Sweet success in targeting sugar molecules to cells in living animals
...rtozzi. "And there are changes in glycosylation of blood vessels at sites of chronic inflammation that are characteristic of disease. There are even some reports in changes of glycosylation in the brains of people who have prion disease or Alzheimer's disease," she said. Additional studies suggest that gly...The first engineering of cell surfaces in living animals
...abundance of cell-surface azides. Because rodent blood has high levels of esterase, enzymes that might interfere with the conversion of the modified precursor, the first experiments were done with esterase-deficient knockout mice. Later the investigators found that wild-type mice displayed just as many c...New model can aid in understanding immune system diseases
...cess, a protein called CD40 signals B cells (white blood cells) to divide and make antibodies against infection, then terminates the signal when the need for the immune response is gone. LMP1 also triggers B cell activation, but in contrast to CD40, fails to stop it at the appropriate time. "The viral pro...Putting energy into heart protection
... pressure in the left ventrical. Upon reduction of blood flow to the heart, to simulate a heart attack, the... they breakdown fatty acids to replenish ATP. Once blood flow returned, contractile function in the left ventrical of the mutant mice was impaired. The auth...JCI table of contents, 16 August, 2004
... pressure in the left ventricle. Upon reduction of blood flow to the heart, to simulate a heart attack, the... they breakdown fatty acids to replenish ATP. Once blood flow returned, contractile function in the left ventricle of the mutant mice was impaired. The auth...MICs shed light on prostate cancer
...and that there were high levels soluble MIC in the blood serum of these patients. These data showed that the later stage tumors were shedding the MIC from their cell surfaces, and that this was the means by which prostate cancer cells could overcome this particular form of immune surveillance. Th...Rare mutations can significantly increase risk factor for heart disease
...tations in a few genes can be sufficient to affect blood cholesterol levels. According to the researchers, ...t disease because it transports cholesterol in the blood back to the liver, leading to its removal from the body and preventing its buildup on artery walls. ...Stem cell research targets cerebral palsy
.... Chemokines are growth factors that attract white blood cells and are quickly summoned to the site of an injury, such as a brain injury that occurs in cerebral palsy. More recently, researchers have found that chemokines also seem to attract stem cells to an injury site. However, at least in an animal mod...Hopkins scientists use blood proteins to detect ovarian cancer
...s Kimmel Cancer Center researchers have designed a blood test to detect ovarian cancer using three proteins found in common in the blood of women with the disease. Their preliminary studies with the new test suggest a molecular signatur...Genes can influence both alcohol consumption and dependence
...alcohol-related problems like road trauma and high blood pressure occur in those who are drinking above rec...996) and completed in 1995 with the acquisition of blood samples (n=3,378), examined items of alcohol consumption as well as possible diagnoses of alcohol de...Marijuana ingredient inhibits VEGF pathway required for brain tumor blood vessels
...ngredients in marijuana, restrict the sprouting of blood vessels to brain tumors by inhibiting the expressi... studies, have been shown to inhibit the growth of blood vessels, or angiogenesis, in laboratory mice. However, little was known about the specific mechanism...Infant rats eagerly accept high concentrations of alcohol upon first exposure
...bsolute alcohol ingested per unit body weight, and blood alcohol concentration. The infant rats ingested ex...ch professor at Binghamton University, "comparable blood alcohol concentrations will be reached after about 12 to 15 drinks such as bottles of beer, glasses...Applied Mathematical Models in Human Physiology
...ogy. In particular, they present models describing blood flow in the heart and the cardiovascular system, a...llent introduction for researchers in the study of blood flow in the heart and can be used as a source of case studies for graduate students in the areas of ...Leukemia stem cells identified by Stanford researchers
...cells and found they resembled normal cells in the blood called granulocyte/macrophage progenitor cells. Th...tem cells in the bone marrow that produce both red blood cells and immune cells. Instead, Jamieson found that the cancer started when a normal adult cell mut...Rutgers-Newark scientist: Mosquitoes may carry lethal parasite
...tube. Mosquitoes secrete an anti-coagulant to keep blood from clotting as they drink, temporarily leaving a clear passage directly into the bloodstream. New research by Cali and one of her graduate students will be aimed at identifying how prevalent B. algerae is in mosquitoes in New Jersey through the col...Joslin Diabetes Center launches research section on developmental and stem cell biology
...ese complications involve damage to large or small blood vessels. Stem cells show promise repairing blood vessels, so researchers hope that they might be able to undo some of the long-term damage that resul...Jefferson scientists find gene expression pattern may predict behavior of leukemia
...nes in human CLL samples with that of normal white blood cells, or lymphocytes, called CD5+ B cells. CLL, the most common adult leukemia in the Western world, is characterized by an abnormal increase in the number of B cells. "We found two specific genetic signatures," Dr. Croce says. One expression patte...Study links high carbohydrate diet to increased breast cancer risk
...ets and starches causes a rapid rise in the body's blood sugar levels, which in turn cues the production of insulin and triggers a biological process that ultimately can influence carcinogenesis by causing cells to proliferate. Insulin and an insulin-like growth factor also may contribute to higher cir...LBP-1a gene mutation linked to disruption of normal fetal development
...P-1a in the mouse embryo prevents normal growth of blood vessels in the placenta. This finding suggests tha...this family is essential for normal development of blood vessels outside the growing embryo. A transcription factor is a protein that activates a gene and in...