Tag: "brca" at biology news

New study confirms conservation surgery is safe for BRCA breast cancers

Hamburg, Germany: Women who carry the BRCA breast cancer genes[1] can safely be offered breast conservation surgery with radiotherapy provided they are followed up for the rest of their lives....... That is the conclusion of a team of researchers from the Institut Curie in Paris after studying a group of these high-risk patients for a median nine years after surgery for breast cancer. They found...

Mastectomy dramatically reduces breast cancer risk among women with BRCA1/2 mutations

Alexandria, VA-Two studies from the Abramson Cancer Center at the University of Pennsylvania appearing online in the Journal of Clinical Oncology (JCO) have important implications for women with BRCA1 and BRCA2 mutations. The first study shows that bilateral prophylactic mastectomy can reduce breast cancer risk by more than 90% in women with BRCA1 and BRCA2 mutations, and may be even more effect...

BRCA mutations not associated with colorectal cancer risk, studies suggest

Two studies in the January 7 issue of the ... Mutations in BRCA1 and BRCA2, which are present in about 2.5% of the Ashkenazi Jewish population, have been associated with an increased risk of breast and ovarian cancer, but it is unclear whether these mutations also increase the risk of colorectal cancer. Some studies have suggested an increased risk of colorectal cancer among mutation carriers, w...

BRCA mutations do not increase risk of colorectal cancer

ANN ARBOR, MI People with mutations in BRCA genes or a family history of breast cancer now have one less thing to worry about. Although their chances of developing breast or ovarian cancer are high, new research shows their colorectal cancer risk is about the same as that of the general population....... "People carrying BRCA1 or BRCA2 mutations already have their plates full managing a high ris...

Poor prognosis linked to BRCA1 mutations

Breast cancer patients have a lower chance of long-term survival if they carry an inherited mutation in the BRCA1 gene, according to research published in Breast Cancer Research this week. However, the poor prognosis associated with the mutated gene is mitigated by chemotherapy....... The breast cancer susceptibility genes, BRCA1 and BRCA2, were identified over eight years ago, but the best way o...

Childhood brain tumors associated with rarely inherited BRCA2 gene mutations

NEW YORK, October 15, 2003 New research led by scientists at Memorial Sloan-Kettering Cancer Center and The Rockefeller University shows that pediatric brain tumors and Fanconi anemia can develop among children in the rare instance that both parents carry mutations of the BRCA2 gene. The work will be published in the October 15 issue of the Journal of the National Cancer Institute. ... ...The re...

BRCA2 mutations may be associated with some hereditary pancreatic cancers

Mutations in the breast cancer susceptibility gene BRCA2 may be associated with a predisposition to familial (hereditary) pancreatic cancer, a new study suggests. The findings appear in the February 5 issue of the . ...... Familial pancreatic cancers account for as many as 10% of all pancreatic cancer cases. Although no specific gene has been definitively linked to familial pancreatic cancer, so...

Cancer-linked BRCA2 gene plays previously unsuspected role in cell division

.Philadelphia -- The BRCA2 gene, linked to familial breast and ovarian cancers, plays an important and previously unsuspected role in human cell division, according to a new study by scientists at The Wistar Institute. When the BRCA2 protein is inactivated, their experiments showed, cells are dramatically delayed in their progress through mitosis, the cell-division stage of the cell cycle. The f...

BRCA1 cancer gene plays pivotal role in DNA control complex

.During the last decade, researchers have been able to confidently link mutations in the BRCA1 gene to familial breast and ovarian cancers. The actual mechanism involved, however, has eluded them. What role does BRCA1 play in health, and how do specific flaws in the gene lead to cancer?. .In the July 21 issue of Cell, scientists at The Wistar Institute report that the BRCA1 protein lies at the c...

BRCA1 mutations in Polish breast-ovarian cancer families

. Many different mutations have been identified in the breast and ovarian cancer susceptibility gene, BRCA1. Since BRCA1 is a large gene and mutation screening cannot be targeted to a small number of potential mutation sites, the screening process is time consuming and expensive. . Gorski and his colleagues from the Pomeranian Academy of Medicine in Poland, have examined Polish families that a...

Penn researchers find ovary removal reduces risk of breast cancer in women withBRCA1 mutation

.(Philadelphia, PA) -- Women carrying a mutation in the BRCA1 gene can cut their.breast cancer by 70 percent by undergoing a bilateral prophylactic oophorectomy.(BPO), or removal of their two ovaries, say researchers at the University of.Pennsylvania Cancer Center. These findings are published in the September 1,.1999 issue of the Journal of the National Cancer Institute. . "This is the first...

Multi-Center Study Provides Guidelines For Genetic Testing In Women With Breast Cancer: BRCA Abnormalities Multiply Risk Of Ovarian Cancer

.A study published in the July issue of the Journal of Clinical Oncology provides.new guidelines to help physicians recognize which women should be assessed for.hereditary breast and ovarian cancer. Scientists at 12 of the country's leading.hereditary cancer centers collaborated with Myriad Genetic Laboratories to.examine 238 women diagnosed with breast cancer before age 50 or with ovarian.cance...

New Study Of BRCA1 Shows No Need For Widespread Screening Of American Women

. American women who do not have a strong family history of breast cancer.should not feel the need to be tested for BRCA1, the gene whose mutations are.associated with a predisposition to breast cancer.. Cancer researchers, led by Dr. Beth Newman* of the Lineberger.Comprehensive Cancer Center at the University of North Carolina at Chapel Hill.and Dr. Mary-Claire King* of the Univ...
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