New compound 'highly efficacious' at reducing human tumour growth
...olved in the development and perpetuation of human cancer cells", said Dr. Siemeister. The compound has already entered phase I clinical trials to determine tolerability and pharmacokinetics in humans and to establish its efficacy in humans"....Protein controls acid in cells by direct detection of volume changes, study finds
...es of nearly all cells and is especially active in cancer cells, is regulated by the stretch and pull of the...s studies have suggested that NHE1 plays a role in cancer cells that are trying to spread, or metastasize, to different parts of the body. As cancer cells mov...JCI table of contents, 1 July 2004
...eal Thyself Anti-cancer immune cells are found in cancer patients, but these cells fail to reject tumors; a...ivation and tumor infiltration of these cells from cancer patients themselves. The authors show that patients' bone marrow is enriched for subsets of anti-tum...Cancer gene MYC emerging as key research target
...ILADELPHIA--First discovered twenty years ago, the cancer gene MYC is the most overexpressed oncogene in hum...tations are associated with a wide range of common cancer types, including breast, colon, ovarian and prostate cancers, and melanoma. Recent studies have dete...How DNA repair machinery is a 'Two-Way Street'
...st repair DNA biosynthetic errors," he said. "Many cancer chemotherapeutic drugs work by damaging DNA, which selectively kills cancer cells because they are proliferating more than resting cells. The mismatch repair machinery senses c...ALL survivors bear genetic damage from life-saving chemotherapy
... are powerful, and while they are designed to keep cancer cells from proliferating and to induce cancer cell death, normal cells can also be affected. "The therapies used to assist these children...Anti-cancer immune cells are found in cancer patients, but these cells fail to reject tumors; a...ivation and tumor infiltration of these cells from cancer patients themselves. The authors show that patients' bone marrow is enriched for subsets of anti-tum......s, of vascular cells to make new blood vessels, of cancer cells to metastasize, and of neurons to develop and make proper connections in the brain. Two years ago Bokoch and his Scripps Research colleagues discovered that Rac is one of the master regulators of cell motilitythe molecules driving the process...Chemical Society announces EPA awards for environmentally friendly technology
... company developed a better route to paclitaxel, a cancer drug used to treat ovarian and breast cancer. Paclitaxel was first isolated from the bark of the Pacific yew tree. Harvesting the bark meant sacrificing the tree, which provides habitat for the endangered spotted owl. Bristol-Myers Squibb designed a ...Innovative efforts target epigenetics, molecular imaging
... gain or loss of such epigenetic marks can lead to cancer and other diseases by upsetting the cell's normal growth cycle. There is also evidence in mice that some imprinted genes may play a role in behavior. The interdisciplinary team led by Dr. Feinberg, who has pioneered the study of epigenetics in cancer...Clemson researcher places hope on pushy photons
...cells around may reduce heart problems and detect cancer at the cellular level. "Light exerts a force," sai...and bounces differently. Compared to normal cells, cancer cells are smaller, more dense and wrinkled, like a raisin. Gao proposes that cancer cells will rea...Early predictor of breast cancer aggressiveness
...rognosis. "Tumors from patients who died of breast cancer had significantly lower levels of ALCAM transcript...the formation of secondary tumors, which makes the cancer harder to treat....Scientist honored for studies of genetic influence on chemotherapy, tumor development
... Lowe, Ph.D., professor and deputy director at the cancer center of Cold Spring Harbor Laboratory in Cold Sp...etic factors that influence the aging and death of cancer cells. The professorship was established in 2000 in honor of NFCR founders Tamara and Franklin...NIH awards grant for cancer research to the University of Wisconsin
...to the University of Wisconsin to help construct a cancer research facility, which will enable basic researc...Wisconsin for research on prostate cancer. "Breast cancer is the second leading cause of death from cancer in American women," Secretary Thompson said. "In 20...New insight into cancer metastasis
...inate and develop, but relatively little about how cancer manages to metastasize and invade distant tissues ... early embryo development. "As a result, cancer cells acquire in one fell swoop many of the abilities they need to execute the complex stages of met...Mutant mice lead to memory insights
...ndings suggest that drugs already being tested for cancer and Huntington's disease might be useful in restor...ame inhibitors that are currently being tested in cancer and Huntington's disease as therapeutic compounds for RTS," wrote the researchers. In the other pape...Tulane opens doors to discovery
... discuss his research into the interaction between cancer and hormones on Thursday, September 30. On the following afternoon, 1998 Nobel Prize winner Ignarro will discuss his research into nitric oxide as a signaling molecule in the cardiovascular system. The full, three-day "Doors to Discovery" program ...New York City study shows newborns more susceptible to pollution than their mothers
...n an association between DNA adducts and increased cancer risk. Despite the estimated 10-fold lower dose of ...d secondhand smoke, has important implications for cancer risk and developmental problems. And it underscores the importance of reducing levels of air polluti...Jefferson researchers develop microchip to track genetic signature of cancer and normal tissue
...n a better understanding of the roles of miRNAs in cancer and provide targets for future drug development. T...gene regulation in a number of cells in normal and cancer tissue," he says. "It opens new avenues for treatment because these miRNA genes are so small, they c...European Commission approves Herceptin + Taxotere as 1st-line therapy in HER2-positive breast cancer
...st-line therapy in HER2-positive metastatic breast cancer patients who have not yet received chemotherapy for their disease. HER2-positive breast cancer patients suffer from a particularly aggressive form of breast cancer which traditionally has a poor ...