Phase II trials of second-generation antisense cancer drug planned following successful early study
... I study, which has demonstrated that the new drug blocks its target gene in exactly the way it is designed to do. In the Phase I study the drug OGX-011* inhibited the production of clusterin, a protein that protects cell survival and is widely distributed in body tissue. Clusterin is implicated in a rang...Researchers identify protein promoting vascular tumor growth
...mors," Gordillo said. "Antibody-based therapy that blocks MCP-1 may be effective in substantially limiting the incidence and quality of the malformation." A new treatment option is needed because current therapies including steroids and alpha interferon have a number of high-risk side effects. Stero...Evidence builds for potential new cancer drug target
...ncer is reduced. "We hope to develop a drug that blocks the harmful activity of this gene in the near future. This finding was very serendipitous. We used to think c-myb was only associated with the development of leukemia but found that it's also involved in the development of breast cancer," said Reddy....Wisconsin scientists develop quick botox test
...ings. The toxin is taken up by the nerves where it blocks chemical signals from reaching muscles. With enough blocked nerve endings, the toxin can cause paralysis and death. In recent years, the nerve toxin has been used therapeutically to treat nerve disorders and help calm the muscles of cerebral palsy an...Experimental drug shown to block mutant protein causing blood disease
... blood disorder by using an experimental drug that blocks signals promoting runaway growth of blood cells. T...ting down abnormal kinase signal switches. Gleevec blocks uncontrolled growth signals in Chronic Myelogenous Leukemia and Gastrointestinal Stromal Tumor. The ...'Fossil genes' reveal how life sheds form and function
...of holes," where numerous DNA bases - the building blocks of all genes - have been edited out through mutation to terminate the physiological message they were responsible for transmitting along the pathway. "Genes become fossilized if there is no use for them," says Rokas. "If you relax the pressure on the...Research suggests new avenue for stopping, preventing colon cancer
...r growth," the researchers concluded. A drug that blocks PPARdelta has been developed in France, and the Va...e COX-2 enzyme produces another prostaglandin that blocks clot formation and dilates blood vessels. Long-term, high-dose use of the COX-2 inhibitor Vioxx has ...Algal contact as a trigger for coral disease
...nes in reef-building coral species, the foundation blocks of coral reef ecosystems. The emergence of these diseases has occurred simultaneously with large increases in the abundance of seaweeds, called macroalgae. Macroalgae frequently interact with corals, usually by overgrowing them from their edges. In t...A probable cause for high blood pressure identified - shows links with diabetes
...ressure. When an antagonist (another molecule that blocks the action of the first) is given, imidazole-4-acetic acid-ribotide's high blood pressure effect is inhibited. While some causes of high blood pressure are clearly established, the majority of cases are considered "essential hypertension," that is h...Images of 'tail' of protein needed for cell multiplication suggest anticancer drug targets
...s the ability of E2 to transfer NEDD8 to Cul1, and blocks its ability to drive cell proliferation. This demo...iews of half of the individual amino acid building blocks making up the protein tail. This problem was overcome using a technique specially developed by Rober...Natural mineral locks up carbon dioxide
...This solid can be used to manufacture construction blocks and there is also a small market for hydrated magnesium carbonate in the cosmetics industry. The silicon dioxide can be used to remove sulfur dioxide from the flue gases, which can subsequently be converted to sulfuric acid to use in the first part o...Battle between bubbles might have started evolution
... vesicles loaded with the basic molecular building blocks of genetic material, called nucleotides. Next, they used RNA segments, and finally a large, natural RNA molecule. In all cases, they saw that the vesicles swollen with genetic material grew, while those with no genetic material shrank. It is importa...New genetic research demonstrates possible cause of inherited form of Parkinson's disease
...ail to deliver its own garbage to the dump, but it blocks all the other garbage trucks and the town fills up with garbage," said Dr. Sulzer. Together with Ana Maria Cuervo, M.D., Ph.D., assistant professor of anatomy and structural biology at Albert Einstein College of Medicine and the study's lead author,...Scientists reinvent DNA as template to produce organic molecules
...ry modest set of protein and nucleic acid building blocks has given rise to the incredible complexity and diversity of living systems," says David R. Liu, associate professor of chemistry and chemical biology at Harvard. "We're interested in marrying fundamental features of biomolecules with synthetic organ...ASU researchers demonstrate new technique that improves the power of atomic force micrscopy
... atomic force microscopy (AFM) is feeling the Lego blocks on the floor, but it can't tell the difference bet... the person sitting on the floor and feeling those blocks to open their eyes and see that there are red Lego blocks, green Lego blocks and yellow Lego blocks....RNA could form building blocks for nanomachines
...truction of three-dimensional arrays made from RNA blocks of different shapes and sizes," said Peixuan Guo, ...atching RNA molecules, we can program RNA building blocks to bind to each other in precisely defined ways," he said. "We can get them to form the nano-shapes ......romone and metyrapone, achemical that specifically blocks the enzyme, they could smell thepheromone at first but then could not reset their antennae. They wereunable to smell new doses pheromone for several minutes. The treatment had no effect on other insects, because the enzyme isvery specific to that ph......discovered that mefloquine, an anti-malarial drug, blocks two gap junction proteins, or connexins, in low do...ut mefloquine in adult mice precisely and potently blocks connexins called Cx36 and Cx50. There are about 20 kinds of connexins in the brain and eye, as well ...Revealing bizarre deep-sea secrets
...ured on the sub's video camera using a filter that blocks non-fluorescent light reflected back. The filter can also be removed using the sub's robotic arm to allow filming of non-fluorescent views for comparison. To gain yet another new view of the deep, Dr. Justin Marshall from the University of Queensland...... hamsters with either oxytocin or a substance that blocks oxytocin production. Hamsters in the oxytocin treatment group were given oxytocin injections daily for five days prior to wounding and restraint stress, while control animals were given a saline placebo. The treated animals' wounds healed at a faster...