Scientists report on promising new approaches to induce cancer cell suicide
... using a synthetic fragment of genetic material to block production of a protein that many tumor types use to survive. Researchers at Eli Lilly and Company reported the studies of the compound, LY2181308, which is directed against a molecular target called survivin. Survivin belongs to a family of protei...Small-molecule inhibitors of botulinum neurotoxin identified
...entists have identified several key molecules that block the activity of a toxin that causes botulism--an important first step in developing therapeutics to counter the disease. Botulinum neurotoxins (BoNT) are useful as therapeutic agents for treating a wide variety of muscle dysfunctions in humans, and a...Worlds largest scientific society holds regional meeting in Atlanta
...ethanol and mercaptans to formaldehyde, a building block chemical used for thermosetting adhesive resins which are used to bond plywood and other wood products. The waste gases are processed through a plant, which is similar in design to a conventional formaldehyde plant that utilizes commercial-grade meth...Investigational cancer drug prevents abnormal brain growth, reverses seizures in lab mice
...led the dentate gyrus. Because CCI-779 is known to block mTor activity, this finding was strong evidence that mTor was driving the abnormal growth, since blocking mTor with CCI-779 prevented it. The team also showed that the ability of cells in different parts of the brain to respond to the drug depended ...Genetics mutations resulting in delayed puberty are focus of MCG study
...l in infertility treatment as well. You also could block them and make a contraceptive. So there are a lot of possibilities." Dr. Layman recently received a $1 million grant from the National Institutes of Health, the second NIH grant he has to tackle the laborious task of studying the some 100 genes beli...Golfing toward a greener environment
...pollutants into the ground. Tire chips' ability to block these pollutants led Park, civil and environmental engineering graduate student Bob Lisi, and horticulture professor John Stier to consider another application: placing ground-up rubber beneath chemically treated golf-course greens. Park says just ...Researchers find role RNA plays in progress of Alzheimer's disease
...of Alzheimer's," he said. "Then, if we can somehow block that process, perhaps we could reduce the progression of the disease."...New technique helps shed light on progression of dementia
...cted into rats tiny microspheres small beads that block blood flow into the main artery that feeds brain tissue. The researchers wanted to mimic what happens in the brain during a small stroke. These small beads ultimately lodged in the tapering ends of blood vessels, where they stopped blood flow. It's ...Diet may improve cognition, slow aging, and help protect against cosmic radiation
... exposure to environmental chemicals that mimic or block the action of the sex hormones estrogen and testosterone may disrupt normal differences in the brain between males and females -- differences that affect thinking and learning as well as sexual behavior. These findings add more scientific support to ...British Antarctic Survey wins environment award
... waste including hundreds of fuel drums, an engine block and general rubbish was removed. Hazardous wastes such as lead-acid batteries, medical syringes and asbestos were also cleared away. The wastes were first flown to Rothera Research Station and then shipped to the Falklands Islands or UK for recycling...Anti-platelet drug blocks bone metastases in mice
...ments, scientists had hoped the drug, ML464, would block the spread of a melanoma cell line into bones. The... surprised to find that not only did the treatment block bone metastases, it also reduced the development of new tumors in organs like the liver, intestines ...Breast cancer can be reversed in laboratory mice, scientists report
...nstrated for the first time that it is possible to block genetic switches in mice that turn cancer on and o... and the challenge is to develop an agent that can block its activity," said William J. Muller, professor of biochemistry at McGill University in Montreal an...Researchers determine a contributing genetic factor of photosensitivity in lupus patients
...screens that will hopefully improve the ability to block the harmful effects of sunlight. Funding for this research was provided by the Lupus Research Institute through their Novel Research Program, which seeks to support highly promising novel approaches to discover the cause, improve the treatment and cu...FDA approves Raptiva (efalizumab) for chronic moderate-to-severe plaque psoriasis
...ic antibody designed to selectively and reversibly block the activation, reactivation and trafficking of T-cells that lead to the development of psoriasis symptoms. In clinical studies, RAPTIVA demonstrated a rapid onset of action in the reduction of symptoms associated with psoriasis, in some patients wit...Biological trick reveals key step in melatonin's regulation
.... For AANAT, the key spot turns out to be building block number 31, the researchers have found. "We have di...heng, Ph.D., developed a mimic of the key building block with the equivalent of a permanently affixed phosphate group. Zheng inserted the mimic into the app...JAK2 enzyme helps protect brain cells, wreaks havoc on blood vessels
...or angiotensin converting enzyme, inhibitors which block angiotensin II production. ACE inhibitors are wid...n," says Dr. Marrero. "And how does angiotensin II block that action via JAK2? It may even be that JAK2 plays a role when angiotensin II acts as a growth fac...Common genetic damages in non-dividing cells lead to the creation of mutant proteins
...already have learned that some genetic damages may block the transcription process, which is a signal for DNA repair molecules to move in and correct the mistake. When the DNA repair machinery is defective, however, the non-dividing cells are capable of continuing transcription despite the erroneous codin...Embryonic pathway critical to growth of digestive tract tumors
...lant-derived chemical called cyclopamine, known to block Hedgehog, killed these cancers when grown in mice, causing no apparent harm to the animals. "In mice, blocking the Hedgehog signal made the implanted tumors disappear," says the study's first author, David Berman, M.D., Ph.D., assistant professor of...Hopkins researchers discover how nitric oxide prevents blood vessel inflammation
...growth and erections - have figured out how it can block blood vessel inflammation and prevent clotting, a ...e led Lowenstein's team to develop a novel drug to block exocytosis, thereby acting as an anti-clotting agent. It is a peptide that blocks exocytosis by a m......Bernstein. Among many discoveries, conotoxins that block key neurological pathways have been effective in the early detection and may also help treat small-cell lung cancer, one of the most devastating human cancers. A compound now in clinical trials has powerful anti-epileptic activity. Experiments sugges...