Animal research suggests plant estrogens in soy do not increase breast cancer risk
...ave estrogen receptors, such as breast tissue, and block the effects of the other types of estrogen. Isofla...olleagues are currently looking at whether soy may block breast cell proliferation induced by estrogen therapy....Study supports association between HPV infection and head and neck cancer
...in host cells may allow us to design strategies to block malignant transformation," they write. "The promising results from a trial of an HPV vaccine to prevent cervical cancer raises hope that such a strategy can also be used to reduce the incidence of HNSCC."...Protein controls acid in cells by direct detection of volume changes, study finds
...en done (on inhibiting NHE1) has shown that if you block this transporter, you can prevent this type of cell death from ischemia." Previous studies have suggested that NHE1 plays a role in cancer cells that are trying to spread, or metastasize, to different parts of the body. As cancer cells move, they mus...JCI table of contents, 1 July 2004
...rray technology and as well as other mechanisms to block PPAR gene family action. In doing so, they were able to dissect specific roles for different members of the PPAR gene family in different tissues. Specifically, their data here show a direct role for PPAR_lpha in the metabolism of glycerol metabolism...Cancer gene MYC emerging as key research target
...kings in an effort to develop therapies that would block MYC's function in cancer. The promise of therapies... MYC, but current efforts involve drugs that would block all MYC function. Understanding the specific targets of MYC and their involvement in cancer should u...Gene alteration points to longevity, thinness
...fat and cholesterol. "If you find a drug which can block the function of this transporter, it might interfere with the use of citrate for fat and cholesterol synthesis which should help people lose weight and reduce their cholesterol," Dr. Ganapathy says. Drs. Fei and Ganapathy also are working to identify...New milestones on the path to conquering HIV drug resistance (AIDS)
...ite near the heart of the RT molecular machine and block its activity. "It's like throwing a molecular monkey wrench into the virus's essential machinery," Arnold said. The success of the compounds may be due to their ability to assume different shapes, allowing them to adapt to the changing shapes found i...'Mighty mouse' gene works the same way in people
... a great deal of hope that agents already known to block myostatin activity in mice may be able to increase muscle mass in humans, too." Lee and his team discovered in 1997 that knocking out the myostatin gene led to mice that were twice as muscular as their normal siblings, lending them the moniker "migh...Jefferson researchers develop microchip to track genetic signature of cancer and normal tissue
...pression. They either degrade the messenger RNA or block its translation. Cells in organisms from yeast to mammals make interfering RNA to shut off gene expression in development. Dr. Croce and his colleagues had previously shown that deletions in miRNA genes were involved in B-cell chronic lymphocytic leu...New study confirms process leading to disorder causing male characteristics in women
...nist (ganirelix, 2 mg subcutaneously) was given to block endogenous LH secretion, followed by dexamethasone (0.75 mg orally) to suppress adrenal androgen secretion. Twelve hours after ganirelix injection, intravenous infusions of recombinant human LH were administered at four-hour intervals with the highes...Flies may taste bitter better, first map of insect 'tongue' reveals
...ein said. For example, compounds that specifically block proteins underlying insects' feeding response or trigger an avoidance response might offer targeted repellants for human and agricultural uses, he added. Collaborators on the research include Natasha Thorne, Caroline Chromey and Steve Bray, all of Du...Molecule that 'blocks' key bacterial enzyme may lead to new antibiotics
...ural molecule that acts like a cork in a bottle to block a key bacterial enzyme potentially leading to a new generation of antibiotics. Two teams of researchers at Rutgers, The State University of New Jersey, discovered independently that MccJ25 uniquely blocks a "tunnel" into the bacterial enzy...JCI table of contents, 15 June 2004
...including cellular proliferation and mechanisms to block cell death. It is already known that about one half of all liver cancers show a decrease or loss of expression of the PTEN gene. Surprisingly, however, Akira Suzuki and collaborators, from Akita University, now report a new role for this tumor suppr...Existing drug may prevent brain injury and seizures in newborns
... studies, they investigated whether compounds that block a certain type of glutamate receptor, known as AMPA, can dampen the harmful effects of excitotoxicity in the immature brain. The first study, published in the May 5 issue of The Journal of Neuroscience, examined a type of brain damage called peri...Genetic modification in mice lowers cholesterol and homocysteine by half
...er makes phosphatidylcholine(PC), the key building block of cell membranes in humans and other animals - and an important component of the HDL and LDL lipoproteins that carry fat and cholesterol in the blood stream. The CT pathway contributes about 70 percent of the PC in the liver and the PEMT pathway ...Yale researchers discover new potential asthma therapeutic targets related to parasites and insects
...e involved in inflammation. "We found that if we block the AMCase protein with an antibody or if we use an inhibitor that prevents it from digesting chitin, we can decrease asthma-like inflammation," said senior author Jack A. Elias, M.D., the Waldemar Von Zedtwitz Professor of Medicine and Section Chief...Gene expression ratio identifies risk of recurrence in breast cancer patients receiving tamoxifen
...ance the aromatase inhibitors that more completely block estrogen's action." Sgroi is an associate professor of Pathology at Harvard Medical School. The hormone estrogen can stimulate both the normal growth of breast tissue and the uncontrolled growth of breast cancer. Cells from most breast tumors conta...When blood can't get to brain, special CT scan helps
... to keep it going. But some medical conditions can block or reduce that life-giving flow. Whether it's a stroke, a clogged artery or a brain tumor, any situation where blood can't get to the whole brain can lead to death or permanent disability. And it's often hard for doctors to tell just where blood is -...UNC scientists block cellular enzyme activity involved in cancer progression
... as to how FAK works, then we can determine how to block its activity," Schaller said. "And if we do that, then we might be able to apply what we learn therapeutically against cancer." To better understand FAK activity, Schaller collaborated with the Structural Bioinformatics Core Facility at UNC to predic...Cell growth and death controlled by single pathway in lymphoma cancer model
...n jam the p53 suicide pathway, we might be able to block specific sections of those pathways," says the lea...nd that three of the five genes have been shown to block the function of the p53 protein. "That surprised us," says Stoffel. "We began to think that maybe t...