Essential smell gene may provide key to new insect repellents
... for developing insect repellents. Repellents that block the gene, and thus prevent disease-carrying insects from finding human hosts, might eventually help fight malaria and other infectious diseases. "This finding has a direct applied potential," says assistant professor Leslie B. Vosshall, Ph.D., head o...... cell culture and in live animals, that they could block growth of already transformed skin cells if they inhibited Stat3 function using an oligonucleotide inhibitor. Additionally, when skin tumors were injected with this Stat3 functional inhibitor, tumor growth itself was impaired. This study provides ...JCI table of contents: 1 September, 2004
... cell culture and in live animals, that they could block growth of already transformed skin cells if they inhibited Stat3 function using an oligonucleotide inhibitor. Additionally, when skin tumors were injected with this Stat3 functional inhibitor, tumor growth itself was impaired. This study provides t...Anti-cancer compound in vegetables found to block late-stage breast-cancer cell growth
...aturally occurring plant chemical sulforaphane can block late stages of the cancer process by disrupting co... were surprised and pleased to find that SUL could block the growth of breast cells that were already cancerous." SUL is abundant in such vegetables as brocc...The future of HIV therapeutics is brightening, according to Gladstone Institutes Director
...irely new class of anti-HIV drugs. New agents that block the first step in HIV's life cycle, the entry of t...tunity for future drug development. The goal is to block the assembly or ensuing action of Vif on APOBEC3G, thereby preserving intracellular expression of AP...Highlights of American Chemical Society national meeting in Philadelphia, Aug. 22-26
...n-peptidic compounds inhibit the measles virus and block the virus from entering cells. Although further testing is needed, the researchers hope that the development will ultimately save lives. ( MEDI 333 , Thursday, Aug. 26, 11:30 a.m., Pennsylvania Convention Center, Room 204A. Also part of Sci-Mix on Mo...Strep disrupts blood clotting to infect humans
...cal bacteria use an enzyme called streptokinase to block the blood clotting response and allow themselves to move more freely around the human host's circulatory system. The molecule is so specific, it only works on humans, not on other animals. "The theory is that, as bacteria cause a local infection an...University of Pittsburgh receives $10 million grant for head and neck cancer
...ary studies suggest that combining strategies that block both receptor families has a synergistic effect on inhibiting the growth of head and neck cancer cells. With 36,200 estimated new cases and 11,000 deaths in 2003, head and neck cancer accounts for 4 percent to 5 percent of all newly diagnosed cancers...Tiny molecules have big potential as cancer drugs, Stanford researcher believes
...uestion is what are they doing and does it help to block them?" To find out, Bogyo and colleagues used fluorescent tags to track cathepsin activity in mouse models of two types of cancer. They found the cathepsins helped build blood vessels to the tumors as well as increase tumor growth and invasiveness. T...Nevada researcher re-ignites mammal reproduction debate
...pulations of wild mammals. An injected steroid can block glucose circulation, and potentially increase the number of female offspring, while in the long term the same result may be accomplished through diet. Such a study would be able to show whether mammal populations in different regions could be increa...Penn scientists identify novel pathway in aneurysms
... this inflammation pathway," says Funk. Drugs that block the formation and action of this pathway are currently used to treat inflammation in the airways of asthmatics. "Perhaps they may become useful to treat patients who are susceptible to developing aortic aneurysms by blocking their progression and eve...Plumbing trees' plumbing reveals their engineering skill
... mechanical stress or drought induces bubbles that block water flow. The researchers found that trees adjust their root anatomy very effectively to work in different environments. Shallow roots and especially stems have thicker walls and smaller interior diameters because they must support the tree more, a...Study suggests cell-cycle triggers might be cancer drug targets
...ised the prospect of cancer therapy using drugs to block D1 and other cyclins. "Now we think it should be safe to target the cyclins with drugs that would be designed specifically to inhibit them," Sicinski says....Heartless worms hold clues to cardiac arrhythmias, sudden death
...elopment of drugs that don't cause calcium channel block The worm C. elegans seems an unlikely candidate ...event arrhythmias and sudden death associated with block of a potassium channel called HERG (Human ether-a-go-go related gene). Many therapeutic drugs -- an...New mechanism for display of foreign proteins to immune system
...through their counter-surveillance mechanisms that block only one of these pathways."...X marks the spot: Vector insertion is viral specific
...d how HIV enters cells in order to devise drugs to block that entry. "If there's a key interaction required for growth of a virus, then that would be a target to inhibit," says Bushman. HIV needs three enzymes - reverse transcriptase, protease, and integrase - to complete a full replication cycle. AZT and ...ASU researchers demonstrate new technique that improves the power of atomic force micrscopy
...loor, but it can't tell the difference between one block and another," Lindsay explained. "What we have done, is allow the person sitting on the floor and feeling those blocks to open their eyes and see that there are red Lego blocks, green Lego blocks and yellow Lego blocks." "This allows you to identify ...Joslin Diabetes Center launches research section on developmental and stem cell biology
... of birth defects through dietary supplements that block oxidative stress. In addition, excess glucose metabolism may impair expression of many genes that contribute to the progression of diabetic complications in general, thus her research using the early embryo and embryonic stem cells may lead to new tr...Bad news for pathogenic bacteria: Scientists find protein essential for bacterial survival
...to environmental signals. Figuring out how to block DksA production in harmful bacteria may help scientists develop antibiotics that these bacteria are less likely to resist, said Irina Artsimovitch, a study co-author and an assistant professor of microbiology at Ohio State University. The current ......nal genetic models may be discovered that mimic or block behaviors associated with cocaine addiction, the striking concordant neurochemical phenotype between Homer2 deletion and withdrawal from chronic cocaine treatment indicates that Homer is a particularly good candidate to play a central role in cocaine...