Gene required for formation of blood cells
...al or compound HOX gene knockout recapitulates the block in definitive hematopoiesis observed in MLL mutants, suggesting that the MLL-dependent hematopoietic program will prove to be a broader set of target genes, or a specific subset of HOX genes," writes Dr. Korsmeyer....Tissue cells can revert to stem cells
...ond, the cells in the larval ovary are unlikely to block reversion, in contrast to the cells that cluster cells encounter normally." Providing the proper conditions for reversion is likely to be a major issue in future attempts to revert differentiating cells back into stem cells. "Differentiate...Rwanda's primate-rich forests now a national park
...National Park in Burundi together form the largest block of rain forest in eastern Africa. Nyungwe was first created as a forest reserve in 1933, in response to the rapid clearing of forests for farmland in the 1920s. However, surrounding communities continued activities such as wood cutting, hunting, sma...Scripps scientists describe dangerous cocktail of alcohol, brain peptides, and neurotransmitters
... The research suggests that compounds that block CRF receptors might be a potential new therapeutic...who struggle to stop drinking. Drugs that block CRF receptors are already being looked at by scientists as potential treatments for other psychiatri...Naropin now approved for intrathecal (spinal) administration in the European Union (EU)
...on anaesthesia, for surgery using peripheral nerve block techniques and for continuous peripheral nerve block for post operative pain relief. The Netherlands acted as the Reference Member State in the Mutual Re...Rb protein's role in retina development is key to understanding devastating eye cancer
...p. What we're learning could eventually help us to block the molecular signals that trigger retinoblastoma in children." Understanding the development of tissues and organs can also help researchers understand why certain types of pediatric tumors occur. The study provides strong evidence that retinoblast...Hunter receives two major cancer awards
... the development of several anti-cancer drugs that block the activity of specific tyrosine kinases. Many of these drugs are now undergoing clinical trials, and one -- a drug called Gleevec -- has been approved to treat a specific type of leukemia. "I'm honored to have received these prestigious awards," sa...Viral immunosuppression: Not just a game of hide and go seek
...ontributes to the immune response, actually helped block DC development. This new mechanism provides us with a new perspective regarding therapeutic strategies associated with immunosuppression. In an accompanying commentary, Marco Colonna from Washington University discusses the paradoxical role of type ...JCI table of contents, March 1 2004
...ontributes to the immune response, actually helped block DC development. This new mechanism provides us with a new perspective regarding therapeutic strategies associated with immunosuppression. In an accompanying commentary, Marco Colonna from Washington University discusses the paradoxical role of type ...Tony Hunter and Raymond N. DuBois awarded Landon-AACR Prizes for Cancer Research
... ultimately yielded several anti-cancer drugs that block the activity of tyrosine kinases. Many of these drugs are now undergoing clinical trials, and one Gleevec has been approved for treatment of chronic myelogenous leukemia. "I'm honored to have received this prestigious award from the Landon Foundat...Drugs limit deadly side effects of graft-versus-host disease
...ointestinal tract," Reddy explains. "The key is to block the inflammatory cytokines, which exacerbate GVHD,...been searching for ways to neutralize cytokines or block their production. Their current work with HDAC inhibitors is an extension of this earlier research. ...Dana-Farber scientists discover natural blocker of HIV-1 virus
... of natural factors that specifically and potently block retroviruses such as HIV-1," says Joseph Sodroski,...r vision of what we might be able to manipulate to block the very early stages of HIV-1 infection," Sodroski says. Human cells contain a similar TRIM5-alpha......icient worm, showing that the inhibitor did indeed block this microRNA's function. Furthermore, the authors also used the oligonucleotides to provide evidence that two proteins, previously suggested to be involved with let-7, were directly associated with its interfering activity. Using the technique...Oxidation processes basis of interdisciplinary research, graduate training
...rs from fats. Virginia Tech food scientists try to block or slow oxidation to prevent foods from spoiling. ...et Webster is evaluating polymer systems that will block those light waves. Duncan and the students have been visiting with a Virginia polymers company about...Key advance reported in regenerating nerve fibers
...ped these inhibitory proteins up before they could block growth. "When we combined these two therapies activating the growth program in nerve cells and overcoming the inhibitory signaling we got very dramatic regeneration," said Benowitz, who is also an associate professor of neurosurgery at Harvard M...Approved drug blocks deadly anthrax toxin
...d in 2002 for treatment of chronic hepatitis B can block the action of an anthrax toxin. In the online edit...uire only small amounts of adefovir to effectively block edema factor. Such small amounts should produce few, if any, side effects in short-term use for ant...Jefferson researchers uncover biochemical clues to how cells migrate in embryos
...velopment. The researchers found that they could block the effects of Lipitor if they injected the zebrafish beforehand with mevalonate, which is what HMGCoAReductase makes. They continued along the pathway, step by step, chemically knocking out enzymes and replacing them with their products to see if t...Breakthroughs in acoustic tracking shine new light on the lives of fish
... value of a marine reserve it would do no good to block off a section of the ocean and then have all the fish swim out of the area." "Until recently, scientists have pieced together the movements of marine fish from isolated data points playing a 'connect the dots' game as fishermen reported recovered ta...Report details growing climate change threat to coral reefs
...rs concentrations of the carbonate ion, a building block of calcium carbonate that corals and other organisms use to grow their skeletons and build up the reefs. Carbon dioxide levels in the atmosphere, which were about 280 parts per million by volume (ppmv) in 1880, increased to 367 ppmv by 2000 and are e...Small amounts of alcohol or anesthetics may damage the developing brain
...when the developing brain is exposed to drugs that block NMDA glutamate activity, nerve cells in the brain ...pted them to study alcohol, which is known both to block NMDA glutamate activity and also to enhance GABA activity. They found that alcohol powerfully trigge...