Tag: "botulinum" at biology news
Disease Takes Its Toll On Waterfowl Populations
...yzing toxin produced by the bacterium, Clostridium botulinum
type C. The toxin is closely related to botulism toxins A and B, which are responsible for a similar food-borne disease in humans. Affected birds lose coordination and show signs of paralysis of the legs and wings and labored breathing. In advance...
Jefferson Scientists Develop Botulism Vaccine
...y to create a modified and non-toxic version of botulinum
toxin, which is natures deadliest poison. The toxin, which is the cause of the disease botulism, is ordinarily encountered as a form of food poisoning. When someone ingests the toxin, it survives the harsh conditions of the gastroin...
Scientists decipher structure of toxin responsible for botulism
... UPTON, NY -- The toxins produced by Clostridium botulinum
bacteria are among the deadliest known to humankin...is," Swaminathan says. The current studies were on botulinum
neurotoxin B, one of seven types produced by Clostridium botulinum
bacteria. Scientists have previou...
Worms point the way on nerve disease
... Some milder types of dystonia can be treated with botulinum
toxin injections, but there is no cure. Lesilee Rose, an assistant professor of molecular and cell biology at UC Davis, discovered the gene, called OOC-5, while looking for genes that control cell division in Caenorhabditis embryos. Rose and gradua...
First drug developed for widespread use against botulism
...tudy points out. The new drug potently neutralizes botulinum
toxin and can be readily mass-produced, the resear...s isolated and identified three antibodies against botulinum
toxin and combined them. Each antibody is capable of binding to a different part of the toxin molecu...
University of Ulster develops DNA fingerprint techniques to fight bio-terrorism
...rist agents such as Cryptosporidium or Clostridium botulinum
can take up to five day, but Dr Lowry's new DNA Finger Printing technique takes only 15 minutes, saving a vital diagnostic time in the event of a biological warfarea attack. The importance of Dr Lowery's work has ben rexognised by the award of a pres...
Biological and chemical agents in terrorism examined at AAN Annual Meeting
...n such biological toxins as anthrax, smallpox, and botulinum
toxin, their use in war and as terrorist weapons of mass destruction. "The recent insurgence of national and international terrorism is a potential threat to the world as a whole," says Mishra. "Lessons learned from the past will be a guiding force f...
IUPAC report- Natural and synthetic substances
...hetic origin. Extremely toxic substances, such as botulinum
toxin and ricin, may be obtained from natural sources. The toxicity of a compound is generally related to its dose level, and even the most toxic substance (Botox) can have medically useful properties in minute doses. The safety and efficacy of a d...
Researchers identify botox receptor
...unction alongside gangliosides as the receptor for botulinum
neurotoxin B - one of the four types deadly to hum...is the first to identify a receptor for one of the botulinum
neurotoxins and establish its entry route," says Dong, first author of the paper. "This knowledge wi...
Tufts University wins $25-million NIH contract
...n the U.S. involved with comprehensive research on botulinum
neurotoxin production - will triple its existing 3,500-square-foot laboratory to accommodate the new center's mission to develop botulism treatments and design diagnostic strategies....
US crackdown on bioterror backfiring
...nd the BSE prion that causes mad cow disease. Even botulinum
toxin is on the list, though the medical version, Botox, is exempt from the regulations. People working with select agents now have to register with the government, put their fingerprints on record, get security clearances, and have their labs inspec...
Small-molecule inhibitors of botulinum neurotoxin identified
...timately leads to suffocation and death. Because botulinum
neurotoxins are capable of causing mass casualties, they are classified as biodefense A (top priority) agents by the Centers for Disease Control and Prevention. Currently, no therapeutics exist to counter the threat; thus, identifying and developing...
Botulinum toxin structure offers clues for vaccines/treatments
... atomic-level structure of the catalytic domain of botulinum
toxin type E -- one of seven neurotoxins that caus...gate the fear." There are seven known varieties of botulinum
toxin, types A-G. They block the release of neurotransmitters, the chemical messengers nerve cells u...
Labs-on-a-chip to detect milk contamination
...he technique to rapidly detect the botulism toxin, botulinum
neurotoxin, the most poisonous substance known. "A...gues reported. "Due to its high specific toxicity, botulinum
toxin is also considered a potential agent for use in bioterrorism." The botulinum
toxin can be dete...
Symptoms of foodborne botulism may help predict fatality
...lly occurring bacterium, Clostridium botulinum. C. botulinum
produces a potent neurotoxin that can have drastic effects on the body. Symptoms include double vision, dry mouth, difficulty swallowing, dilated pupils, drooping eyelids and slurred speech, followed by eventual paralysis. Researchers from the U.S. ...
Wisconsin scientists develop quick botox test
...ison have developed a pair of rapid-fire tests for botulinum
toxin, a feat that could underpin new technologies...apman, describes the development of two assays for botulinum
toxin - one a real-time test - that vastly improve on current technologies to detect the deadly pois...