Early dexamethasone exposure has long-term neurodevelopment, neuroendocrine effects
...xiety and, in response to a mild novelty stress, a blunted corticosterone response. However, the findings from this research could not establish if these alterations were permanent. A New Study A new study sought to test whether effects of neonatal dexamethasone exposure on LHPA axis function persist to ...JCI Table of Contents, January 15 2004
... Under stressful conditions, ACTH levels were also blunted in V1bR-/- mice. The data demonstrate that the V1b receptor plays a crucial role in regulating HPA axis activity under both stressful and resting conditions. Clinical implications include the possibility that drugs that regulate V1b receptor activity...Alcoholics with antisocial personality disorder have blunted emotional reactivity
...nal responsiveness. Researchers speculate that the blunted responses found in this subgroup of alcoholics may be related to poor inhibitory abilities, which may, in turn, facilitate the development of alcoholism. Emotional reactivity refers to how people respond to both pleasant and unpleasant events, inclu...JCI table of contents, 15 October, 2003
...nstrates that mice deficient in uroguanylin have a blunted ability to excrete sodium in their urine in response to excess oral sodium intake, and they also exhibit elevate blood pressure. The study indicates that there is a role for uroguanylin and a link between the intestine and kidney in maintaining a bal...Adult alcoholism and attention-deficit hyperactivity disorder are connected
...the circulating prolactin. This usual increase is blunted in subjects with ADHD or alcoholism. The main structures responsible for the fenfluramine-induced prolactin release are the 5-HTT and the 5-HT2c receptors. Therefore, both seemed plausible as overlapping sources of genetic liability of ADHD and alc...Can heart failure impair thinking?
...ies are characteristic of HF and are manifested as blunted baroreceptor activity, diminished parasympathetic effects on the sinoatrial node, increased norepinephrine, decreased heart rate variability, and diminished responsiveness and number of 1-receptors. These characteristics may result from peripheral o...New study clarifies connection of brain and heart failure
...er excretion, and augmented sympathetic drive with blunted baroreflex, were dramatically attenuated in animals with an AV3V lesion. Second, the expected increase in plasma renin activity did not occur in the AV3V-lesioned MI rats. These findings clearly implicate the forebrain as an active participant in the...Marijuana receptor gene abnormality in schizophrenia
...acterized by predominant negative symptoms such as blunted affect, disorganized thought and deterioration of personality. Such symptomatic features of hebephrenic schizophrenia bear resemblance to chronic cannabinoid psychoses. Although acute use of cannabis can induce diverse types of psychotic state, suc...New depression studies reveal persistent serotonin system abnormality in patients
...nfirmed. They found that depressed people showed a blunted hormonal response to a test he developed that boos...te of remission, most of them still demonstrated a blunted hormonal response to serotonin challenge," Golden said. "That means that even when they are well, th...Physical effort does not automatically lead to worsening of fibromyalgia symptoms
...ibromyalgia undertaken during exercise indicated a blunted response. It is known that healthy subjects, exercise induces activation of muscle sympathetic nervous activity, as well as more general SNS activity, especially when the exercise exceeds a certain level or duration. The SNS activity during exercis...A green tea extract could help alleviate shortage of livers available for transplant
...percent to 13 percent. Green tea extract largely blunted graft injury and increased survival of fatty livers to 75 percent. Ethanol administered to donor rats increased POBN/radical adducts 2.5-fold and caused accumulation of 4-hydroxynenonal, a product of lipid peroxidation, after transplantation. These ...An animal study raises additional concerns about the use of dexamethasone on premature infants
...light and dark environments, while demonstrating a blunted serum corticosterone (the principal glucocortoid in the rat) response to a novel stress. Conclusions Given that adequate glucocorticoid activation is vital for learning memory acquisition and is dependent on optimal exposure to elevated glucocorticoi...APS August/September journal hot picks
...cute heavy-resistance exercise is accompanied by a blunted LH production rate and elevated C concentrations. Source: Journal of Applied Physiology, August 2001 TEACHING SCIENCE Can Students Learn - and Like - Biology? Yes, If. Summary: As evidenced by national and regional efforts, colleges are striving...Gene therapy technique reduces alcohol consumption in rats
... Volkow hypothesize that DRD2 depletion produces a blunted pleasure response that leads alcoholics to increase their intake. The research team performed two experiments for the current study-one to evaluate the rats' DRD2 receptor levels and one to evaluate drinking behavior at different time points followin...Gene therapy reduces drinking in "alcoholic" rats
...olics increase their intake to try to override the blunted pleasure response, and that people with low levels of D2 receptors may be predisposed to alcohol abuse. These ideas led the Brookhaven researchers to hypothesize that increasing the level of D2 receptors might decrease alcohol intake. The researchers...Abnormalities in stress hormone response among alcoholics
...ith shorter lengths of abstinence found they had a blunted or unchanged stress response following serotonergic stimulation. We also found that the stress hormone response in recovering alcoholics did not return to baseline levels as quickly as it did in age- and race-matched non-alcoholic comparison subject...Study links impulsive violence with brain's inability to regulate emotion
... activity in the orbital and anterior regions were blunted or entirely absent in many of the study groups, while the amygdala showed normal or heightened activity. The inability of the two brain regions to effectively counteract the response of the amygdala may help explain how threatening situations can bec......ignals telling the cell that it is time to die, is blunted by high cGMP-PDE activity in neoplastic cells. If cGMP does not rise, PKG is not activated and the pathway culminating in apoptosis is blocked." Company scientists also reported new research studying cancer cell responses to cGMP-PDE inhibition ...Scientists ID A Protein With Punch As Infection-Inflammation Fighter
...their ability toproduce the free radical oxygen is blunted to 30 percent of normal level. Such'down-regulation' was a critical finding, said Blecha. "That's when we began to wonder: Could PR-39 be useful as an inflammationfighter?" he added. Since 1995, the KSU team has acquired collaborators who are extendi...