In harshest environments, some proteins protected by 'alternate' folding mode
...uding lysosomes in human cells, where proteins are broken down for recycling. The UCSF research is published in the January 17 issue of the journal Nature. Most proteins -- made of linear chains of amino acids fold spontaneously into their working configuration, a shape that represents their mos...Access to healthy foods limited in poor neighborhoods
...urnal of Preventive Medicine, also shows that when broken down by race, not just wealth, there are four times as many supermarkets in predominantly white neighborhoods as in black neighborhoods. Black households are less likely to have a car or truck available, the study showed. The lack of private transpor...New portable device senses chemical weapons
...ght sources (lamps), the light from which could be broken into the various colors of the spectrum. Each mate...rocess was lengthy and laborious, each color being broken down and applied one at a time, it was replaced by Fourier Transform spectroscopy, a multiplex techn...Scientists using gene chips identify a unique form of leukemia
...s, portions of their 4th and 11th chromosomes have broken off and swapped places. As a result a gene known as MLL is altered, leading to the runaway growth that typifies cancer. A similar finding in another rare cancer, Chronic Myelogenous Leukemia, or CML, led to the development of a drug to block the over...... However, this destructive cycle can apparently be broken by blocking DDR2 function, collagen deposition, or MMP2 activity. Interestingly, providing large amounts of normal basement membrane as a substratum also reverts the activated phenotype of stellate cells and can suppress their expression of DDR2....Scientists chart iron cycle in ocean
...the findings on how the complex iron molecules are broken down by sunlight could also contribute to research on alternate drug delivery systems, possibly providing a nanoscale vessel that reacts upon exposure to light....University of Ulster spearheads giant leap forward in medicine
...age the frogs to secrete their venom which is then broken down into its component parts in the hi-tech laboratory. After screening the venom the researchers are then able to explore its medical potential. Peptides obtained from the Giant Mexican Leaf Frog have been found to reduce blood pressure by 50% when...Structure shows repair protein cradling broken DNA
...rforms the crucial task of detecting and repairing broken strands of DNA. The images show that the protein i...end joining (NHEJ), which stitches double-stranded broken ends back together even though the ends of each DNA strand may not be complementary. Kus role in mai...Study reveals molecular key to tumor suppressor activity
...eus to the cytoplasm, where it would get degraded, broken down. Moreover, they discovered how this transport is blocked when DNA damage occurs. "P53 is not needed in normal cell growth under conditions of no DNA damage. Otherwise, the cell won't be able to grow," Xiong said. "So the cell handles that by exp......n project," says Stefanov. "When the soil has been broken up, the fine material, where a lot of these pesticides and heavy metals might be, are free to be picked up by the wind." Frequent watering of the ground surface during construction helps to minimize transport of this dust. Agriculture and industry m...New U. of Colorado research may reduce renewable fuel costs
...tially, repeating chains of glucose -- needs to be broken down into smaller segments in order to produce ethanol. A class of enzymes known as cellulase, which are found in some species of fungi and bacteria, break chemical bonds between glucose sub-units that make up cellulose. Fermentation of the glucos...Brain gene implicated in autism
...ople with autism. Also, WNT2 is located next to a broken chromosome in an individual with autism, heightening suspicion of its involvement in the disorder. Among 135 individuals with autism screened, the researchers identified two families in which mutated variants of WNT2 were found in just one parent a...'Silent' DNA speaks up for the first time
... raising the temperature of cells, biologists have broken through what was considered an impermeable barrier that kept half the genes in some cells "silent." The surprising results, in which these heated genes reached 500 times their normal rate of expression, could lead to better understanding of cellular...... that destroy proteins, so it is less likely to be broken down before it meets its target. Smaller molecules like Compstatin are also more readily adaptable to use as an oral medication. Lambris and his colleagues have already demonstrated Compstatins abilities in the laboratory, and the NIGMS grant makes...A paradox helps explain how aspirin works
...ffectiveness because, after 15 minutes, aspirin is broken down in the body and becomes salicylic acid, a completely ineffective inhibitor of COX. By 1994, aspirin was found to actually repress the activation of NF-ΚB, a molecular activator of cytokines, chemicals that trigger inflammation. Casolar...Disconnect between skin cells implicated in common skin cancer
... When their bonds with their neighboring cells are broken through wounding, for example, they begin to proliferate (grow and divide) to repair the wound. During this process, the cells must keep the number of intercellular contacts to a minimum so that they are free to move in to the wound site. "Alpha-cate...Researchers discover weight-loss compound that doesnt affect food intake
... with our constant, abundant food supply. Food is broken down in our intestines to form free fatty acids, which are then absorbed by the body and circulate in the blood. When we dont expend energy the free fatty acids can be stored for the long term as fat or converted to sugar and stored for short-term u...Biologists uncover Darwins missing evidence for divergence of species in a warblers song
... which is treeless and uninhabitable. This ring is broken by a species boundary at only one place, in central Siberia, where two forms of the songbird coexist without interbreeding. "This creates a paradox in which the two co-existing forms can be considered as two species and as a single species at the sa......ot the case." Walker hopes the CT scan will reveal broken pottery, glass and other material that will help researchers piece together information about life on the Denbigh. Arnold said the CT images will also allow for injecting plastic into vacant spaces to create casts of any items that have disintegrate...The embargo on this release has been broken inadvertantly by a news organization, and the news release is available for immediate use. A lifestyle of smoking and heavy drinking may predispose individuals to make poor food choices and increase their health risks, according to the results of a...