Researchers Find Possible New Route to Making Cancer Cells Vulnerable
...he MDR pump for many years. But many promising MDR blockers haveturned out to be toxic in the doses needed for them to be effective. "The MDR protein is so big that its FKBP12 component is like a fleaon an elephant's back," said Heitman. "But it appears to be crucial.Based on our experiments, we thin...Researchers Corral Millions Of Microscopic Membranes
... might be used to screen for drugs such as channel blockers that interact with receptors on a cell's surface and interior membranes, the researchers said.The starting point for the project was research that was completed in 1986 and 1987 by Stanford chemistry Professor Harden McConnell. He and his students fi...Scientists Find New Trigger For Nerve Cell Death
...t be possible to use drugs called potassiumchannel blockers to stem potassium loss and prevent nerve cells from dying. Thismight restrict damage to the initially injured area of the brain or spinal cord,allowing patients to recover more fully. Yu got his idea by considering how apoptotic cells d...Duke Researchers Genetically Engineer Mice To Block Heart Enlargement
...nsconsisting of multiple medications, such as beta blockers and ACE-inhibitors, toblock the various hormones that produce a strain on the heart. If these drugsfail and the disease progresses, patients can receive a heart transplant as alast resort. "Right now patients with hypertension are treated wit......gh calcium concentrations andmitochondrial calcium blockers lived. Calcium ultimately may ruin mitochondria through a number of mechanisms,according to Dr. Reynolds. Normally, mitochondria can absorb excess calciumfrom cells. But constantly cycling calcium out of the cytoplasm may sapmitochondria of......pirin, the drugs called platelet IIb/IIIa receptor blockers keep blood platelets from clumping and forming blo...r a heart attack or stroke. However, the platelet blockers -- sometimes called "super aspirins" and sold under the generic names of eptifibatide, tirofiban an...MGH research shows gene therapy may be able to reverse heart failure
...marily medications such as ACE inhibitors and beta blockers - can slow theprogression of heart failure but not stop the condition. The only current cure, for which mostpatients are ineligible, is a heart transplant. Almost half of those diagnosed with heart failurewill not survive five years after their dia...UF researcher develops high blood pressure drug using gene therapy technique
...ients are taking beta-blockers and calcium channel blockers and angiotensin receptor blockers, so clearly the body has a way to get around this."...Study stopped early: high blood pressure drug less effective than diuretic
...ion people nationwide take Cardura and other alpha blockers (Hytrin or Minipres) to lower blood pressure. "...ions from ALLHAT to physicians is not to use alpha blockers as a first-line therapy," said Furberg. "Our advice to the public is to consult with your physician ...Potent new compound from blue-green algae may help treat, elucidate nerve disorders
.... Such painkillers as lidocaine are sodium-channel blockers as well. "These disorders, including neurodegenerative diseases, could be treated by selectively activating and blocking sodium channels," said Gerwick. "So even if kalkitoxin doesn't become a useful pharmaceutical itself, it's a valuable tool to und...Enzyme is key to hallmark of Alzheimer's-- moves to block it underway
...atients a "cocktail" of various enzyme-blockers or blockers along with vaccines. "Both approaches may prove useful in treating Alzheimer's," Wong explains. Beta-secretase works by trimming pieces off a larger molecule that's parent to the plaque protein, beta amyloid. Forming amyloid is a natural cell proc...In possible boon to sickle cell victims, basic scientists find reason cells stick
...odel of sickle cell disease and evaluate potential blockers there," Brittain said. "We are still years away from taking this into the clinic, but we are one step closer than we were a year ago." About 150 in every 100,000 U.S. black children suffer from sickle cell disease, also known as sickle cell anemia, ...New clues to how RNA exits the nucleus
...ues will also use cell-permeable peptides to carry blockers of other candidate adapter proteins, in an attempt to reveal their role in yet other export pathways. HHMI assistant investigator Melissa Moore at Brandeis University emphasized that cell-penetrating peptides should have broad applicability. The mo...Columbia team finds treatment that corrects cellular defect at the root of heart failure
...University have shown for the first time that beta blockers - drugs used to treat cardiovascular disease - can... Marks' study used animal models to show that beta blockers prevent excess phosphorylation of the ryanodine receptor, allowing it to respond to cellular signali...Excessive growth of bacteria may also be major cause of stomach ulcers
...sized, however, that current over-the-counter acid blockers like Pepcid AC, Zantac, and Tagamet, a class of drugs called H2 receptor antagonists, will not trigger significant bacterial overgrowth because they do not suppress acid as completely as proton pump inhibitors. In general, the medical community needs...Tracing the neural circuitry of second sight
...es at Brown University report used pharmacological blockers to show that the retinal ganglion cells projecting to the SCN are, indeed, photosensitive by themselves. Berson, who also collaborated on Yaus Science article, did key experiments to show that intrinsic photosensitivity and the expression of melano...Australian frog is first to make its own chemical weapons
...on. The pseudophrynamines were found to be potent blockers of nicotinic receptors, which are involved in neurological function. The researchers are planning to investigate the alkaloids for other biological activities. Most frog skin alkaloids are biologically active and many have been developed as biomedica...Common asthma drug saves patients money, trips to hospital
...gs called leukotriene receptor blockers - drugs that help decrease the inflammation induced by asthma. Although the National Heart, Lung and Blood Institute recommends that patients with mild, persistent asthm...New possibilities for deadly childhood brain cancer
... Hedgehog signaling." Beachy says other Hedgehog blockers will likely be found to kill medulloblastomas, too...e developing embryo.) The search for new Hedgehog blockers may be accelerated by research reported in the Aug. 22 issue of Nature. A team led by Beachy describ...University of Maryland research reveals true target of calcium channel blockers
...ments. The researchers found that calcium channel blockers primarily affect a group of cellular calcium chann...s. Prior to this discovery, scientists thought the blockers selectively affected what are known as "voltage-gated" channels. "Our research has significant impl...