Tag: "block" at biology news
Hopkins scientists overcome main obstacle to making tons of short, drug-like proteins
...tificial amino acids, as long as the fake building block
is tied to transfer RNA that the ribosome can use to "decode" genetic information. "There are a number of steps to the process of building peptides, natural or not, and each one has created problems for building large libraries of random drug-like pe...
Making a friendlier mosquito
...dvantage to mosquitoes that already carry genes to block
malaria, so that those genes spread through the population by natural selection. The genetic engineering work involved is challenging but should be possible, Hahn said. The work is published in the April 6 issue of the journal Current Biology....
...hy functioning and could return to normal once the block
was removed, as opposed to those that had permanent damage. While todays' methods give estimates of kidney function in percentages, tomorrow's doctors, using this painless, non-invasive MRI technique, may be able to pinpoint exact...
Surprises found in gene variation associated with schizophrenia
...ctions. If we can modulate them, we may be able to block
the ill effects of this gene and keep the beneficial aspects," Philibert said. HOPA stands for Human Opposite Paired Element. It was first isolated in 1994, when Philibert worked at the NIH. "There are at least 25 genes in the gene c...
Jefferson scientists use gene therapy to restore function of damaged heart cells in lab
...ovirus that encoded both ARKct a peptide that can block
ARK and a so-called "reporter gene" protein, which glows green. The latter provided a signal to the scientists that the inhibitor was indeed present in the heart cells. They then were able to use a video camera to actually measure how strong the ind...
Bim notes in the neuronal executioner's song
...stream activators of Bim or using Bim antisense to block
Bim expression reduced neuronal damage. Of interest, in the hippocampus of epileptic patients, Bim appeared to be selectively down-regulated. These results suggest a means by which the brain may protect itself from additional neural damage followin...
JCI table of contents, 2 April 2004
...stream activators of Bim or using Bim antisense to block
Bim expression reduced neuronal damage. Of intere...desirable form of vaccination given its ability to block
pathogens at their point of entry. The details of the mechanisms through which TCI triggers such a r...
Creating polymers that act like biomolecules
...d DNA react in nature. Unlocking how these soluble block
polymers are able to self-assemble could potential...and one hydrophobic block. Because the hydrophobic block
tries to avoid water, it forms the center of the string, with the hydrophilic next and the cationic ...
UIC researchers discover gene that causes liver cancer in animals
...sts also created a prototype for a drug that would block
Foxm1b activity and starve tumor cells of the protein that Foxm1b manufactures, preventing their multiplication. The potential drug was a variant of a protein known to suppress tumors, called p19ARF. By attaching a string of arginines, a component of...
World's largest tiger reserve declared in Myanmar
...nt between 1996 and 2002. This 12,000 square-mile block
now stands as one of the largest forested protected areas in Asia. The Wildlife Conservation Society's efforts to save tigers throughout their range are featured in "Tiger Mountain," a new exhibit that opened at the Bronx Zoo last May....
Study: Mimicking viruses may provide new way to defeat them
...in its tracks is to develop drugs that bind to and block
the function of virus proteins - molecules the virus produces, with the aid of host cells that help the virus replicate, or make copies of itself. The drugs, says Yin, are like hammers that knock out key functions that the virus uses for growth and r...
Purdue scientists: To stop cancer, keep your Icmt away from your Ras
...ands. So Gibbs and Hrycyna's labs joined forces to block
the biochemical activity of Icmt with small drug molecules, preventing the methyl esterification of Ras and effectively breaking its ability to localize to the plasma membrane. "This effort depended on both labs," Anderson said. "The Gibbs laborat...
Tadpoles and tumors
...ng antibodies to improve the molecule's ability to block
FAP's action. Much more research lies ahead."...
Mosquitoes vs. malaria: How we can win the fight
...04) and Science (March 26, 2004), could be used to block
the transmission of malaria from mosquitoes to hum...hancing these natural defenders, we may be able to block
the parasite-mosquito cycle," says EMBL PhD student Stephanie Blandin, who worked on the TEP1 studie...
Gladstone study reveals how genetic factor may increase risk for Alzheimer's disease
... enzyme, which they are now trying to identify and block
with drugs. "From this and our previous studies, we believe that the protease that cleaves apoE4 may serve as a therapeutic target for the prevention and treatment of Alzheimer's disease, especially in patients who are impacted by apoE4," said the se...
Failure of DNA repair mechanism precedes final stage of deadly leukemia, new Penn study shows
... a state of arrested differentiation. In order to block
ATR and DNA repair, cancer researchers also found that the concentration of BCR/ABL moves into the nucleus of the cell where DNA is produced from its original concentration in the cell's cytoplasm. Further research is planned to determine if this ...
Fetal lungs provide a signal initiating labor, UT Southwestern researchers find
...e may be able to design therapies or inhibitors to block
preterm labor," she said....
JCI table of contents, 15 March 2004
... an even greater acceleration of BCC induction. To block
ODC activity in Ptc1+/ mice, the group generated m...chemokine receptors, CCR2. The use of agents that block
CCR2 action in RA mouse models partially reduces relevant RA symptoms, indicating this receptor may ...
Memories are harder to forget than currently thought
...21 days after they were treated with anisomycin to block
the reconsolidation of a memory, we showed that they could, in fact, remember the original learned behavior," Lattal said. "If you use the anisomycin, you can destroy a 'fresh' memory, but the 'forgetting' effect of anisomycin on an established memo...
New approach limits damage after heart attack and improves survival, say Scripps Research scientists
...es long-term tissue injury. We discovered a way to block
this process and thus save heart tissue from irrev...found that a single dose of a compound designed to block
this fluid leakage (which is called edema) can, even if given as late as six hours after the event, ...
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