells within the body, and points to new ways to treat those infections. Pseudomonas aeruginosa, a com...Missing link detected in insulin mechanism
...ifaceted insulin pathway, Dartmouth Medical School biochemists have found a missing link that may spark the connection for glucose to move into cells. The discovery is another strand in the remarkable web of molecular signals that regulate traffic through cells and helps elucidate crucial aspects of how the hor...Clue to prion formation found, offers step toward treating puzzling diseases
...the spread of infections. Dartmouth Medical School biochemists studying the mysteries of these prion particles have discovered a novel step in their formation. Their results, reported in a recent issue of Biochemistry could help provide a new approach for therapy against prion diseases. The team, headed by Dr....Engineered proteins will lead to 'synthetic biology'
DURHAM, N.C. -- Duke University Medical Center biochemists have developed a computational method to design pr...e hundredth power possibilities. However, the Duke biochemists have enhanced and applied a mathematical technique called dead end elimination -- pioneered by mathe...Biology breakthrough could aid understanding of cancer
..., to be published Friday in the journal Science by biochemists from Oregon State University and Wake Forest University, may also help resolve a significant debate in the science community about the role of hydrogen peroxide in cellular signaling and control of life processes. This chemical would be recognize...WWII discovery may counter bioterrorists
...as secretly developed more than six decades ago by biochemists at Oxford University and is still stocked in many ...s noted in their article. "Little did those Oxford biochemists working on the antidote to a greatly feared chemical warfare agent realize that BAL would still be n...Blasting antibodies with lasers provides direct way of measuring their flexibilities
...hanical techniques. Shaken Not Stirred For years biochemists have routinely used bench top ultraviolet and visible light spectrometers to measure things like protein concentration or to follow chemical reactions. However, Romesberg's spectrometer is not the kind you might find in any catalog of equipment lying...Photosynthesis analysis shows work of ancient genetic engineering
...ution of complex life. After decades of research, biochemists now understand that this critical biological process depends on some very elaborate and rapid chemistry involving a series of enormously large and complex molecules a set of complex molecular systems all working together. "We know that the process ...Researchers elucidate machinery of major anti-cancer target
DURHAM, N.C. -- Duke University Medical Center biochemists have reported the detailed function of an enzyme t...s. In an article in the October 10, 2002, Nature, biochemists Lorena Beese, Patrick Casey and Stephen Long reported detailed X-ray crystallographic studies of FTa...Pinpointing the protein problem in Lou Gehrigs Disease
...isease instead of a death sentence. The Rensselaer biochemists vital research has recently earned a $1 million, four-year grant from the National Institutes of Health. The NIH grant will support Colons study of the hereditary version of the disease, called familial ALS or FALS. He is attempting to understand why...Wheat may be vital in battle against cancer and other diseases
...e plant's orthophenols. Takemoto and other K-State biochemists are in the early stages of developing wheat with high levels of orthophenols. A successful modification could lead to wheat's ability to combat cancer by simply including it in a daily diet. K-State scientists are optimistic of wheat's cancer-fightin......d to come together. Now, Dartmouth Medical School biochemists have devised a high tech way to watch, in living color, how these bubbles fuse, and what they have seen upends prior assumptions about the ways cell components transfer chemical information. Their findings, published in the February 8 issue of the ...