Tag: "block" at biology news

Clemson researcher receives Komen grant

...le to bind specifically to breast cancer cells and block the effect of PRL, inhibiting tumor growth in mice. What's more, the PRL antagonist has synergistic effects with the breast cancer drug Herceptin, which has only 30 percent response rate. Chen will use the Komen Foundation funding to further establis...

Mutant biological machine makes proteins but can't let go

... instructions are read, the right protein building block is added onto a growing chain, and at the appropri...ion, simply by properly orienting the new building block and the chain, an idea they are testing now. For the current study, graduate student Elaine Youngman...

Antibiotics alter GI tract microbes and increase lung sensitivity to allergens

... body for these antigens. These regulatory T cells block the development of allergic T cell responses in the lungs and sinuses." Most of the time, in ways scientists don't completely understand, the GI tract immune system modulates or dampens down the allergic T cells' response to incoming allergens in the...

Molecular image of genotoxin reveals how bacteria damage human DNA

...matic patch," and a dangling protein tail that can block a key portion of the CdtB subunit that is necessary for DNA cleavage. "We're not sure what the role of the cleavage-blocking protein tail is, but the structure helps us to understand how to interact with the active site of CdtB to impair its activity...

Gene at root of urban air pollution's lung effects

... mice be corroborated in human studies, drugs that block the function of the gene might serve as useful treatments for patients with asthma, the researchers said. The new study adds to earlier work highlighting the importance of genetic factors in determining the lung's response to environmental toxins by ...

Can we restore wetlands and leave the mosquitoes out?

...virus season has already begun. "Several obstacles block people from frankly discussing mosquito problems," writes Willott in her paper "Restoring Nature, Without Mosquitoes?" The article will be published in the June issue of Restoration Ecology. The short-term nature of funding is one problem. Another is...

Are bacteria turning our own weapons against us?

... immune systems a way to identify the bacteria and block the activity of these weapons." The gene in question makes a blood protein called alpha-2-macroglobulin, or α2m. This protein and its relatives have been studied in many different animals, and all have a similar function: defending the organism...

Researchers identify gene linked to sperm-producing stem cells in mammals

...yers then maybe we could develop a drug that could block the decision to become sperm a contraceptive that would be reversible." However, Braun stressed that such products are many, many years away and will require considerable research. Researchers also hope to someday be able to reverse the developmenta...

HIV takes cellular opportunities to aid infection

...wever, cocktails that contain chemical agents that block various steps of viral replication have allowed millions of people to survive with the disease. "This work could provide us with another class of molecules to add to the cocktail," said Young. "Once we identify cellular factors that regulate HIV rep...

Stem cells more vulnerable to toxic chemotherapy when protective molecule is disabled

...lls to carry oxygen to tissues. The basic building block of heme is porphyrin, which is toxic to cells when... Researchers elsewhere are developing molecules to block BCRP in leukemic cells in order to make them more vulnerable to chemotherapy. However, drugs that bl...

When 'reaper' gene comes, cell death follows

...id had to be inactivated before Yin saw a complete block in cell death, leading to the conclusion that both genes are required for efficient larval tissue cell death....

Landmark, pivotal Phase IIb/III trial of biotoxin for cancer pain begins

...ouver-based International Wex Technologies Inc. to block slow sodium channel nocicipetive pain fibers in a highly selective manner. Results from a recently completed open-label Phase IIa dose were presented in a podium presentation by the lead investigator, Dr. Neil Hagen, during the 2nd Joint Scientific M...

Botulinum toxin structure offers clues for vaccines/treatments

...nown varieties of botulinum toxin, types A-G. They block the release of neurotransmitters, the chemical messengers nerve cells use to communicate with one another and with muscles, by cleaving one of three proteins needed to release these chemical messengers. The Brookhaven team's work deciphering the stru...

Ritalin may improve Parkinson's symptoms, OHSU study says

...nhibitor, or SSRI, a class of antidepressants that block the reabsorption of another neurotransmitter, sero...panies already are looking at other drugs that may block the transporter, Nutt added. And the OHSU Parkinson Center will continue to study Ritalin, including...

Could vitamins raise levels of bad cholesterol? Animal study suggests they might

...hanges that made cholesterol form plaques that can block blood flow through the arteries. Although some subsequent clinical studies seemed to back up these findings, others did not. The new study by Dr. Fisher and his colleagues provides a different perspective on antioxidants. Surprisingly, his g...

Kinase backgrounder: Iressa discovery part of major kinase project at Dana-Farber

... companies can then select specific compounds that block these triggers, turning off the cells' stimulus to...to begin clinical trials of an inhibitor (drug) to block it. Gleevec, formerly known as STI-571, had been developed by Ciba-Geigy Corp. in Switzerland as one...

Discovery helps explain how cells package DNA

...search might therefore help lead to drugs that can block this process and lead to new cancer therapies. The biochemical pathways that cells use to package DNA in the nucleus remain poorly understood. In 1996, Parthun discovered an enzyme complex in yeast that cells use to assemble histones. He found that t...

Study identifies which patients can benefit from targeted lung cancer drug and why

... tyrosine kinases. The hope is that drugs known to block such proteins can stymie cancer growth while leaving normal cells intact. The study will be published this week in the online version of the journal Science ( www.sciencemag.org ). Related research from Massachusetts General Hospital Cancer Center, ...

UCLA chemists develop new coating for nanoscale probes

... and bacteria cells evolved unique capabilities to block toxic heavy-metal ions as a strategy to clean up the toxic environment in which they grow. These organisms synthesize peptides, called phytochelatins, that reduce the amount of toxic-free ions by strongly binding to inorganic nanoparticles made of th...

Newly discovered gene controls levels of 'bad' cholesterol in mice

...age to the blood vessels and leading to clots that block the follow of blood to the heart muscle. Maxwell's cholesterol study in mice is highly relevant to humans because mutant forms of the Pcsk9 gene have been linked to one form of autosomal dominant hypercholesterolemia, a group of genetic disorders cha...

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