St. Jude researchers use DNA chips to determine how leukemia cells respond to different drugs
...and non-functional white blood cells overwhelm the bodys ability to make normal blood cells in the bone marrow. It is the most common type of cancer in children, with about 3,000 new cases each year. Custom designing therapy, based on patient's leukemic-cell and normal-cell genetics, as well as the geneti...Programmable antibodies-- hybrid cancer therapy described by scientists at Scripps
...ch is a protein produced in great abundance by the bodys immune system and found naturally in the bloodstream. The hybrid of the two, described in an upcoming issue of the journal Proceedings of the National Academy of Sciences, was found to have a profound effect on the size of tumors in mouse models--shr...In a noisy world, how can the senses project and receive information at the same time?
...hy doesnt the active voice smother the rest of our bodys sensory systems? The answer to these questions may be found in the simple male cricket (Gryllus bimaculatus), which sing for hours at over 100 decibels sound pressure levels (dB SPL) in order to attract females. Background The songs of crickets (e...New immune-boosting cancer treatment shows promise
...roach enhances attacks on tumors while sparing the bodys own tissue. The results of the phase I clinical tr...stem T cells, and prevents them from attacking the bodys own tissues. In studies in mice, Allison and his colleagues identified an antibody that blocks CTLA-...Perlegen scientists find genetic basis for difference between humans and non-human primates
...in concert to cause common diseases and affect the bodys response to drugs. Perlegen has ongoing research collaborations with partners including Bristol-Myers Squibb, Eli Lilly & Co., GlaxoSmithKline, Pfizer and Unilever....CIIT research on estrogens featured at national meeting
...en-like substances in a normal diet may affect the bodys response to synthetic chemicals. Genistein is found in soybeans and soy-based foods. The news conference will begin at 10 A.M. on June 19th at the Moscone Center. Dr. You will also present his research as part of a poster session entitled "Gene Regu...Welch Award honors McConnell for insights into physical chemistry, cell membranes
...egulation of cholesterol and the activation of the bodys immune system. Today, The Welch Foundation announced that Dr. McConnell will receive its 2002 Welch Award, a $300,000 prize given for lifetime achievements in basic chemical research, in recognition of his contributions. Dr. McConnell, the Robert Eck...New depression studies reveal persistent serotonin system abnormality in patients
...s C. Garbutt, professor of psychiatry. One of the bodys most important neurotransmitters, serotonin helps regulate many emotional and physiologic functions that are disturbed when people suffer from depression, Golden said. With the help of 20 affected patients -- plus non-depressed "control" subjects --...Studying the strength of protein bonds one molecule at a time
...gs, at the single molecule level." Clotting is the bodys first defense against damage to blood vessels. When damaged, the cells that make up blood vessels release chemicals that activate passing platelets, causing them to adhere to the surface and aggregate. When activated, platelets change shape and expos...Cell Genesys reports long term survival data in Phase II trial of GVAX prostate cancer vaccine
... hormone which plays a key role in stimulating the bodys immune response to vaccines. GVAX cancer vaccines have demonstrated antitumor effects against every type of human cancer against which they have been tested to date and are currently being evaluated in five types of cancerlung, prostate, pancreatic,...NYU biologists develop better way to 'silence' neurons
...ctrical activity in neurons plays in governing the bodys circadian rhythms, or internal clock. It may also help in the future development of more effective treatments for diseases that are caused by aberrant electrical activity in neurons and other electrically excitable cells and tissues. The findings w...Researchers uncover biochemical connection between high-fat diets and increased colon-cancer risk
...shed in todays edition of Science, reveal that the bodys natural mechanisms arent built to handle lithochol... show that at least part of the answer lies in the bodys inability to cope with large amounts of lithocholic acid, produced when the body processes cholester...Scientists discover protein identifies damage to DNA
...lready was known, senses damage to DNA so that the bodys natural repair system can kick into action, the researchers found. A report on the UNC School of Medicine findings appears in the May 14 issue of the Proceedings of the National Academy of Sciences. Authors are postdoctoral associates Keziban Unsal-K...Biologists take new look at metabolism
...to be supported when it was found in 1883 that the bodys surface-to-volume ratio or the 2/3 power of body mass. Another slightly different number was developed in 1932, which since that time, many investigators have contested or rationalized, according to Wiebel. "There may not even be a single power l...Natural compound used in India reduces cholesterol by blocking metabolism-controlling receptor
...olleagues previously had revealed FXRs role in the bodys conversion of cholesterol to bile acids. When the bile acids reach a certain level in the body, FXR is activated to interrupt the cholesterol-to-bile-acid process. The receptor keeps bile acids in check, Mangelsdorf said. If you disturb it, it change...Leprosy bug provides clues to early nerve degeneration
...rvous system (PNS). The findings suggest that the bodys immune response does not play a significant role i...called antibodies, while T cells help regulate the bodys immune response). As in the cell culture model, direct administration of both M. leprae and its cell...HIV selectively suppresses anti-HIV defense cells
... response to various pathogens. HIV undermines the bodys ability to protect against disease by depleting th...hat the mature ones rush to the front lines of the bodys battle against HIV and are therefore exposed to more of the virus than are cells that fight other pa...Drug breaks for HIV-infected individuals may put certain immune cells at risk
...o regenerate these HIV-specific CD4 cells once the bodys supply has become infected, or even if regeneration occurs with re-initiation of anti-viral treatment. During the treatment interruption, although HIV-fighting CD8 cells increase, HIV-specific CD4 cells also become infected if the virus is allowed to...UNC, other physicians setting up national registry
...w immunological approach designed to shut down the bodys production of the abnormal antibodies. ...Study yields new clues on bodys rejection of transplanted organs
...ime that certain white blood cells may trigger the bodys rejection of transplanted organs even without help...ype of white blood cell), which play a role in the bodys immune system. Scientists have long believed that T cells rely on the spleen and lymph nodes to mou...