Metastasis of colon cancer cells reversed in vitro
...cientists hope to be able to induce in patients to block metastasis. "The fact that the invasive process in colon cancer can be reversed is surprising," says Ben-Ze'ev. "It offers hope of reversing the metastatic process or even preventing it in the future by designing a drug that targets Slug."......the new technique, the team designed a molecule to block MMPs at one crucial step in their dance. ...A new direction for psoriasis research?
...asis." Psoriasis patients can hope that drugs that block the activity of VEGF "anti-VEGF" therapies may one day be used to treat psoriasis, much the same way that anti-VEGF therapies are currently being tested in clinical trials as a cancer treatment. "This important paper by Young and colleagues provide...Quark Biotech generates a cholesterol-free mouse
...erol, a sterol that is an indispensable structural block of cells and their membranes and plays major roles in signal transduction. The paper entitled "Generation of Viable Cholesterol-Free Mice," appears in Science , December 19, 2003 (Vol. 302, Page 2087). "We were surprised by the fact that a mouse lac...Linking the immune system with lipid metabolism
...ipids--the fat molecules that are a major building block of the human body. "This is the first time someone has shown how the immune system and lipid metabolism merge," says Associate Professor Luc Teyton, M.D., Ph.D., of Scripps Research. Teyton is the lead author of the study. In the study, Teyton ...Dec. 17 JAMA study shows new 'biologic' drug reduces psoriasis symptoms, improves quality of life
..."Biologics are injected, instead of swallowed, and block immune cells that produce the dry, flaky skin," said Gordon, who serves on the National Psoriasis Foundation's medical board. Efalizumab modulates T-cells. Found in the blood supply, T-cells bolster the body's immune response. The researchers...Scripps Research receives $3 million anonymous donation
... shown that compounds known as CRF antagonists can block the excessive drinking associated with alcohol withdrawal and protracted abstinence. The center will aim to discover and test new CRF antagonists and other compounds that might be translated into new and practical treatments for alcoholism that can ......s' physiologic response to stress using drugs that block norepinephrine's impact on T-cells. "Our current study suggests that the body's production of norepinephrine during stress makes a big difference in people trying to fight off infection," Cole said. Margaret Kemeny, John Fahey and Jerome Zack co-auth...Scientists identify molecular step that causes intoxication
...inpoints perhaps the best target yet for a drug to block alcohol's effect and potentially treat alcoholism, the scientists say. The mechanisms by which alcohol acts on the brain are thought to be similar throughout the animal kingdom, since species from worms and fruit flies to mice and humans all become...Hebrew University, German and British researchers develop means to help stress sufferers
... survival but rather to develop a drug that would block the harmful reactions of those suffering from recurring stress symptoms due to lingering memories of past traumatic experiences. Until now there has been no drug to treat the core of the post-stress problem, but rather only its symptoms. Working towa...Common airborne substance makes asthmatics more sensitive to house dust mites: study
..."There is also the possibility of finding drugs to block that interaction and prevent the worsening of asthma," Boehlecke said.Along with Alexis and Boehlecke, UNC co-authors were Drs. Milan Hazucha, Robert Jacobs, Parker Reist, Philip A. Bromberg and David Peden.......or example, a better artificial sweetener or that block taste, such as an additive that could be used to block bitter tastes." In the study, Liman and Liu looked closely at a protein necessary for detecting s...Use of new direct thrombin inhibitor may be as effective as current standard treatment
...l of the vein and migrate to the lungs, where they block a pulmonary artery or one of its branches. The American Society of Hematology is the world's largest professional society concerned with the causes and treatment of blood disorders. Its mission is to further the understanding, diagnosis, tr...New advances in thrombosis help further understanding of disease prevention
... pulmonary embolus (PE). When this happens, clots block a pulmonary artery or one of its branches, disrupting the lung's blood flow and the addition of oxygen to the blood. Drugs used to treat deep vein thrombosis fall into three general classes: (1) anticoagulants, which inhibit blood coagulation a...Scientists solve puzzle of how kinesin motor molecules walk or limp across cells
...ong. It may be possible to develop therapies that block the kinsein motion and prevent bad things from happening. In the future, it may even be possible to develop less toxic therapies that target specific kinesins in cancer cells, without damaging the healthy ones." For example, taxol, a drug commonly u...Unraveling a protein, researchers uncover mechanics of anti-cancer agent
...n, but its ability to initiate matrix assembly and block the spread of cancer cells remained a mystery. Using crystallography, atomic force microscopy and advanced computer modeling, researchers sorted the chemical structure and mechanical strength of the known fibronectin proteins that glue together myria...Chromosomes are 'nibbled' before they fuse, researchers report
... that work with exonucleases may offer a target to block the process and push cells in cancer toward death instead of genomic instability....UT Southwestern researchers' discovery may lead to gene targets for new form of contraceptive
...uld be designed that would bind to the protein and block its function, then those sperm cells would be rendered ineffective or infertile." Such an ion channel-blocking contraceptive would likely be fast acting, Dr. Quill said. It also could have fewer side effects than other available contraceptives, as it...Scientists uncover novel role for estrogen in bone marrow
...d be candidates for drugs designed to specifically block 3b-HSD or estradiol receptors to effectively normalize their platelet levels....Effects of maternal myasthenia gravis on pregnancy and birth examined
... of the immune system make protein antibodies that block nerve impulses to their muscles. The major symptom of MG is muscle weakness that is worsened by fatigue and generally improves with rest. The prevalence of MG is estimated at about 1 in 10,000. About 15 percent of infants born to women with MG are th...