Outcome for acute lymphoblastic leukemia linked to gene expression patterns
...e is no universal cross-resistance gene that would block sensitivity to all four drugs. Rather, genes linked to resistance belonged to different functional categories (i.e., they did different tasks in the cell) and these differed for each medication. "Learning the function of these gene...Genetic discovery could dramatically reduce need for liver transplants in children
...ouse model to develop new treatments to ultimately block obstruction of bile ducts in children who have biliary atresia. "The long-term goal is to stop progression of disease at the time of diagnosis and increase the chances of long-term survival with the native liver," he said....Two-pronged attack targeting EGF receptor hinders cancer cell growth
...late proteins inside the cell. Iressa or Erlotinib block the EGFR kinases from adding phosphate groups to other proteins within the cell. Used together, the monoclonal antibody and either of the small molecule kinase inhibitors amplified control of cancer cell growth and signaling. With the reduced EGFR-...New UCF researchers, college will help fight Alzheimer's disease, cancer
...enter before coming to UCF, is researching ways to block the toxins that cause cholera, dysentery and other...a and other health problems. Learning how to best block that movement can help produce better drugs to fight those diseases, which are common in Third World...Firefly compound lights up 'protein dance' in living animals
...e cycle. An anti-cancer drug is being developed to block the interaction of these proteins. "We can now monitor the effects of that drug in live animals using the luciferase technique," says Piwnica-Worms. "It's been an exciting development we're already collaborating with several colleagues around campus...UCI study reveals gene linked to breast cancer can suppress tumors
...e BRCA1 gene is mutated, however, it can no longer block this signaling activity from stimulating the growt...ells. The findings suggest that drugs developed to block estrogen signaling at these specific pathways can help curb the incidence of breast cancer in women....Study yields insights into precancerous condition
...wly transplanted organs from being rejected] could block mTOR," says Cantley. "These new results suggest that the use of mTOR inhibitors, including rapamycin analogs currently being tested in clinical trials for the treatment of cancers and tuberous sclerosis, may be useful for the treatment of polyps aris...NRH1 and Wnt signaling come together in convergent extension
...g with NRH1 function by introducing morpholinos to block production of the NRH1 protein had similar effects the inhibition of convergent extension. That both gain and loss of NRH1 function resulted in the failure of CE activity suggested that the gene's function in this process is tightly regulated. Thes...New textbook introduces students to the foundations, applications of nanotechnology
...ar to the work of a sculptor carving a face from a block of marble." On the other hand, the bottom-up approach is the assembly of individual atoms and molecules to form complex systems. The second section of the textbook looks at the new materials that have become the building blocks of nanotechnology th......ompleted. The reversible nature of the infertility block caused by loss of the Pde3a gene suggests that PDE3A may be a potential target for developing new contraceptives. The Pde3a knockout mouse will be an excellent model of female infertility for exploring this further....JCI Table of Contents, 15 July 2004
...he apparently reversible nature of the infertility block caused by innactivation of the Pde3a gene suggests that PDE3A may be a potential target for developing new contraceptives. The Pde3a knockout mouse will be an excellent model of female infertility for exploring this further. TITLE: Cyclic nucleotide ...Protective mechanism exploited by tumors may provide new cancer treatment
...tem. They also found that when they gave a drug to block IDO expression, the immune system rallied. "Our hypothesis in this situation was that the bad guys in this case were actually cells from the host, perfectly normal cells that had, in a sense, been requested by the tumor," says Dr. David Munn, pediatr...Acamprosate: potential medication for treating alcoholism
...receptors to which they bind. Naltrexone can also block alcohol craving (especially the type of craving generated by people, places and things associated with alcohol) and reduce alcohol consumption, leading to less relapse drinking and more abstinent days. Although it is well tolerated and does not prod...Cell death protein has surprising role in cell migration
...scientists have discovered that a protein known to block cell death also has the completely independent rol...ng cell death, but from its ability to bind to and block enzymes called caspases that chew up a variety of proteins. By doing so, IAP prevents the destructio...Argonne scientists determine structure of staph, anthrax enzyme
...ld be a good target for a drug, because if one can block the enzyme, it will not be able to attach these proteins to the surface and the bacteria would not be able to get iron from our bloodstream," Joachimiak said. The research looks at sortase from both staph and anthrax more formally, Staphylococcus au...Vioxx in high doses causes hypertension
... don't irritate the stomach as much as NSAIDs that block both enzymes. "They cause fewer ulcers," explained the study's lead author, Marie R. Griffin, M.D., MPH, professor of Preventive Medicine and Medicine. "That's a good thing in many ways, although there's a lot of people using them who are pretty low ...When sun's too strong, plankton make clouds
...ry that plankton can indirectly create clouds that block some of the Sun's harmful rays. The study was conducted by Dierdre Toole of the Woods Hole Oceanographic Institution (WHOI) and David Siegel of the University of California, Santa Barbara (UCSB). The study finds that in summer when the Sun beats dow...XsalF comes to the fore in brain regionalization
...njecting morpholinos (short nucleotide chains that block the function of a targeted gene), which gave similar results to the earlier loss-of-function studies. These preliminary findings prompted the lab to look into the molecular mechanisms behind XsalF's anterior specifying activity, which they suspect...Gene therapy alternative to calcium channel blockers
...ease, but they can cause low blood pressure, heart block and constipation," said study lead author and cardiovascular physiologist Eduardo Marbn, M.D., Ph.D., professor and chief of cardiology at The Johns Hopkins University School of Medicine. Marbn is also director of the Hopkins Institute of Molecular ...Mitochondria in spinal cords is ALS target according to UCSD medical researchers
...rt of our continuing work as we seek components to block the toxicity of SOD1 and find ways to slow the damage that occurs in ALS."...